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| 1 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 2 | Middle infrared muhispectral aircraft scanner data: analysis for geological applications显示文摘 | Kahle A B Madura D P Soha J M | 1980 | Applied Optics1980，19，： | 1 |
| 3 | Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the Rho A-exreacellular signal-regulated kinase serum response factor signaling pathway显示文摘 | Soha M Obata K Ickihara S | 2006 | Clinical & Experi Pharmac Physiol2006，33，12： | 1 |
| 4 | Middle infrared multispectral aircraft scanner data: Analysis for geological applications显示文摘 | Kahle A B Madura D P Soha J M | 1980 | Applied Optics1980，19，： | 1 |
| 5 | The Use of Third Party Logistics Services:a Malaysian Perspective显示文摘 | SOHAIL M S SOHA A S | 2003 | Technovation2003，23，5： | 1 |
| 6 | Middle Infrared Muhispeetral Aircraft Scanner Data:Analysis for Geological Applications显示文摘 | Madura D P Soha J M | 1980 | Applied Optics1980，19，： | 1 |
| 7 | Middle Infrared Multi- spectral Aircraft Scanner Data: Analysis for Geologic Applications显示文摘 | Kahle A B Madura D P Soha J M | 1980 | Applied Optics1980，19，： | 1 |
| 8 | Middle infrared muhispectral aircraft scanner data: analysis for geological applications显示文摘 | Kahle A B Madura D P Soha J M | 1980 | Applied Optics1980，19，14： | 1 |
| 9 | Middle infrared multispectral aircraft scanner data:Analysis for geological applications显示文摘 | Kahle A B Madura D P Soha J M | | 0，，14： | 1 |
| 10 | Assesment of polyunsaturated fatty acids in cord blood of infants of diabetic mothers显示文摘Objective:To assess whether infants of diabetic mothers [pre pregnancy diabetics(PPD)and gestational diabetics mellitus(GDM)] have compromised arachidonic and docosahexaenoic acids in their plasma and the relationship with deficiency of the same compounds in their mothers.Methods:This study was conducted on 30 diabetic mothers(both PPD and GDM)and their infants.Twenty healthy infants and their mothers with age and sex matched were included as controls.All infant(of diabetic and non diabetic mothers)were subjected to assessment of APGAR Scoring,thorough history taking and anthropometric measures.Lipid profile components as well as polyunsaturated fatty acids(PUFA)were assessed in diabetic GDM and PPD and non diabetic mothers as well as in their babies.Results:High-density lipoproteir(HDL)level was found to be significantly lower in diabetic mothers(specially those with PPD)compared to non diabetic ones,whereas no significant difference was found between babies of the two groups.Also,the current study revealed that diabetic mothers(GDM and PPD)and their babies had significantly higher levels of PUFA precursors linoleic acids(LA)and alpha linoleic acids(ALA).PUFA arachidonic acid(AA)and docosahexaenoic acids(DHA)were found to be significantly lower in diabetic mothers(GDM and PPD)compared to non diabetic mothers,and same results were found in the babies of the two groups.Conclusion:Neonates with diabetic mothers(both GDM and PPD)have highly compromised plasma levels of AA and DHA PUFA,which affects the child well being by far,and produces hazardous multi-system complications on the long run. | Galila M Mokhar Soha M Abd El Dayem Nermine H Sayed Sohair abd El Maksod Manal El Shamaa Hani M El Mikaty | 2009 | 海南医学院学报2009，15，11： | 0 |
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