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您的检索式：作者名="Smita Patil"
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| 1 | Characterising acute ischaemic stroke thrombi:insights from histology,imaging and emerging impedance-based technologies显示文摘Treatment of acute ischaemic stroke(AIS)focuses on rapid recanalisation of the occluded artery.In recent years,advent of mechanical thrombectomy devices and new procedures have accelerated the analysis of thrombi retrieved during the endovascular thrombectomy procedure.Despite ongoing developments and progress in AIS imaging techniques,it is not yet possible to conclude definitively regarding thrombus characteristics that could advise on the probable efficacy of thrombolysis or thrombectomy in advance of treatment.Intraprocedural devices with dignostic capabilities or new clinical imaging approaches are needed for better treatment of AIS patients.In this review,what is known about the composition of the thrombi that cause strokes and the evidence that thrombus composition has an impact on success of acute stroke treatment has been examined.This review also discusses the evidence that AIS thrombus composition varies with aetiology,questioning if suspected aetiology could be a useful indicator to stroke physicians to help decide the best acute course of treatment.Furthermore,this review discusses the evidence that current widely used radiological imaging tools can predict thrombus composition.Further use of new emerging technologies based on bioimpedance,as imaging modalities for diagnosing AIS and new medical device tools for detecting thrombus composition in situ has been introduced.Whether bioimpedance would be beneficial for gaining new insights into in situ thrombus composition that could guide choice of optimum treatment approach is also reviewed. | Smita Patil Jean Darcourt Pierluca Messina Franz Bozsak Christophe Cognard Karen Doyle | 2022 | Stroke & Vascular Neurology2022，7，4： | 3 |
| 2 | Effect of Ipomea carnea Jacq. flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats显示文摘AIM:To investigate the active chloroform fraction of the ethanol extract of Ipomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats.METHOD:Except for the control group,all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diisocyanate(TDI) for 7 days.One week after second sensitization,all of the rats were provoked with 5 μL of 5% TDI to induce airway hypersensitivity.After the last challenge,blood and bronchoalvelor lavage(BAL) fluid were collected and subjected to total and differential leucocytes count.Flash chromatography was performed on the most active chloroform fraction to isolate an individual component.RESULTS:Treatment with the ethanolic extract and its chloroform fraction at an oral dose of 200 mg·kg-1 showed a significant decrease in circulating neutrophil and eosinophil in blood and BAL as compared with standard dexamethasone(DEXA).The structure of the compound obtained from chloroform fraction of Ipomea carnea was elucidated as stigmast-5,22-dien-3β-ol on the basis of spectral data analysis.CONCLUSION:The chloroform fraction was found to be more effective to suppress airway hyper reactivity symptoms,and decreased count of both total and differential inflammatory cells. | Jain Smita Patil U.K. | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 0 |
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