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| 1 | Predicting functional outcome of ischemic stroke patients in Romania based on plasma CRP, sTNFR-1, D-Dimers, NGAL and NSE measured using a biochip array显示文摘在服的局部缺血,涉及各种各样的病理学的小径的多重 biomarkers 的评估是在甚至从疾病的早阶段估计病人的结果的一个有用工具。在这研究,我们在局部缺血的尖锐阶段调查了煽动性的地位, neuronal 破坏和第二等的纤维蛋白溶解作用的 5 外部 biomarkers 的一块面板的用途,并且在 ischemic 击以后在功能的结果上评估了这些 biomarkers 的影响。5 biomarkers (血浆 CRP, D-Dimers, sTNFR-1, NGAL 和 NSE ) 用一种生物晶片数组技术被测量。在罗马尼亚的八十九个病人用在 ischemic 击以后在 3 个月评估的修改 Rankin 规模被划分成 2 亚群;相反的功能的结果上的分析 biomarkers 的可能的影响被二项式的逻辑回归测试。有相反的结果的亚群有 CRP, NGAL, sTNFR-1 和 D-dimers 的更高的集中,但是 CRP 和 NGAL 价值不在二亚群之间是统计上不同的。univariate 血浆 biomarkers 的逻辑回归分析揭示了那 CRP, D-Dimers, NGAL, sTNFR-1 是相反的临床的结果的重要预言者。在 D-Dimers 和 sTNFR-1 的情况中,我们注意了一个增加的辨别能力(对基线临床的模型) 向统计含义与一个趋势分类差的功能的结果。在 ischemic 击的尖锐阶段期间, CRP, D-Dimers 和 sTNFR-1 的血浆集中在相反的结果病人被提高。D-Dimers 和 sTNFR-1 是在在 ischemic 击以后的 3 个月的差的结果的独立预言者。生物晶片数组技术提供可能性同时测量涉及多重 pathophysiological 小径的几个参数,在小样品卷。 | Adina HUTANU Mihaela IANCU Rodica BALASA Smaranda MAIER Minodora DOBREANU | 2018 | Acta Pharmacologica Sinica2018，39，7： | 25 |
| 2 | Real-time sono-elastography in the diagnosis of diffuse liver diseases显示文摘AIM: To analyze whether computer-enhanced dynamic analysis of elastography movies is able to better characterize and differentiate between different degrees of liver fibrosis. METHODS: The study design was prospective. A total of 132 consecutive patients with chronic liver diseases and healthy volunteers were examined by transabdominal ultrasound elastography. All examinations were done by two doctors.RESULTS: Due to the limitations of the method, we obtained high-quality elastography information in only 73.48% of the patients. The κ-means clustering method was applied to assess the inter-observer diagnosis varia- bility, which showed good variability values in accordance with the experience of ultrasound examination of every observer. Cohen’sκ test indicated a moderate agreement between the study observers (κ = 0.4728). Furthermore, we compared the way the two observers clustered the patients, using the test for comparing two proportions (t value, two-sided test). There was no statistically significant difference between the two physicians, regardless of the patients’ real status. CONCLUSION: Transabdominal real-time elastography is certainly a very useful method in depicting liver hard- ness, although it is incompletely tested in large multicenter studies. | Dan Ionut Gheonea Adrian S ǎftoiu Tudorel Ciurea Florin Gorunescu Sevastita Iordache Gabriel Lucian Popescu Smaranda Belciug Marina Gorunescu Larisa Sǎndulescu | 2010 | World Journal of Gastroenterology2010，16，14： | 9 |
| 3 | Could the burden of pancreatic cancer originate in childhood?显示文摘The presence of pancreatic cancer during childhood is extremely rare,and physicians may be tempted to overlook this diagnosis based on age criteria.However,there are primary malignant pancreatic tumors encountered in pediatric patients,such as pancreatoblastoma,and tumors considered benign in general but may present a malignant potential,such as the solid pseudo-papillary tumor,insulinoma,gastrinoma,and vasoactive intestinal peptide secreting tumor.Their early diagnosis and management are of paramount importance since the survival rates tend to differ for various types of these conditions.Many pediatric cancers may present pancreatic metastases,such as renal cell carcinoma,which may evolve with pancreatic metastatic disease even after two or more decades.Several childhood diseases may create a predisposition for the development of pancreatic cancer during adulthood;hence,there is a need for extensive screening strategies and complex programs to facilitate the transition from pediatric to adult healthcare.Nevertheless,genetic studies highlight the fact the specific gene mutations and family aggregations may be correlated with a special predisposition towards pancreatic cancer.This review aims to report the main pancreatic cancers diagnosed during childhood,the most important childhood diseases predisposing to the development of pancreatic malignancies,and the gene mutations associates with pancreatic malignant tumors. | Smaranda Diaconescu Georgiana Emmanuela Gîlcă-Blanariu Silvia Poamaneagra Otilia Marginean Gabriela Paduraru Gabriela Stefanescu | 2021 | World Journal of Gastroenterology2021，27，32： | 3 |
| 4 | Split-dose or hybrid nonsteroidal anti-inflammatory drugs and Nacetylcysteine therapy for prevention of post-retrograde cholangiopancreatography pancreatitis显示文摘BACKGROUND Despite significant technical and training improvements, the incidence of postendoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP) has not significantly dropped. Although many studies have evaluated the efficacy of various agents, e.g. nonsteroidal anti-inflammatory drugs, octreotide,antioxidants, administered via various dosages, routes(oral, intrarectal or parenteral), and schedules(before or after the procedure), the results have been conflicting.AIM To evaluate efficacy of three pharmacologic prophylactic methods for prevention of PEP.METHODS In this prospective, single-center randomized trial, patients who underwent firsttime ERCP for choledocholithiasis were randomly assigned to three groups. The first group received 600 mg N-acetylcysteine 15 min prior to ERCP, and perrectum administration of 50 mg indomethacin both prior to and after completion of the ERCP. The second group was administered only the 50 mg indomethacin per-rectum both prior to and after the ERCP. The third group was administeredper-rectum 100 mg indomethacin only after the ERCP, representing the control group given the guideline-recommended regimen. The primary end-point was PEP prevention.RESULTS Among the total 211 patients evaluated during the study, 186 fulfilled the inclusion criteria and completed the protocol. The percentages of patients who developed PEP in each of the three groups were not significantly different(χ2 =2.793, P = 0.247). Among the acute PEP cases, for all groups, 14 patients developed mild pancreatitis(77.77%) and 4 moderate. No severe cases of PEP occurred, and in all PEP cases the resolution was favorable. No adverse events related to the medications(digestive hemorrhage, rectal irritation, or allergies)occurred.CONCLUSION The efficacies of split-dose indomethacin and combined administration(Nacetylcysteine with indomethacin) for preventing PEP were similar to that of the standard regimen. | Laura Pavel Gheorghe Gh Balan Alexandra Nicorescu Georgiana Emmanuela Gilca-Blanariu Catalin Sfarti Stefan Chiriac Smaranda Diaconescu Vasile Liviu Drug Gheorghe Balan Gabriela Stefanescu | 2019 | World Journal of Clinical Cases2019，7，3： | 3 |
| 5 | New technique for the synthesis of polyphosphoesters 显示文摘 | Smaranda I Ecaterina A Aurelia V | 2011 | Macrorm:lecular Reseawh2011，19，11： | 1 |
| 6 | Neural networks and their application in credit risk assessment - - Evidence from the Romanian market 显示文摘 | Smaranda | | Technological and Economic Development of Economy0，，： | 1 |
| 7 | Polymers containing phosphorus groups and polythers:Frum synthesis to appli- cation 显示文摘 | Smaranda Iliescu Leire Zubizarreta Nicoleta Plesu | 2012 | Chemistry Central Journal2012，6，1： | 1 |
| 8 | Comparative study on hydrolysis of 2-chloroethylphosphonic acid dialkyiesters 显示文摘 | Gheorghe I Adrian C Smaranda I | 2004 | Revue Roumaine de Chimie2004，49，6： | 1 |
| 9 | Error-correction learning for artifi- cial neural networks using the bayesian paradigm applica- tion to automated medical diagnosis显示文摘 | Smaranda B Florin G | 2014 | Journal of Bio- medical Informatics2014，52，32： | 1 |
| 10 | The last bite of the BIT s-supremacy of EU law versus investment treaty arbitration显示文摘 | SMARANDA MIRON | 2014 | European Law Journal2014，，5： | 1 |
| 11 | Unconventional method used in synthesis of polyphosphoesters显示文摘 | Smaranda I Aurelia P Nicoleta P | 2009 | Polymer Bulletin2009，63，48： | 1 |
| 12 | Soil and groundwater cleanup:benefits and limits of emerging technologies显示文摘 | Caliman F A Robu B M Smaranda C | 2011 | Clean Technologies and Environmental Policy2011，13，2： | 1 |
| 13 | Bioavailability processes for contaminants in soilsand their use in risk assessment显示文摘 | HLIHOR R M APOSTOL L C SMARANDA C | 2009 | Environmentalengineering and management journal2009，8，5： | 1 |
| 14 | Study of the natural ageing of PVC insulation for electrical cables显示文摘 | Mihai Brebu Cornelia Vasile Smaranda Rovana Antonie | 2000 | Polymer Degradation and Stability2000，67，： | 1 |
| 15 | Neuraxial hematoma after combined regional anesthesia:conservative resolution显示文摘 | Martin S Smaranda A Archilla J | 2005 | Rev Esp Anestesiol Reanim2005，52，： | 1 |
| 16 | Electromagnetic Actuator with Magnet-ic Stored Energy显示文摘 | Constantin Nitu A Gheorghe Tu-luca B | 2007 | Journal of Materials Processing Technology2007，181，： | 1 |
| 17 | Study of the natural ageing of PVC insulation for electrical cables显示文摘 | MIHAI Brebu CORNELIA Vasile SMARANDA Rovana Antonie | 2000 | Polymer and Stability2000，67，： | 1 |
| 18 | Studies on sorption of congo red from aqueous solution onto soil显示文摘 | Smaranda C Gavrilescu M Bulgariu D | | 0，，： | 1 |
| 19 | Study about customer preferences in using online tourism products 显示文摘 | Smaranda Cosma | 2012 | Procedia Economics and Finance2012，，3： | 1 |
| 20 | Influence of the diet-ary protein level on the quality of cow milk显示文摘 | Smaranda Pop Nicolae M Dragomir C | 2001 | Archiva Zootechni-ca2001，6，： | 1 |
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