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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Absorption of insulin in the peritoneal cavity in a diabetic animal model 显示文摘 | Waxman K Soliman MH Nguyen KH | 1993 | Artif Organs1993，17，11： | 1 |
| 3 | External jugular venous pressure as an alternative to conventional central venous pressure in right lobe donor hepatectomies显示文摘 | Abdullah MH Soliman HD Morad WS | | 0，，： | 1 |
| 4 | Absorption of insulin in the peritoneal cavity in a diabetic animal model显示文摘 | Waxman K Soliman MH Nguyen KH | 1993 | Artif Organs1993，17，11： | 1 |
| 5 | Absorption of insulin in the peritoneal cavity in a diabetic animal model显示文摘 | Waxman K Soliman MH Nguyen KH | 1993 | Artif Organs1993，17，11： | 1 |
| 6 | External jugular venous pressure as an alternative to conventional central venous pressure in right lobe donor hepatectomies 显示文摘 | Abdullah MH Soliman Hel D Morad WS | 2011 | Exp Clin Transplant2011，9，6： | 1 |
| 7 | Absorption of insulin in the peritoneal cavity in a diabetic animal model 显示文摘 | Waxman K Soliman MH Nguyen KH | 1993 | Artif Organs1993，17，11： | 1 |
| 8 | Absorption of insulin in the peritoneal cavity in a diabetic animal model显示文摘 | Waxman K Soliman MH Nguyen KH | 1993 | Artif Organs1993，17，： | 1 |
| 9 | Intra-abdominal testis: histological alterations and significance of biopsy显示文摘 | AbouZeid AA Mousa MH Soliman HA | 2011 | J Urol2011，185，1： | 1 |
| 10 | External jugular venous pres- sure as an alternative to conventional central venous pressure in right lobe donor hepatectomies 显示文摘 | Abdullah MH Soliman HD Morad WS | 2011 | Exp Clin Transplant2011，9，6： | 1 |
| 11 | External jugular venous pressure as an alternative to conventional central venous pressure in right lobe donor hepateetomies 显示文摘 | Abdnllah MH Soliman HD Morad WS | 2011 | Experimental and clinical trans- plantation: official journal of the Middle East Society for Organ Transplantation2011，9，6： | 1 |
| 12 | External jugular venous pres- sure as an alternative to conventional central venous pressure in right lobe donor hepatectomies 显示文摘 | Abdullah MH Soliman Hel D Morad WS | 2011 | Exp Clin Transplant2011，9，6： | 1 |
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