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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Regression of tumors in mice vaccinated with professional antigen- presenting cells pulsed with tumor extracts显示文摘 | Nair SK Snyder D Rouse BT | 1997 | Int J Cancer1997，70，6： | 2 |
| 3 | Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo 显示文摘 | Boczkowski D Nair SK Snyder D | 1996 | J Exp Med1996，184，： | 2 |
| 4 | Analytical methods for detection of selected estrogenic compounds in aqueous mixtures 显示文摘 | Snyder S A Keith T L Verbrugge D A | 1999 | Environ Sci Technol1999，33，16： | 2 |
| 5 | A fuel dryness index for grassland fire danger assessment 显示文摘 | SNYDER R L SPANO D DUCE P | 2006 | Agricultural and Forest Meteorology2006，139，： | 1 |
| 6 | A Necessary And Sufficient Con- dition For Quantization Errors To Be Uniform And White 显示文摘 | Sripad A B Snyder D L | 1977 | IEEE Transactions on Acoustics Speech Signal Pro- cessing1977，25，3： | 1 |
| 7 | The design of systems to control actively periodic sound transmission into enclosed spaces, Part II: Mechanisms and trends显示文摘 | Snyder S D Hansen C H | 1994 | J Sound and Vibration1994，170，4： | 1 |
| 8 | Research management team(RMT) : A model for research support -services at Duke Univelity显示文摘 | Snyder D C Epps S Berestbrd H F el al | 2012 | Clinical and Translational Science2012，5，6： | 1 |
| 9 | Redescription of the frog bladder fluke Gorgoderina attenuata from the north- ern leopard frog, Rana pipiens 显示文摘 | Bolek M G Snyder S D Janovy J Jr | 2009 | J Parasitol2009，95，3： | 1 |
| 10 | Fear fosters flight: A mechanism for fear contagion when perceiving emotion expressed by a whole body显示文摘 | De Gelder B Snyder J Greve D | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，16： | 1 |
| 11 | Tribology of water and oil repellent sol-gel coatings for optical applications显示文摘 | KESSMAN A HUCKABY D SNYDER C | 2009 | Wear2009，267，1： | 1 |
| 12 | Modified iterative methods for consistent linear system显示文摘 | GUNAWARDENA A D JAIN S K SNYDER L | 1991 | Linear Algebra and Its Applications1991，154，1： | 1 |
| 13 | Laparoscopic anatomy of the equine abdomen 显示文摘 | Galuppo L D Snyder J R Pascoe J R | 1995 | Am J Vet Res1995，56，4： | 1 |
| 14 | Reevaluation of PbTel -xlx as High Performance n-type Thermoelectric material 显示文摘 | LaLonde A D Pei Y Snyder G J | 2011 | Energy & Envi- ronmental Science2011，4，6： | 1 |
| 15 | Potential errors in measuring nitrogen content of soils low in nitrogen显示文摘 | Wang D Snyder M C Bormann F H | 1993 | Soil Science Society of America Journal1993，57，6： | 1 |
| 16 | Four viral genes indepen?dently contribute to attenuation of live influenza NAnn Arbor/6/60 (H2N2) cold-adapted re-assortant virus vaccines 显示文摘 | Snyder MH Betts RF DeBorde D | 1988 | Journal ofVirol?ogy1988，62，2： | 1 |
| 17 | Protected paste volume in concrete exten- sion to internal curing using saturated lightweight fine aggregate显示文摘 | BENTZ D P SNYDER K A | 1999 | Cement and Concrete Research1999，，29： | 1 |
| 18 | Broadband receiver response from dual-streamer data and applications in deep reflection seismology显示文摘 | Singh S C Hobbs R W Snyder D B | | 0，，01： | 1 |
| 19 | Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer’s Disease显示文摘 | Masaaki Takahashi Sylvain Doré Christopher D Ferris Taisuke Tomita Akira Sawa Herman Wolosker David R Borchelt Takeshi Iwatsubo Seong-Hun Kim Gopal Thinakaran Sangram S Sisodia Solomon H Snyder | 2000 | Neuron2000，，2： | 1 |
| 20 | Hopeful choices: A school counselorg guide to hope theory显示文摘 | Snyder C R Feldman D Shorey H Rand K | 2002 | Journal of Personality2002，5，5： | 1 |
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