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| 1 | Effects of partial portal vein arterialization on the hilar bile duct in a rat model显示文摘BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P<0.01). No apoptotic hilar bile duct epithelial cells were detected in any of the groups. The PBP arteriolar counts of the hilar bile duc wall were similar in groups A and C (P>0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation. | Shao-Hua Guo, Chong-Hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (Guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo SH), General Hospital of PLA, Beijing 100853, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 8 |
| 2 | Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture显示文摘 | Pan W Quarles LD Song LH Yu YH Jiao C Tang HB Jiang CH Deng HW Li YJ Zhou HH Xiao ZS | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 3 | Factors inurning chloride transport in concrete structures exposed to ma- rine environments显示文摘 | SONG H A-WON LEE CH ANG-H ONG KI YONGANN | 2008 | Cement and concrete composites2008，30，2： | 1 |
| 4 | Effect of hypo-,iso- and hypertonic saline irrigation on secretory mucins and morphology of cultured human nasal epithelial cells显示文摘 | Kim CH Hyun Song M Eun Ahn Y | 2005 | Acta Otolaryngol2005，125，12： | 1 |
| 5 | Left ventricular torsion is equal in mice and humans 显示文摘 | Henson RE Song SK Pastorek JS Ackerman JJH Lorenz CH | 2000 | Am J Physiol Heart Circ Physiol2000，278，4： | 1 |
| 6 | Shape-selective isopropylation of naphthalene over mordenite catalysts: Computational analysis using MOPAC 显示文摘 | Ma X Schmitz A D | 1999 | Applied Catalysis A :General1999，182，1： | 1 |
| 7 | Treatment results for gastric cancer:12 year's experience at a single institute in Korea显示文摘 | Par CH Song KY Kim SN | 2008 | Eur J Surg Oncol2008，34，1： | 1 |
| 8 | The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes显示文摘 | Jung SB Yang CS Lee JS Shin AR Jung SS Son JW Har- ding CV Kim HJ Park JK Paik TH Song CH Jo EK | 2006 | Infect Immun2006，74，5： | 1 |
| 9 | A micromachined cavity resonator for millimeter-wave oscillator applications 显示文摘 | SONG I SONG C | 2000 | Sensors and Actuators2000，83，13： | 1 |
| 10 | Extranterine incubation of fetal goats applying the extraeorporeal membrane oxygenation via umbilical artery and vein 显示文摘 | Pak SC Song CH So GY | 2002 | J Korean Med Sei2002，17，5： | 1 |
| 11 | The mirror therapy program enhances upper-limb motor recovery and motor function in acute stroke pa- tients 显示文摘 | Lee MM Cho HY Song CH | 2012 | Am J Phys Med Rehabil2012，91，8： | 1 |
| 12 | Laparoscopy-assisted distal gastrectomy with D2lymph node dissection for gastric cancer:technical and oncologic aspects显示文摘 | Song KY Kim SN Park CH | 2008 | Surg Endosc2008，22，3： | 1 |
| 13 | Effect of thymic stromallymphopoietin on MUC5B expression in human airway epithelialcells显示文摘 | Bae CH Choi YS Song SY | 2014 | Biochem Biophys Res Commun2014，，： | 1 |
| 14 | Probiotics promote endocytic allergen degradation in gut epithelial cells显示文摘 | Song CH Liu ZQ Huang S | | 0，，01： | 1 |
| 15 | Germline stem cells anchored by adherens junctions in the Drosophila ovary niches显示文摘 | Song X Zhu CH Doan C | 2002 | Science2002，296，5574： | 1 |
| 16 | Interfemn-lambda mediates o- ral tolerance and inhibits antigen-specific, T-helper 2 cell-media- ted inflammation in mouse intestine显示文摘 | He SH Chen X Song CH | 2011 | Gastroenterol2011，141，1： | 1 |
| 17 | Decreased ratio of Treg cells to Thl7 correlates with HBV DNA suppression in chronic hepatitis B patients undergoing entecavir treatment 显示文摘 | Zhang JY Song CH Shi F | 2010 | PLoS One2010，5，13： | 1 |
| 18 | Human acyl-CoA: cholesterol acyltransferase 2 gene expression in intestinal caco-2 cells and in hepatocellular carcinoma 显示文摘 | Song BL Wang CH Yao XM | 2006 | Biochem J2006，394，3： | 1 |
| 19 | Prognostic significance of VEGF expression in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy 显示文摘 | Choi CH Song SY Choi JJ | 2008 | BMC Cancer2008，8，： | 1 |
| 20 | Inhibitory effect of epigallocatechin 3 - O- gallate on vascular smooth muscle cellhypertrophy induced by angiotensin Ⅱ 显示文摘 | Zheng Y Song HJ Kim CH | 2004 | J Cardiovasc Pharmacol2004，43，2： | 1 |
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