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| 1 | Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy显示文摘AIM:To analyze pituitary hormone and melatonin circadian rhythms, and to correlate hormonal alterations with clinical performance, hepatic disease severity and diagnostic tests used for the detection of hepatic encephalopathy in cirrhosis. METHODS:Twenty-six patients with cirrhosis were enrolled in the study. Thirteen patients hospitalized for systemic diseases not affecting the liver were included as controls. Liver disease severity was assessed by the Child-Pugh score. All patients underwent detailed neurological assessment, electroencephalogram (EEG), brain magnetic resonance imaging (MRI), assays of pituitary hormone, cortisol and melatonin, and complete blood chemistry evaluation. RESULTS: Pituitary hormone and melatonin circadian patterns were altered in cirrhosis patients without clinical encephalopathy. Circadian hormone alterations were different in cirrhosis patients compared with controls. Although cortisol secretion was not altered in any patient with cirrhosis, the basal cortisol levels were lowand correlated with EEG and brain MRI abnormalities. Melatonin was the only hormone associated with the severity of liver insufficiency. CONCLUSION: Abnormal pituitary hormone and melatonin circadian patterns are present in cirrhosis before the development of hepatic encephalopathy. These abnormalities may be early indicators of impending hepatic encephalopathy. Factors affecting the human biologic clock at the early stages of liver insufficiency require further study. | Dimitrios Velissaris Menelaos Karanikolas Andreas Kalogeropoulos Ekaterini Solomou Panagiotis Polychronopoulos Konstantinos Thomopoulos Chrissoula Labropoulou-Karatza | 2008 | World Journal of Gastroenterology2008，14，26： | 9 |
| 2 | Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV显示文摘 | Juang Y T Wang Y Solomou E E | 2005 | J Clin Invest2005，115，4： | 1 |
| 3 | Aging and lymphocyte subpopulations: whole blood analysis of immune markers in a large population sample of healthy elderly individuals 显示文摘 | Huppert FA Solomou W O' Connor S | 1998 | Exp Gerontol1998，33，6： | 1 |
| 4 | Asympto- matie adult cystic lymphangioma of the spleen: case report and review of the literature 显示文摘 | Solomou EG Patriarheas GV Mpadra FA | 2003 | Magn Reson Imaging2003，21，： | 1 |
| 5 | Asymptomatic adult cystic lymphangioma of the spleen: case report and review of the literature显示文摘 | SOLOMOU EG PATRIARHEAS GV MPADRA FA | 2003 | Magn Reson Imaging2003，21，1： | 1 |
| 6 | Evidence that DKK-l is dysfunctional in ankylosing spondylitis显示文摘 | Daoussis D Liossis SN Solomou EE et a1 | 2010 | Arthritis Rheum2010，62，1： | 1 |
| 7 | Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastic anemia显示文摘 | Solomou E E Rezvani K Mielke S | | 0，，05： | 1 |
| 8 | Rabbit ATG but not horse ATG promotes expansion of functional CD4^+ CD25hish foxp3^+egulutory T cells in vitro显示文摘 | Feng X Kajigaya S Solomou EE | 2008 | Blood2008，111，： | 1 |
| 9 | The 2001 Bethesda system terminology for reporting result of cervical cytology 显示文摘 | Solom on D D avey D Kuman R | 2002 | JAMA2002，287，16： | 1 |
| 10 | Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of inter- leukin-2 promoter activity 显示文摘 | Herndon T M Juang Y T Solomou E E | 2002 | Clin Immunol2002，103，2： | 1 |
| 11 | Evidence that Dkk 1 is dysfunctional in ankylosing spondylitis 显示文摘 | Daoussis D Liossis SNC Solomou EE | 2010 | Arthritis Rheum2010，62，1： | 1 |
| 12 | Deficient CD4 4- CD25 FOXP3-+- T regulatory cells in acquired aplastic anemia显示文摘 | Solomou E E Rezvani K Mielke S | 2007 | Blood2007，110，16： | 1 |
| 13 | T -bet, a Thl transcription factor, is up - regulated in T cells from patients with aplastic anemia显示文摘 | SOLOMOU E E KEYVANFAR K YOUNG N S | 2006 | Blood2006，107，10： | 1 |
| 14 | Deficient CD4^+ CD25^+ FOXP3^+ T regulatory cells in acquired aplastic anemia显示文摘 | Solomou EE Rezvani K Mielke S | 2007 | Blood2007，110，5： | 1 |
| 15 | Deficient CD4+ CD25+FOXP3+T regulatory cells in acquired aplastic anemia 显示文摘 | Solomou EE Rezvani K Mielke S | 2007 | Blood2007，110，5： | 1 |
| 16 | Deficient CD4 ^+ CD25^ + FOXP3^+ T regulatory cells in acquired aplastic anemia 显示文摘 | Solomou E E Rezvani K Mielke S | 2007 | Blood2007，110，5： | 1 |
| 17 | Deficent CD4+ CD25-FOXP3+ T regulatory cells in acquired aplastic anemia显示文摘 | Solomou EE Rezvani K Mielke S | 2007 | Blood2007，110，5： | 1 |
| 18 | Malaria:a haematological disease显示文摘 | AKINOSOGLOU K S SOLOMOU E E GOGOS C A | 2012 | Hematology2012，17，2： | 1 |
| 19 | Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus显示文摘 | Solomou EE Juang YT Gourley MF | 2001 | J Immunol2001，166，6： | 1 |
| 20 | Tv bet , a Th1 transcription factor, is up-regulater in T cells from pa?tients with aplastic anemia显示文摘 | Solomou EE Keyvanfar Young NS et al | 2006 | Blood2006，107，39： | 1 |
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