|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stem cells for liver tissue repair:Current knowledge and perspectives显示文摘Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated. | Philippe A Lysy David Campard Fran oise Smets Mustapha Najimi Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，6： | 22 |
| 2 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 3 | Recent development in aluminium alloys for the automotive industry显示文摘 | W.S Miller L Zhuang J Bottema A.J Wittebrood P De Smet A Haszler A Vieregge | 2000 | Materials Science & Engineering A2000，，1： | 3 |
| 4 | Review on uremic toxins:classification,concentration,and interindividual varia-bility显示文摘 | Vanholder R De Smet R Glorieux G Argiles A Baur-meister U? Brunet P | 2003 | Kidney Int2003，63，： | 1 |
| 5 | Autotrophic nitrogenremoval in a membrane-aerated biofilm reactor under continuousaeration : a demonstration 显示文摘 | Gilmore K R Terada A Smets B F ef al | 2013 | Environmental EngineeringScience2013，30，1： | 1 |
| 6 | Earthquakes and crush syndrome casuahies : lessons learned from the Kashmir disaster 显示文摘 | Vanhnlder R Van-der-Tol A De Smet M | 2007 | Kidney Int2007，71，1： | 1 |
| 7 | Activity of new juvenile hormone analogues on a stored food insect, Tribolium confusum (J, du Val) (Coleoptera: Tenebrionidae) 显示文摘 | Smet H Rans M Loof A De | 1989 | J Stored Prod1989，25，： | 1 |
| 8 | Selective decontamination of the oral and digestive tract in surgical versus non-surgical patients in intensive care in a cluster-randomized trial显示文摘 | Melsen W G De Smet A M Kluytmans J A | 2012 | Br J Surg2012，99，2： | 1 |
| 9 | Recent development in aluminium alloys for the automotive industry显示文摘 | MILLER W S ZHUANG L BOTTEMA J WITTEBROOD A J SMET P D HASZLER A VIEREGGE A | 2000 | Material Science and Engineering A2000，280，3： | 1 |
| 10 | Cognitive and affective disturbances following focal cerebellar damage in adults:a neuropsychological and SPECT study显示文摘 | Baillieux H De Smet HJ Dobbeleir A | 2010 | Cortex2010，46，： | 1 |
| 11 | Managing sever endophthalmitis with the use of an endoscope显示文摘 | SMET D CARLBORG E A | 2005 | Retina2005，25，8： | 1 |
| 12 | Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy:the MIVI Ⅰ trial显示文摘 | de Smet MD Gandorfer A Stalmans P | | 0，，07： | 1 |
| 13 | Introduc- tion to the pharmacoeconomics of herbal medicines 显示文摘 | De Smet PA Bonsel G Van der Kuy A | 2000 | Pharmacoeconomics2000，18，1： | 1 |
| 14 | Deeontamination of the digestive tract and oropharynx in ICU patients显示文摘 | De Smet A M G A Klu~tmans J A J W Cooper B S | 2009 | N Engl J Med2009，360，1： | 1 |
| 15 | 查看详情显示文摘 | Van de Vyver S Thomas J Geboers J Keyzer S Smet M Dehaen W Jacobs P A Sels B F | | 0，，09： | 1 |
| 16 | Complex compartmental behavior of small water - soluble uremic retention solutes: evaluation by direct measurements in plasma and erythrocytes显示文摘 | Eloot S Torremans A De Smet R | 2007 | Am J Kidney Dis2007，50，2： | 1 |
| 17 | On the growth mechanism of a-Si : H 显示文摘 | KESSELSW M M SMETS A H M MARRA D C | 2001 | Thin Solid Films2001，383，15： | 1 |
| 18 | Case report 611: Subperisteal aneurysmal bone cyst of tibia 显示文摘 | Bumstein M I De Smet A A Hafez G R | 1990 | Skeletal Radiol1990，19，： | 1 |
| 19 | The leaching of sodiumaluminosilicate glasses studied by secondary ion mass spec-trometry 显示文摘 | SMETS BMJ LOMMEN T P A | 1982 | Phys Chem Glasses1982，23，3： | 1 |
| 20 | Nitrogen Removal from digested black water by one -stage partial nitritation and anammox 显示文摘 | Vlaeminck S E Terada A Smets B F | 2009 | Environment Science and Technology2009，43，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员