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| 1 | Current status,trends,and predictions in the burden of gallbladder and biliary tract cancer in China from 1990 to 2019显示文摘Background:Gallbladder and biliary tract cancer(GBTC)has greatly damaged the health of patients and is accompanied by a dismal prognosis.The worldwide distribution of GBTC shows extensive variance and the updated data in China is lacking.This study was to determine the current status,trends,and predictions in the burden of GBTC over the past 30 years in China.Methods:This was a descriptive,epidemiological,secondary analysis of the Global Burden of Disease,Injuries,and Risk Factor Study 2019 data.Data including incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of GBTC in China by year,age,and sex were assessed.Joinpoint regression analysis was conducted to evaluate trends of disease burden due to GBTC from 1990 to 2019.Nordpred age-period-cohort analysis was applied for the projection of mortality and incidence due to GBTC from 2019 to 2044.Results:Nationally,there were 38,634(95%uncertainty interval[UI]:27,350-46,512)new cases and 47,278(95%UI:32,889-57,229)patients due to GBTC,causing 34,462(95%UI:25,220-41,231)deaths,and 763,584(95%UI:566,755-920,493)DALYs in 2019.Both cases and rates of burden owing to GBTC were heavier among males and at old age.From 1990 to 2019,the age-standardized rates of incidence,prevalence,mortality,and DALYs of GBTC generally increased from 1990 to 2019,with average annual percentage change at 0.8%(95%confidential interval[CI]:0.6-1.0%),1.3%(95%CI:1.1-1.5%),0.4%(95%CI:0.2-0.6%),and 0.2%(95%CI:0.1-0.4%),respectively.Even though the age-standardized incidence rate and agestandardized mortality rate in both sexes were predicted to decline gradually from 2019 to 2044,the number of new cases and deaths were expected to grow steadily.Conclusions:GBTC is becoming a major health burden in China,particularly among males and older individuals.Given the aging population and increasing burden,effective strategies and measurements are urged to prevent or reduce the number of new cases and deaths of GBTC. | Shimin Chen Ke Han Yang Song Shaohua Liu Xuehang Li Shengshu Wang Haowei Li Rongrong Li Jianhua Wang Yao He Miao Liu | 2022 | Chinese Medical Journal2022，，14： | 2 |
| 2 | A preliminary study on the preparation of four pacific ocean polymetallic nodule and sediment reference materials: GSPN-2, GSPN-3, GSMS-2 and GSMS-3 显示文摘 | Wang Yimin Luo Daihong Gao Yushu Song Haowei Li Jiaxi Chen Weiyue Teng Yunye Zhou Shiguang | 1998 | Geostandards Newsletter1998，22，2： | 1 |
| 3 | Ocean Manganese Nodule and Sediment Reference Materials 显示文摘 | Wang Yimin Song Haowei Wang Xiaohong | 1998 | Marine Georesources & Geotechnology1998，16，4： | 1 |
| 4 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 5 | A preliminary study on the preparation of four Pacific ocean polymetallic nodule and sediment reference materials: GSPN-2, GSPN-3, GSMS-2 and GSMS-3 显示文摘 | Wang Yimin Luo Daihong Gao Yushu Song Haowei Li Jiaxi Chen Weiyue Teng Yunye Zhou Shiguang | 1998 | C eostandards Newsletter1998，22，2： | 1 |
| 6 | LM-11 Launches 5 Satellites into Orbit显示文摘At 14:42 Beijing time on September 19,a LM-1 I solid launch vehicle lifted off from the Jiuquan Satellite Launch Center and launched the Zhuhai I-03 group of 5 satellites into their preset orbits.Zhuhai I-03 group satellites in elude a sec on d-ge neration video micro/nano satellite and 4 second-generation hyper-spectral micro/nano satellites. | SONG Haowei | 2019 | Aerospace China2019，20，3： | 0 |
| 7 | 航天科技集团发布《中国航天科技活动蓝皮书(2021年)》显示文摘A press conference of 2021 Blue Book of China Aerospace Science and Technology was held in Beijing on 9 th February, 2022. According to the Blue Book, CASC will conduct over 50 flights including six manned space flights in 2022 to complete the building of its space station and see the maiden flight of LM-6 A, the country’s first carrier rocket powered by solid and liquid engines. | SONG Haowei | 2021 | Aerospace China2021，22，4： | 0 |
| 8 | Measurement of dynamic membrane mechanosensation using optical tweezers显示文摘Many cellular processes are orchestrated by dynamic changes in the plasma membrane to form membrane projections and endocytic compartments in response to extracellular cue changes.Our previous studies show that post-translational modifications of ACAP4 regulate membrane dynamics and curvature in response to epidermal growth factor and chemokine(C−C motif)ligand 18 stimulation(Zhao et al.,2013;Song et al.,2018). | Xuanling Li Xing Liu Xiaoyu Song Yinmei Li Ming Li Haowei Wang | 2021 | Journal of Molecular Cell Biology2021，13，6： | 0 |
| 9 | Nature:研究发现糖尿病的炎症起因显示文摘炎症是糖尿病患者发生心脏病、中风、肾脏疾病及其他相关并发症的主要原因之一。现在华盛顿大学医学院的研究人员发现了慢性炎症的一个可能的触发因素。 | Xiaochao Wei, Haowei Song, Li Yin, Michael G. Rizzo Clay F. Semenkovich Rohini Sidhu Daniel S. Ory Douglas F. Covey Clay F. Semenkovich | 2017 | 现代生物医学进展2017，17，6： | 0 |
| 10 | 长征三号乙改进五型运载火箭成功发射高分十四号卫星显示文摘A LM-3B launch vehicle was launched from the Xichang Satellite Launch Center at 11:58 Beijing time on December 6,transferring the Gaofen 14 satellite into its preset orbit successfully.This was the first time for LM-3B to transport a spacecraft into a sun-synchronous orbit.The rocket was developed by the China Academy of Launch Vehicle Technology under CASC. | SONG Haowei | 2020 | Aerospace China2020，21，4： | 0 |
| 11 | Numerical Simulation Analysis of the Transformer Fire Extinguishing Process with a High-Pressure Water Mist System under Different Conditions显示文摘To thoroughly study the extinguishing effect of a high-pressure water mist fire extinguishing system when a transformer fire occurs,a 3D experimental model of a transformer is established in this work by employing Fire Dynamics Simulator(FDS)software.More specifically,by setting different parameters,the process of the highpressure water mist fire extinguishing system with the presence of both diverse ambient temperatures and water mist sprinkler laying conditions is simulated.In addition,the fire extinguishing effect of the employed high-pressure water mist system with the implementation of different strategies is systematically analyzed.The extracted results show that a fire source farther away fromthe centerline leads to a lower local temperature distribution.In addition,as the ambient temperature increases,the temperature above the fire source decreases,while the temperature and the concentrationof theupperflue gas layer bothdecrease.Interestingly,after thehigh-pressurewatermist sprinkler begins to operate,both the temperature distribution above the fire source and the concentration of the flue gas decrease,which indicates that the high-pressure water mist system plays the role of cooling and dust removal.By comparing various sprinkler laying methods,it is found that the lower sprinkler height has a better effect on the temperature above the fire source,the temperature of the upper flue gas layer,and the concentration of the flue gas.Moreover,when the sprinkler is spread over thewhole transformer,the cooling effect on both the temperature above the fire source and the temperature of the upper flue gas layer is good,whereas the change in the concentration of the flue gas above the fire source is not obvious compared to the case where the sprinkler is not fully spread. | Haowei Yao Youxin Li Kefeng Lv Dong Wang Jinguang Zhang Zhenyu Zhan Zhenyu Wang Huaitao Song Xiaoge Wei Hengjie Qin | 2023 | Computer Modeling in Engineering & Sciences2023，，7： | 0 |
| 12 | LM-11 Starts China's Commercial Launch Activity in 2019显示文摘At 13:42 Beijing time on January 21,a LM-11 solid carrier rocket soared up from the Jiuquan Satellite Launch Center,carrying Jilin-1 GP-01 and 02 satellites and 2 piggyback satellites into orbit.LM-11 was developed by the China Academy of Launch Vehicle Technology for launching medium-and small-sized spacecraft into SSO and near Earth orbit with a launch capacity of 420 kg to a 700 km SSO. | SONG Haowei | 2019 | Aerospace China2019，20，1： | 0 |
| 13 | 长征二号丁运载火箭成功发射试验六号02卫星显示文摘A LM-2 D launch vehicle launched the Shiyan 6-02 satellite into its preset orbit from the Jiuquan Satellite Launch Center at 07:44 Beijing time on July 5.Developed by the Shanghai Academy of Spaceflight Technology, the LM-2 D launch vehicle is a two-stage conventional liquid propellant rocket. | SONG Haowei | 2020 | Aerospace China2020，21，2： | 0 |
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