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| 1 | Changes in the patterns of inorganic nitrogen and TN/TP ratio and the associated mechanism of biological regulation in the shallow lakes of the middle and lower reaches of the Yangtze River显示文摘The changes of NH3-N, NO3-N, NO2-N and TN/TP were studied during growth and non-growth season in 33 subtropical shallow lakes in the middle and lower reaches of the Yangtze River. There were significant positive correlations among all nutrient concentrations, and the correlations were better in growth season than in non-growth season. When TP>0.1 mgL-1, NH3-N increased sharply in non-growth season with increasing TP, and NO3-N increased in growth season but decreased in non-growth season with TP. These might be attributed to lower dissolved oxygen and low temperature in non-growth season of the hypereutrophic lakes, since nitrification is more sensitive to dissolved oxygen and temperature than antinitrification. When 0.1 mgL-1>TP>0.035 mgL-1, TN and all kinds of inorganic nitrogen were lower in growth season than in non-growth season, and phytoplankton might be the vital regulating factor. When TP<0.035 mgL-1, inorganic nitrogen concentrations were relatively low and NH3-N, NO2-N had significant correlations with phytoplankton, indicating that NH3-N and NO2-N might be limiting factors to phytoplankton. In addition, TN/TP went down with decline in TP concentration, and TN and inorganic nitrogen concentrations were obviously lower in growth season than in non-growth season, suggesting that decreasing nitrogen (especially NH3-N and NO3-N) was an important reason for the decreasing TN/TP in growth season. The ranges of TN/TP were closely related to trophic level in both growth and non-growth seasons, and it is apparent that in the eutrophic and hypertrophic state the TN/TP ratio was obviously lower in growth season than in non-growth season. The changes of the TN/TP ratio were closely correlated with trophic levels, and both declines of TN in the water column and TP release from the sediment were important factors for the decline of the TN/TP ratio in growth season. | WU Shikai XIE Ping WANG Songbo ZHOU Qiong | 2006 | Science China Earth Sciences2006，49，z1： | 14 |
| 2 | Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner显示文摘Angiogenesis,a process by which the preexisting blood vasculature gives rise to new capillary vessels,is associated with a variety of physiologic and pathologic conditions.However,the molecular mechanism underlying this important process remains poorly understood.Here we show that histone deacetylase 6(HDAC6),a microtubule-associated enzyme critical for cell motility,contributes to angiogenesis by regulating the polarization and migration of vascular endothelial cells.Inhibition of HDAC6 activity impairs the formation of new blood vessels in chick embryos and in angioreactors implanted in mice.The requirement for HDAC6 in angiogenesis is corroborated in vitro by analysis of endothelial tube formation and capillary sprouting.Our data further show that HDAC6 stimulates membrane ruffling at the leading edge to promote cell polarization.In addition,microtubule end binding protein 1(EB1)is important for HDAC6 to exert its activity towards the migration of endothelial cells and generation of capillary-like structures.These results thus identify HDAC6 as a novel player in the angiogenic process and offer novel insights into the molecular mechanism governing endothelial cell migration and angiogenesis. | Dengwen Li Songbo Xie Yuan Ren Lihong Huo Jinmin Gao Dandan Cui Min Liu Jun Zhou | 2011 | Protein & Cell2011，2，2： | 13 |
| 3 | High-quality Arabidopsis thaliana Genome Assembly with Nanopore and HiFi Long Reads显示文摘Arabidopsis thaliana is an important and long-established model species for plant molecular biology,genetics,epigenetics,and genomics.However,the latest version of reference genome still contains a significant number of missing segments.Here,we reported a high-quality and almost complete Col-0 genome assembly with two gaps(named Col-XJTU)by combining the Oxford Nanopore Technologies ultra-long reads,Pacific Biosciences high-fidelity long reads,and Hi-C data.The total genome assembly size is 133,725,193 bp,introducing 14.6 Mb of novel sequences compared to the TAIR10.1 reference genome.All five chromosomes of the Col-XJTU assembly are highly accurate with consensus quality(QV)scores>60(ranging from 62 to 68),which are higher than those of the TAIR10.1 reference(ranging from 45 to 52).We completely resolved chromosome(Chr)3 and Chr5 in a telomere-to-telomere manner.Chr4 was completely resolved except the nucleolar organizing regions,which comprise long repetitive DNA fragments.The Chrl centromere(CEN1),reportedly around 9 Mb in length,is particularly challenging to assemble due to the presence of tens of thousands of CEN180 satellite repeats.Using the cutting-edge sequencing data and novel computational approaches,we assembled a 3.8-Mb-long CEN1 and a 3.5-Mb-long CEN2.We also investigated the structure and epigenetics of centromeres.Four clusters of CEN180 monomers were detected,and the centromere-specific histone H3-like protein(CENH3)exhibited a strong preference for CEN180 Cluster 3.Moreover,we observed hypomethylation patterns in CENH3-enriched regions.We believe that this high-quality genome assembly,Col-XJTU,would serve as a valuable reference to better understand the global pattern of centromeric polymorphisms,as well as the genetic and epigenetic features in plants. | Bo Wang Xiaofei Yang Yanyan Jia Yu Xu Peng Jia Ningxin Dang Songbo Wang Tun Xu Xixi Zhao Shenghan Gao Quanbin Dong Kai Ye | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 6 |
| 4 | Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells显示文摘胰腺的癌症是有在所有主要人的恶意之中的最糟的预后的破坏疾病。很快转移的倾向显著地作出贡献到胰腺的癌症的高度好攻击的特征。位于这下面的分子的机制留下逃犯,并且涉及胰腺的癌症房间活动性的控制的蛋白质充分没被描绘。在这研究,我们发现那 histone deacetylase 6 (HDAC6 ) ,班 II HDAC 家庭的一个成员,高度在人的胰腺的癌症纸巾在蛋白质和 mRNA 层次被表示。HDAC6 显然不影响胰腺的癌症房间增长或房间周期前进。相反,它显著地支持胰腺的癌症房间的活动性。进一步的研究表明 HDAC6 与细胞质的连接器蛋白质 170 交往(CLIP-170 ) 并且这二蛋白质一起工作刺激胰腺的癌症房间的迁居。这些调查结果提供机械学的卓见进胰腺的癌症的前进并且为这恶意的管理作为一个潜在的目标建议 HDAC6。 | Dengwen Li Xiaodong Sun Linlin Zhang Bing Yan Songbo Xie Ruming Liu Min Liu Jun Zhou | 2014 | Protein & Cell2014，5，3： | 5 |
| 5 | Medicinals with properties of warming Yang and tonifying Qi in terms of Traditional Chinese Medicine: their effects on left ventricular ejection fraction and aldosterone in rats with induced failure heart显示文摘OBJECTIVE: To investigate on Left ventricular ejection fraction value and aldosterone of two medicinals of Traditional Chinese Medicine(TCM) with the properties of warming Yang and tonifying Qi in terms of TCM theory.METHODS: An animal model of coronary ligation of heart failure after myocardial infarction was employed to study the influence of these two kinds of drugs on three batches of rats. On the basis of the average score of left ventricle ejection fraction during the investigation, there were some different groups, including Wen Yang(the warming Yang)group, Yi Qi(tonifying Qi) group, Wen Yang and Yi Qi group, captopril group, digoxin group. In additional, an artificial operation group was set for compari-son. The systemic intervention using these medicinal and drugs was taken effects on the 2nd day after the operation of myocardial infraction(MI) with once a day. At week one, two, and four after the MI treatment, evaluated were EF values, and ferritin,angiotensin-II and aldosterone in the rats' plasma.RESULTS: At week one and week two, the medicinal of Wen Yang, Yi Qi, Wen Yang pluse Yi Qi, and digoxin could improve left ventricular ejection fraction in rats with heart failure; Compared to the model group, captopril Left ventricular EF value increased, but there was not significant. At week four,heart failure and left ventricular EF values was improved in the intervention group and the other four captopril drug intervention. At week one in the rats with drug intervention, the medicinals of Yi Qi, Wen Yang plus Yi Qi, and captopril could inhibit activation in vivo hormone aldosterone in heart failure rats; aldosterone in Wen Yang group and digoxin group were not different from that in the model group at week two and four.CONCLUSION: Chinese medicinals with properties of Wen Yang, Yi Qi have significant effect on improving left ventricular EF in rats with heart failure; compared to Yi Qi medicinals, Wen Yang medicinals that inhibit the effectiveness of the time required for the activation of the role of aldosterone. The medicinals of Wen Yang and Yi Qi seems better by inhibiting the activation of the hormone aldosterone after failing to inhibit ventricular remodeling to improve heart failure. | Han Lihua Wang Zhentao Chai Songbo Xing Guohui Wang Hongxing Yuan Bin Li Zhiwei Su Shihao | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 4 |
| 6 | Hydro-pyrolysis of lignocellulosic biomass over alumina supported Platinum, Mo2C and WC catalysts显示文摘 | Songbo He Jeffrey Boom Rolf van der Gaast K. Seshan | 2018 | Frontiers of Chemical Science and Engineering2018，12，1： | 4 |
| 7 | Effects of “Bioactive” amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks显示文摘Feed intake control is vital to ensuring optimal nutrition and achieving full potential for growth and development in poultry. The aim of the present study was to investigate the effects of L-leucine, L-glutamate, L-tryptophan and L-arginine on feed intake and the mRNA expression levels of hypothalamic Neuropeptide involved in feed intake regulation in broiler chicks. Leucine, glutamate, tryptophan or arginine was intra-cerebroventricularly (ICV) administrated to 4d-old broiler chicks respectively and the feed intake were recorded at various time points. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of Neuropeptide Y (NPY), agouti related protein (AgRP), pro-opiomelanocortin (POMC), melanocortin receptor 4 (MC4R) and corticotrophin releasing factor (CRF). Our results showed that ICV administration of L-leucine (0.15 or 1.5 μmol) significantly (P<0.05) increased feed intake up to 2 h post-administration period and elevated both hypothalamic NPY and AgRP mRNA expression levels. In contrast, ICV administration of L-glutamate (1.6μmol) significantly (P<0.05) decreased feed intake 0.25, 0.5 and 2 h post-injection, and increased hypothalamic CRF and MC4R mRNA expression levels. Meanwhile, both L-tryptophan (10 or 100μg) and L-arginine (20 or 200μg) had no significant effect on feed intake. These findings suggested that L-leucine and L-glutamate could act within the hypothalamus to influence food intake, and that both orexigenic and anorexigenic Neuropeptide genes might contribute directly to these effects. | Songbo Wang Paul Khondowe Shengfeng Chen Jianjian Yu Gang Shu Xiaotong Zhu Lina Wang Ping Gao Qianyun Xi Yongliang Zhang Qingyan Jiang | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 3 |
| 8 | Effect of diacylglycerol acyltransferase 2overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation显示文摘Background:Fatty acid(FA) composition is the most important parameter affecting the flavor and nutritional value of the meat.The final and the only committed step in the biosynthesis of triglycerides is catalyzed by diacylglycerol acyltransferase 2(DGAT2).The role of DGAT2 in lipid accumulation has been demonstrated in adipocytes,However,little is known about the effect of DGAT2 on the FA composition of these cells.Methods:To investigate the role of DGAT2 in regulating lipid accumulation,FA composition and the expression of adipogenic genes,we cloned the open reading frame of the porcine DGAT2 gene and established 3T3-L1 cells that overexpressed DGAT2.Cells were then cultured in differentiation medium(DM) without FA,with a mixture of FAs(FA-DM),or containing a ^(13)C stable isotope-labeled FA mixture(IFA-DM).The FA composition of adipocytes was analyzed by gas chromatography-mass spectrometry and gas chromatography-isotope ratio mass spectrometry.Quantitative PCR and western blotting were employed to detect expression of adipogenic genes in 3T3-L1 adipocytes cultured with FA-DM for 12 d.Results:The triacylglyceride(TAG) content was significantly higher in 3T3-L1 adipocytes overexpressing DGAT2 than in control cells.When cultured in DM or FA-DM for 12 d,cells overexpressing DGAT2 showed a higher proportion of unsaturated FAs(C16:1 and C18:1).However,when cells overexpressing DGAT2 were cultured with FA-DM for30 min,the FA composition was almost identical to that of controls.Further,the proportion of stable isotope-labeled FAs were similar in 3T3-L1 adipocytes overexpressing DGAT2 and control cells cultured in IFA-DM for 12 d.These results collectively indicate that the higher proportion of mono-unsaturated FAs,C16:1 and C18:1,may originate from de novo FA synthesis but not from the uptake of specific FAs from the medium.This hypothesis is further supported by evidence that both mRNA and protein expression of genes involved in FA synthesis(ACACA,FASN,SCD1,and A-FABP)were significantly higher in cells overexpressing DGAT2 than in control cells.Conclusions:In conclusion,our study revealed that TAG accumulation,the proportion of MUFAs,and the expression of adipogenic genes were higher in 3T3-L1 cells overexpressing DGAT2 than in control cells. | Zhiqi Zhang Gang Shu Xiaotong Zhu Junming Guo Han Cai Songbo Wang Lina Wang Ping Gao Qianyun Xi Yongliang Zhang Li Yuan Qingyan Jiang | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 3 |
| 9 | A review of methods for mitigating ionospheric artifacts in differential SAR interferometry显示文摘Interferometric synthetic aperture radar(InSAR)has been widely used to measure ground displacements related to geophysical and anthropic activities over the past three decades.Satellite SAR systems use microwave signals that interact with the ionosphere when they travel through it during the imaging processes.In this context,ionospheric variations can significantly contaminate SAR imagery,which in turn affects spaceborne InSAR measurements.This bias also leads to a decrease in the coherence and accuracy of InSAR measurements,especially for the low-frequency SAR systems.In this paper,we give an overview of the latest methods for mitigating the ionospheric contributions in InSAR,including Faraday rotation method,azimuth shift method,and range split-spectrum method,and only focus on the single pair of InSAR interferograms.The current challenges and future perspectives are outlined at the end of this paper. | Bochen Zhang Wu Zhu Xiaoli Ding Chisheng Wang Songbo Wu Qin Zhang | 2022 | Geodesy and Geodynamics2022，13，2： | 2 |
| 10 | The luminescence properties of Sr_3Gd(BO_3)_3:Tb^(3+) phosphors under vacuum ultraviolet excitation显示文摘Tb3+-activated Sr3Gd(BO3)3 green phosphors were prepared by conventional solid-state reaction. The vacuum ultraviolet (VUV) excitation, photoluminescence (PL) and decay properties of the phosphors in the visible range were investigated. The excitation spectrum showed a strong broad band from 160 to 200 nm with a maximum at 183 nm which was adjacent to the VUV excitation light source of 172 nm. Under excitation at 172 nm, the optimum co-doping concentration of Tb3+ was 10 mol%, and the emission intensity of Sr3Gd0.9(BO3)3:0.1Tb3+ was comparable to that of commercial Zn2SiO4:Mn2+. The strongest emission peak of Sr3Gd0.9(BO3)3:0.1Tb3+ was at 543 nm with chromaticity coordinates of (0.2626, 0.4922) and a lifetime of 2.32 ms. The optical properties of the green phosphor Sr3Gd(BO3)3:Tb3+ make it suitable for use in Hg-free fluorescent lamps and plasma display panels. | ZHAO WenYu GAO SongWei AN ShengLi FAN Bin LI SongBo | 2012 | Chinese Science Bulletin2012，57，34： | 2 |
| 11 | An empirical study of sentiment analysis for Chinese documents 显示文摘 | Tan Songbo Zhang Jin | 2008 | Expert Systems with Applications2008，34，4： | 1 |
| 12 | An effective refinement strategy for KNN text classifier显示文摘 | Songbo T | 2006 | Expert Systems with Applications2006，30，： | 1 |
| 13 | The ozone mass transfer characteristics and ozonation of pentachlorophenol in a novel microchannel reactor显示文摘 | Jian Ren Songbo He Chunbo Ye Guangwen Chen Chenglin Sun | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 14 | Dehydrogenation of long chain paraffins over supported Pt-Sn-K/AI2 03 catalysts: a study of the alumina support effect显示文摘 | He Songbo Sun Chenglin Bai Ziwu | 2009 | Applied Catalysis A: General2009，365，： | 1 |
| 15 | Analysis of short fruiting branch gene and Marker-assisted selection with SNP linked to its trait in upland cotton显示文摘Background: With the rapid development of genomics, many functional genes have been targeted. Molecular marker assisted selection can accelerate the breeding process by linking selection to functional genes.Methods: In a study of upland cotton(Gossypium hirsutum L.), the F_2 segregated population was constructed by crossing X1570(short branches) with Ekangmian-13(long branches) to identify the short fruiting branch gene and marker-assisted selection with SNP(Single Nucleotide Polymorphisms, SNP) linked to its trait.Result: The result demonstrated that linked SSR marker BNL3232 was screened by BSA(Bulked segregant analysis,BSA) method; one SNP locus was found, which was totally separated from the fruiting branches trait in upland cotton.Conclusion: It was verified that this SNP marker could be used for molecular assisted selection of cotton architecture. | ZHANG Youchang FENG Changhui BIE Shu WANG Xiaogang ZHANG Jiaohai XIA Songbo QIN Hongde | 2018 | Journal of Cotton Research2018，1，1： | 1 |
| 16 | Versatile sensing devices for self-driven designated therapy based on robust breathable composite films显示文摘Flexible wearable electronics were developed for applications such as electronic skins,human-machine interactions,healthcare monitoring,and anti-infection therapy.But conventional materials showed impermeability,single sensing ability,and no designated therapy,which hindered their applications.Thus it was still a great challenge to develop electronic devices with multifunctional sensing properties and self-driven anti-infection therapy.Herein,flexible and breathable on-skin electronic devices for multifunctional fabric based sensing and self-driven designated anti-infection therapy were prepared successfully with cellulose nanocrystals/iron(Ⅲ)ion/polyvinyl alcohol(CNC/Fe^(3+)/PVA)composite.The resultant composite films possessed robust mechanical performances,outstanding conductivity,and distinguished breathability(3.03 kg/(m^(2)·d)),which benefited from the multiple interactions of weak hydrogen bonds and Fe^(3+) chelation and synergistic effects among CNC,polyaniline(PANI),and PVA.Surprisingly,the film could be assembled as a multifunctional sensor to actively monitor real-time physical and infection related signals such as temperature,moisture,pH,NH3,and human movements even at sweat states.More importantly,this multifunctional device could act as a self-driven therapist to eliminate bacterial by the release of Fe^(3+),which was driven by the damage of metal coordination Fe-O bonds due to the high temperature caused by infection at wound sites.Thus,the composite films had potential versatile applications in electronic skins,smart wound dressings,human-machine interactions,and self-driven anti-infection therapy. | Zhaofeng Ouyang Songbo Cui Houyong Yu Dewen Xu Chuang Wang Dongping Tang Kam Chiu Tam | 2022 | Nano Research2022，15，2： | 1 |
| 17 | Neighbor-weighted K-nearest neighbor for unbalanced text corpus显示文摘 | | 2005 | Expert Systems with Application2005，28，4： | 1 |
| 18 | An effective refinement strategy for KNN text classifier 显示文摘 | SONGBO T | 2006 | Expert Systems with Applications2006，30，： | 1 |
| 19 | Dehydrogenation of long chain paraffins over supported Pt-Sn-K/AUOa catalysts; A study of the alumina support effect显示文摘 | He Songbo? Sun Chenglin Bai Ziwu | 2009 | Appl Catal A2009，356，1： | 1 |
| 20 | Characterization of coke deposited on spent catalysts for long-chain-paraffin dehydrogenation显示文摘 | He Songbo Sun Chenglin Xu Yang | 2010 | Chemical Engineering Journal2010，163，： | 1 |
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