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| 1 | 2022年WHO甲状腺肿瘤分类概述显示文摘2022年WHO第5版甲状腺肿瘤分类按细胞起源、病理特征、分子分型及生物学行为,分为良性、低危组和恶性。新分类变化不少,作者做了综述。将发育异常甲状舌管纳入;为避免结节性甲状腺肿定义为增生性、肿瘤性或矛盾的“腺瘤样增生”,编委会达成共识,命名为甲状腺滤泡结节性病变(FND)。基于分子谱和侵袭性,多种形态亚型的甲状腺乳头状癌(PTC)代表了BRAF样癌(浸润性生长、核非典型明显);而包裹型浸润性乳头状癌滤泡变异型/[IEFVPC,分子检测证实与滤泡性甲状腺癌(FTC)关系密切,不再归于PTC]与FTC代表RAS样癌(膨胀性生长、核非典型轻度)。 | Baloch ZW Asa SL Barletta JA 方三高(译) 魏建国(校) | 2022 | 诊断病理学杂志2022，29，12： | 63 |
| 2 | Late Mesozoic crust-mantle interaction in southeastern Fujian——Isotopic evidence from the Pingtan igneous complex显示文摘UNDERPLATING Of mantle-derived basaltic magma and interacting with the lower crust materials are believed to be an important mechanism for the growth and transformation of the crust. | Dong, CW Zhou, XM Li, HM Ren, SL Zhou, XH | 1997 | Chinese Science Bulletin1997，42，6： | 23 |
| 3 | Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy显示文摘AIM: To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy.METHODS: Consecutive patients who underwent capsule endoscopy du ring the 16-mo study period were either given 250 mg oral erythromycin, 1 h prior to swallowing the capsule endoscope or nothing. The gastric and small bowel transit time, and the small bowel image quality were compared.RESULTS: Twenty-four patients received oral erythromycin whereas 14 patients were not given any prokinetic agent.Patients who received erythromycin had a significantly lower gastric transit time than control (16 min vs70 min, P= 0.005),whereas the small bowel transit time was comparable between the two groups (227 min vs183 min, P = 0.18).Incomplete small bowel examination was found in three patients of the control group and in one patient of the erythromycin group. There was no significant difference in the overall quality of small bowel images between the two groups. A marked reduction in gastric transit time was noted in two patients who had repeat capsule endoscopy after oral erythromycin.CONCLUSION: Use of oral erythromycin significantly reduces the gastric transit time of capsule endoscopy. | Wai K Leung Francis KL Chan Sara SL Fung Mei-Yin Wong Joseph JY Sung | 2005 | World Journal of Gastroenterology2005，11，31： | 16 |
| 4 | Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation显示文摘AIM: To evaluate the outcome of transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC) <5 cm in diameter eligible for radiofrequency ablation (RFA).METHODS: The treatment-related mortality, morbidity,long-term survival, and prognostic factors of HCC patients who had TACE and fulfilled the present inclusion criteria for RFA were evaluated.RESULTS: Of the 748 patients treated with TACE between January 1990 and December 2002, 114 patients were also eligible for RFA. The treatment-related mortality and morbidity were 1% and 19%, respectively. Survival at 1, 3, and 5 years was 80%, 43%, and 23%, respectively. Older age and a high albumin level were associated with a better survival, whereas a high α-fetoprotein level (AFP) and the size of the largest tumor >3 cm in diameter were adverse prognostic factors in multivariate analysis.CONCLUSION: The morbidity, mortality, and survival data after TACE for small HCCs eligible for RFA are comparable to those reported after RFA in the literature. Our data suggest the need for a randomized comparison of the two treatment modalities for small HCCs. | Mike SL Liem Ronnie TP Poon Chung Mau Lo Wai Kuen Tso Sheung Tat Fan | 2005 | World Journal of Gastroenterology2005，11，29： | 15 |
| 5 | Prognostic significance of annexin VII expression in glioblastomas multiforme in humans显示文摘OBJECT:Glioblastoma multiforme(GBM)is the most common and lethal primary brain tumor in adults.It isnearly uniformly fatal,with a median survival time of approximately l year,despite modem treatment modalities.Nevertheless,a range of survival times exists around this median.Efforts to understand why some patients livelonger or shorter than the average may provide insight into the biology of these neoplasms.The annexin VII(ANX7)gene is located on the human chromosome 10q21,a site long hypothesized to harbor tumor | Hung KS Howng SL | 2003 | 中国神经肿瘤杂志2003，1，4： | 14 |
| 6 | 坏死性筋膜炎病人的急救与护理显示文摘 | DeBoer SL 贾向春 李娜 | 2001 | 国外医学(护理学分册)2001，20，9： | 14 |
| 7 | Enzymohistochemical study on burn effect on rat intestinal NOS显示文摘INTRODUCTION The blood irrigate flow obstruction,especially thegastrointestinal(GI)ischemia,is the main factorof the damage to the digestive tract caused byserious burns.The effect of GI ischemia on thewhole body is extensive and profound,which notonly causes the increase of intestinal permeabilityand the movement of bacteria and toxin in theintestinal cavity,but releases a large quantity ofinflammatory media.Neuroendocrine element | Wang QG He LY Chen YW Hu SL | 2000 | World Journal of Gastroenterology2000，6，3： | 12 |
| 8 | 孕前血压及其到妊娠早期的变化:先兆子痫和妊娠期高血压的早期危险因素显示文摘先兆子痫和妊娠期高血压是常见的妊娠并发症,与母婴发病率显著相关。尽管对怀孕期间的危险因素进行了广泛的研究,但大多数患妊娠期高血压疾病的妇女并不被认为是高风险的,预防措施仍不清楚。研究者评估了妊娠前的血压及其到妊娠早期的变化,将其作为妊娠高血压疾病发展新的危险标志。 | 刘青(译) 刘莉(摘/审校) Nobles CJ Mendola P Mumford SL Silver RM Kim K Andriessen VC Connell M Sjaarda L Perkins NJ Schisterman EF | 2020 | 中华高血压杂志2020，28，12： | 12 |
| 9 | Emerging role of Hippo pathway in gastric and othergastrointestinal cancers显示文摘More evidence has underscored the importance of Hippo signaling pathway in gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. Yes-associated protein 1(YAP1) and its close paralog TAZ, transcriptional co-activator with a PDZbinding motif, function as key effectors negatively controlled by the Hippo pathway. YAP1/TAZ exerts oncogenic activities by transcriptional regulation via physical interaction with TEAD transcription factors. In various cancers, Hippo pathway cross-talks with pro- or anti-tumorigenic pathways such as GPCR, Wnt/β-catenin, Notch and TGF-β signaling and is deregulated by multiple factors including cell density/junction and micro RNAs. As YAP1 expression is significantly associated with poor prognosis of gastric and other gastrointestinal cancers, detailed delineation of Hippo regulation in tumorigenesis provides novel insight for therapeutic intervention. In current review, we summarized the recent research progresses on the deregulation of Hippo pathway in the gastrointestinal tract including stomach and discuss the molecular consequences leading to tumorigenesis. | Wei Kang Alfred SL Cheng Jun Yu Ka Fai To | 2016 | World Journal of Gastroenterology2016，22，3： | 11 |
| 10 | High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells显示文摘 | Hua LI Amy LAM Ai-min XU Karen SL LAM Sookja KIM CHUNG | 2010 | Acta Pharmacologica Sinica2010，31，5： | 10 |
| 11 | Study of T-lymphocyte subsets,nitric oxide,hexosamine and Helicobacter pylori infection in patients with chronic gastric diseases显示文摘INTRODUCTIONChronic gastritis(CG)and peptic ulcer(PU)arefrequently-occurring diseases.It is now well recognizedthat Helicobacter pylori(Hp)is a major factor that leadsto CG and PU.In order to study the relationshipamong T lymphocyte subsets,NO,Hexosamine and | Zhang H Jiang SL Yao XX | 2000 | World Journal of Gastroenterology2000，6，4： | 10 |
| 12 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 13 | 海洋天然产物的药物开发显示文摘从海洋天然产物中发现药物近年来再次引起广泛关注。2004年12月,美国FDA批准了第1个源自海洋生物的止痛药齐考诺肽(ziconotide,Prialt),用于治疗疼痛。2007年10月欧盟了第1个抗癌海洋药物海鞘素(ecteinascid in,Yondelis)。本文将举例说明影响药物发现的因素和要完成一种化合物从海洋到临床试验的飞跃会遇到的各种困难,展望未来,分析海洋药物的乐观前景。 | 王燕 乔善义 Mlinski TF Dalisay DS Lievens SL | 2009 | 国际药学研究杂志2009，36，4： | 8 |
| 14 | Protective effect of electroacupuncture and moxibustion on gastric mucosal damage and its relation with nitric oxide in rats显示文摘INTRODUCTION Gastric mucosal injury is one of the common disorders,there are many reports subjicted to its pathogenesis treatment and prevention.We investigated the protective effect | Pei WF Xu GS Sun Y Zhu SL Zhang DQ | 2000 | World Journal of Gastroenterology2000，6，3： | 8 |
| 15 | 骨折相关性感染定义的共识显示文摘骨折相关性感染(fracture related infection,FRI)是创伤骨科一种常见的严重并发症.迄今为止,尚无明确定义,因此很难对该并发症带来的影响进行准确评估和对现有的研究展开比较.为解决这一难题,在AO基金会的支持下,我们成立了一个由科学家和医学专家组成的专家组,旨在对FRI定义达成的共识. | Metsemakers WJ Morgenstern M McNally MA Moriarty TF McFadyen I Scarborough M Athanasou NA Ochsner PE Kuehl R Raschke M Borens O 谢肇 Velkes S Hungerer S Kates SL Zalavras C Giannoudis PV Richard RG Verhofstad MH 喻胜鹏 孙东 汪小华 | 2018 | 中华骨科杂志2018，38，9： | 8 |
| 16 | 非甾体抗炎药(包括环氧化酶-2抑制剂)在治疗膝关节骨关节炎所致疼痛中的作用:随机安慰剂对照临床试验的汇总分析显示文摘目的评价包括选择性环氧化酶2抑制剂(昔布类)在内的非甾体抗炎药(NSAIDs)在膝关节骨关节炎患者中的镇痛作用。试验设计对随机安慰剂对照的临床试验进行系统回顾和汇总分析。文献回顾本项研究共对23项研究中的10845例患者进行了回顾性分析,患者的平均年龄为62.5岁,其中7807例患者接受了适当剂量的NSAIDs治疗,3038例患者接受了安慰剂治疗。患者入选时,经100mm视觉模拟尺(VAS)测定的权重疼痛分数基线的平均值为64.2mm,症状存在的平均时间为8.2年。主要观察指标总体疼痛程度的变化。结果各项临床试验的方法学质量可以接受,但是其中13项试验在随机化之前排除了对NSAIDs治疗没有反应的患者。一项试验报告了长期疗效的数据,结果提示治疗1~4年期间,NSAIDs的疗效与安慰剂相当。汇总所有入选试验的数据显示,在治疗2~13周后疼痛程度的差值为VAS10.1mm(95%可信区间为7.4~12.8),优于安慰剂15.6%。来自不同试验所得到的结果之间差异很大,随机效应模型显示,疼痛改善的效应量为0.32(0.24~0.39)。10项没有排除对NSAIDs治疗没有反应患者的试验中,结果比较一致,疼痛改善的效应量为0.23(0.15~0.31)。结论NSAIDs能够在短期内减轻骨关节炎患者的膝关节疼痛,其疗效略优于安慰剂,但是现在的分析不支持对这种疾病长期应用NSAIDs。由于口服NSAIDs可以导致严重的不良反应,因此只推荐有限制的使用。 | Jan Magnus Bjordal Anne Elisabeth Ljunggren Atle Klovning Lars SlΦdal 张卓莉 | 2005 | 英国医学杂志中文版2005，8，3： | 6 |
| 17 | 凋落:Bcl-2是程序性细胞死亡的关键蛋白显示文摘凋落是一种程序性细胞死亡,一种有规律的细胞死亡形式,有别于激发性细胞死亡。程序性细胞死亡的细胞具如下特征:细胞皱缩、染色质凝聚、细胞膜呈典型的外突。在 DNA 水平上,通过 Mg2+/Ca2+相关的核酸内切酶,裂解为180个碱基对大小的若干片断。在无胞浆成分溢出的情况下。 | M.Amling M.Psl I.Bsler G.Delling 阮幼冰 | 1996 | 德国医学1996，13，1： | 6 |
| 18 | 肝细胞中Steap3敲除通过抑制TAK1保护肝脏缺血再灌注损伤显示文摘【据《Hepatology》2020年3月报道】题:肝细胞中Steap3敲除通过抑制TAK1保护肝脏缺血再灌注损伤(作者Guo WZ等)肝脏缺血再灌注(I/R)损伤仍然是影响肝移植预后的主要挑战。目前尚无有效的策略来改善肝脏I/R损伤后的肝功能障碍。前列腺六跨膜上皮抗原3(Steap3)是调节铁代谢的关键因子,研究报道其参与多种细胞的免疫和凋亡过程。然而,Steap3在肝脏I/R损伤中的作用仍不清楚。 | 郭文治 GUO WZ FANG HB CAO SL | 2020 | 临床肝胆病杂志2020，36，5： | 5 |
| 19 | Liver fibrogenesis and the role of hepatic stellate cells:new insights and prospects for therapy显示文摘 | Li D Friedman SL | | 0，，： | 5 |
| 20 | The increase of childhood chronic conditions in the united states显示文摘 | Perrin J M Bloom S R Gortmaker SL | 2007 | JA- MA2007，297，24： | 4 |
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