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| 1 | Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential显示文摘学习的主要目标是多识别人的新奇来源有势力房间,克服涉及胚胎的干细胞研究和很成年的干细胞的有限可获得性的道德的问题。羊膜的液体房间(声频抗流圈) 习惯性地为出生前的诊断被获得并且能在 vitro 被扩展;他们的起源和性质的不过当前的知识是有限的。声频抗流圈的二十件样品在文化暴露于 adipogenic, osteogenic,神经原并且 myogenic 媒介。区别用免疫细胞化学, RT-PCR 并且西方的弄污被评估。在处理前,声频抗流圈显示出异构的形态学。他们为 MyoD, Myf-5, MRF4, Myogenin 和 Desmin 是否定的但是为由 RT-PCR 的 osteocalcin, PPARgamma2, GAP43, NSE, Nestin, MAP2, GFAP 和贝它导管素 III 积极。房间表示了 Oct-4, Rex-1 和 Runx-1,它描绘无差别的干细胞状态。由免疫细胞化学,他们表示了 neural-glial 蛋白质,间充质、上皮的标记。在文化以后,当占优势的细胞的部件是 fibroblastic 时,声频抗流圈区分了进 adipocytes 和造骨细胞。就算没有 neuronal 形态学是可检测的,早、迟了的 neuronal 抗原仍然是在在神经特定的媒介的 2 星期文化以后的现在。我们的结果提供人的羊膜的液体与为几个系显示出茎和织物特定的基因 / 蛋白质存在的多系潜力包含祖先房间的证据。 | Patrizia Bossolasco Tiziana Montemurro Lidia Cova Stefano Zangrossi Cinzia Calzarossa Simona Buiatiotis Davide Soligo Silvano Bosari Vincenzo Silani Giorgio Lambertenghi Deliliers PaoloRebulla LorenzaLazzari | 2006 | Cell Research2006，16，4： | 20 |
| 2 | Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury显示文摘The purpose of this work was to investigate whether,by intranasal administration,the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury.Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks.We found an increased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats,while daily treatment for 3 weeks in a model of spinal cord injury improved the deficits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors.These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury.They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells. | Luigi Aloe Patrizia Bianchi Alberto De Bellis Marzia Soligo Maria Luisa Rocco | 2014 | Neural Regeneration Research2014，9，10： | 17 |
| 3 | Topical delivery of nerve growth factor for treatment of ocular and brain disorders显示文摘Neurotrophins are a family of proteins that support neuronal proliferation, survival, and differentiation in the central and peripheral nervous systems, and are regulators of neuronal plasticity. Nerve growth factor is one of the best-described neurotrophins and has advanced to clinical trials for treatment of ocular and brain diseases due to its trophic and regenerative properties. Prior trials over the past few decades have produced conflicting results, which have principally been ascribed to adverse effects of systemic nerve growth factor administration, together with poor penetrance of the blood-brain barrier that impairs drug delivery. Contrastingly, recent studies have revealed that topical ocular and intranasal nerve growth factor administration are safe and effective, suggesting that topical nerve growth factor delivery is a potential alternative to both systemic and invasive intracerebral delivery. The therapeutic effects of local nerve growth factor delivery have been extensively investigated for different ophthalmic diseases, including neurotrophic keratitis, glaucoma, retinitis pigmentosa, and dry eye disease. Further, promising pharmacologic effects were reported in an optic glioma model, which indicated that topically administered nerve growth factor diffused far beyond where it was topically applied. These findings support the therapeutic potential of delivering topical nerve growth factor preparations intranasally for acquired and degenerative brain disorders. Preliminary clinical findings in both traumatic and non-traumatic acquired brain injuries are encouraging, especially in pediatric patients, and clinical trials are ongoing. The present review will focus on the therapeutic effects of both ocular and intranasal nerve growth factor delivery for diseases of the brain and eye. | Gemma Eftimiadi Marzia Soligo Luigi Manni Daniela Di Giuda Maria Lucia Calcagni Antonio Chiaretti | 2021 | Neural Regeneration Research2021，16，9： | 11 |
| 4 | The apoptogenic response of human myeloid leukemia cell lings and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI显示文摘 | Soligo D Servida F Delia D | 2001 | Br J Haematol2001，113，1： | 1 |
| 5 | Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor anti- bodies显示文摘 | Quirici N Soligo D Bossolasco P | 2002 | Exp Hematol2002，30，7： | 1 |
| 6 | 显示文摘 | Bertolini F Soligo D | 1999 | Br J Cancer1999，81，： | 1 |
| 7 | Differentiation and expansion of endothelial cells from human bone marrow CD133 ( + ) cells显示文摘 | Quiriei N Soligo D Caneva L | 2001 | Br J Haematol2001，115，： | 1 |
| 8 | Metachronous solitary left a- drenal gland metastasis of right colon cancer treated with laparo- scopic approach显示文摘 | Oldani A Monni M Soligo E | 2014 | Ann Ital Cliir2014，85，3： | 1 |
| 9 | Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies 显示文摘 | Quiriei N Soligo D Bossolasco P | 2002 | Exp Hematol2002，30，7： | 1 |
| 10 | The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI 显示文摘 | Soligo D Servida F Delia D | 2001 | Br J Haematol2001，113，1： | 1 |
| 11 | Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies显示文摘 | Quirici N Soligo D Bossolasco P | 2002 | Exp Hematol2002，30，7： | 1 |
| 12 | A comprehensive assessment of pedestrian comfort including thermal effects 显示文摘 | Soligo M J Irwin P A Williams C J | 1998 | Journal of Wind Engineering and Industrial Aerodynamics1998，7778，1： | 1 |
| 13 | YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response显示文摘 | Azzolin L Panciera T Soligo S | 2014 | Cell2014，158，1： | 1 |
| 14 | Differentiation and expansion of endoulelial cells from human bone marrow CD133 + cells显示文摘 | Quirici N Soligo D Canevs L | 2001 | Br J Haematol2001，115，： | 1 |
| 15 | Differentiation and expansion of endothelial cells from human bone marrow CD133 ^+ cells 显示文摘 | Quirici N Soligo D Ganeva L | 2001 | Br J Heamatol2001，115，： | 1 |
| 16 | Economic development and End-Use energy demand显示文摘 | R SOLIGO | 2001 | The Energy Journal2001，22，2： | 1 |
| 17 | Functional and anatomical outcome of anterior and posterior vaginal prolapse repair with prolene mesh显示文摘 | Milani R Salvatore S Soligo M | 2005 | B JOG Int J Obstet Gynaecol2005，112，1： | 1 |
| 18 | bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells显示文摘 | Delia O Aiello O Soligo D | 1992 | Blood1992，79，： | 1 |
| 19 | YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt re- sponse显示文摘 | Azzolin L Panciera T Soligo S | 2014 | Cell2014，158，1： | 1 |
| 20 | Correcting for interference in soil radon flux measurements显示文摘 | Tuccimei P Soligo M | 2008 | Radiation Measurements2008，43，1： | 1 |
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