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| 1 | Transporter-Mediated Nuclear Entry of Jasmonoyl-lsoleucine Is Essential for Jasmonate Signaling显示文摘到由直接对荷尔蒙集中作出回应的控制基因表示,动物和植物房间利用了可比较的机制在原子核察觉到小分子的荷尔蒙。这些荷尔蒙的原子入口是否活跃地通常被搬运或消极地扩散了,,,要求了,通过原子毛孔建筑群,仍然保持神秘。这里,我们在 Arabidopsis thaliana 识别了并且描绘 jasmonate transporter, AtJAT1/AtABCG16,哪个展览在原子信封和血浆的意外双本地化膜。我们证明 AtJAT1/AtABCG16 由两个都调停控制 jasmonate 植物激素的细胞质、原子的分区 jasmonic 酸(JA ) 和 jasmonoyl 异白氨酸(JA-Ile ) 的原子流入的细胞的流出,并且为维持批评原子 JA-Ile 集中激活 JA 发信号是必要的。这些结果说明小荷尔蒙分子的那个调停运输的原子条目调整原子荷尔蒙的新机制正在发信号。我们的调查结果提供一条大街开发指向小分子的原子入口的药品的代理人。 | Qingqing Li Jian Zheng Shuaizhang Li Guanrong Huang Stephen J. Skilling Lijian Wang Ling Li Mengya Li Lixing Yuan Pei Liu | 2017 | Molecular Plant2017，10，5： | 6 |
| 2 | Murine study of portal hypertension associated endothelin-1 hypo-response显示文摘AIM:To investigate endothelin-1 hypo-responsive associated with portal hypertension in order to improve patient treatment outcomes.METHODS:Wild type,e NOS-/-and i NOS-/-mice receivedpartial portal vein ligation surgery to induce portal hypertension or sham surgery.Development of portal hypertension was determined by measuring the splenic pulp pressure,abdominal aortic flow and portal systemic shunting.To measure splenic pulp pressure,a microtip pressure transducer was inserted into the spleen pulp.Abdominal aortic flow was measured by placing an ultrasonic Doppler flow probe around the abdominal aorta between the diaphragm and celiac artery.Portal systemic shunting was calculated by injection of fluorescent microspheres in to the splenic vein and determining the percentage accumulation of spheres in liver and pulmonary beds.Endothelin-1 hypo-response was evaluated by measuring the change in abdominal aortic flow in response to endothelin-1 intravenous administration.In addition,thoracic aorta endothelin-1contraction was measured in 5 mm isolated thoracic aorta rings ex-vivo using an ADI small vessel myograph.RESULTS:In wild type and i NOS-/-mice splenic pulp pressure increased from 7.5±1.1 mm Hg and 7.2±1 mm Hg to 25.4±3.1 mm Hg and 22±4 mm Hg respectively.In e NOS-/-mice splenic pulp pressure was increased after 1 d(P=NS),after which it decreased and by 7 d was not significantly elevated when compared to 7 d sham operated controls(6.9±0.6 mm Hg and 7.3±0.8 mm Hg respectively,P=0.3).Abdominal aortic flow was increased by 80%and 73%in 7 d portal vein ligated wild type and i NOS when compared to shams,whereas there was no significant difference in 7 d portal vein ligated e NOS-/-mice when compared to shams.Endothelin-1 induced a rapid reduction in abdominal aortic blood flow in wild type,e NOS-/-and i NOS-/-sham mice(50%±8%,73%±9%and 47%±9%respectively).Following portal vein ligation endothelin-1 reduction in blood flow was significantly diminished in each mouse group.Abdominal aortic flow was reduced by 19%±9%,32%±10%and 9%±9%in wild type,e NOS-/-and i NOS-/-mice respectively.CONCLUSION:Aberrant endothelin-1 response in murine portal hypertension is NOS isoform independent.Moreover,portal hypertension in the portal vein ligation model is independent of ET-1 function. | Nicholas Theodorakis Mary Maluccio Nicholas Skill | 2015 | World Journal of Gastroenterology2015，21，16： | 3 |
| 3 | Tissue transglutaminase and the progression of human renal scarring显示文摘 | Johnson T S El-Koraie A F Skill N J | 2003 | J Am Soc Nephrol2003，14，8： | 1 |
| 4 | Wound healing and defects following northern hardwood pruning显示文摘 | SKILLING D D | 1958 | Journal of Forestry1958，56，1： | 1 |
| 5 | Mapping and spaces显示文摘 | ARHANGEL'SKILL A V | 1966 | Russian Math Surveys1966，21，： | 1 |
| 6 | Effects of two eye drop products on computer users with subjective ocular discomfort显示文摘 | Skilling FC Weaver TA Kato KP | 2005 | Optometry2005，76，： | 1 |
| 7 | Contextualizing SEGUE:Evaluating Residents’ Communication Skills Within the Framework of a Structured Medical Interview显示文摘 | Skillings J L Porcerelli J H Markova T | 2010 | J Grad Med Educ2010，，1： | 1 |
| 8 | Tissue transglutaminase and the progression of human renal scarring显示文摘 | Johnson T S El-Koraie A F Skill N J | 2003 | J Am Soc Nephrol2003，14，8： | 1 |
| 9 | Increases in renal epsilon- (g-glutamyl) -Iysine crosslinks resuit from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy : pathologic implications 显示文摘 | Skill N J Griffin M El Nahas A M | 2001 | Lab Invest2001，81，5： | 1 |
| 10 | Multicenter phase III study of uracil/tegafur and oral leucovin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer显示文摘 | Douillard J Y Hoff P M Skillings J | 2002 | J Clin Oncol2002，20，17： | 1 |
| 11 | Tissue transglutaminase and the progression of human renal scarring显示文摘 | Johnson T S EL-Koraie A F Skill N J | 2003 | J Am Soc Nephol2003，14，8： | 1 |
| 12 | Autotaxin expression and its connection with the TNF-alpha-NF-kappa B axis in human hepatocellular carcinoma显示文摘 | Wu JM Xu Y Skill N J | 2010 | Mol Cancer2010，9，： | 1 |
| 13 | Tissue transglutaminase: a mediator and predictor of chronic allograft nephropathy 显示文摘 | Johnson T S Abo-zenah H Skill N J | 2004 | Transplatation2004，77，11： | 1 |
| 14 | Tissue transglutaminase and the progression of human renal scarring 显示文摘 | Johnson TS El-Koraie AF Skill N J | 2003 | J Am Soc Nephrol2003，14，8： | 1 |
| 15 | Maximum entropy method in image processing显示文摘 | Gull S F Skilling J | 1984 | Communications Radar and Signal Processing IEE Proceedings F1984，131，6： | 1 |
| 16 | Increases in renal epsilon-(gamma-glutamyl)-lysine crosslinks result from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy: pathologic implications 显示文摘 | Skill NJ Griffin M El Nahas AM | 2001 | Lab Invest2001，81，5： | 1 |
| 17 | Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure显示文摘AIM: Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and morbidity.Previous reports have suggested that the compound thalidomide attenuates portal hypertension(PHT).However, the mechanism for this action is not fully elucidated.One hypothesis is that thalidomide destabilizes tumor necrosis factor α(TNFα) mR NA and therefore diminishes TNFα induction of nitric oxide synthase(NOS) and the production of nitric oxide(NO).To examine this hypothesis, we utilized the murine partial portal vein ligation(PVL) PHT model in combination with endothelial or inducible NOS isoform gene knockout mice.METHODS: Wild type, inducible nitric oxide synthase(i NOS)-/- and endothelial nitric oxide synthase(e NOS)-/-mice received either PVL or sham surgery and were given either thalidomide or vehicle.Serum nitrate(total nitrate, NOx) was measured daily for 7 d as a surrogate of NO synthesis.Serum TNFα level was quantified by enzyme-linked immunosorbent assay.TNFα m RNA was quantified in liver and aorta tissue by reverse transcription-polymerase chain reaction.PHT was determined by recording splenic pulp pressure(SPP) and abdominal aortic flow after 0-7 d.Response to thalidomide was determined by measurement of SPP and mean arterial pressure(MAP).RESULTS: SPP, abdominal aortic flow(Qao) and plasma NOx were increased in wild type and i NOS-/-PVL mice when compared to sham operated control mice.In contrast, SPP, Qao and plasma NOx were not increased in e NOS-/- PVL mice when compared to sham controls.Serum TNFα level in both sham and PVL mice was below the detection limit of the commercial ELISA used.Therefore, the effect of thalidomide on serum TNFα levels was undetermined in wild type, e NOS-/-or i NOS-/- mice.Thalidomide acutely increased plasma NOx in wild type and e NOS-/- mice but not i NOS-/-mice.Moreover, thalidomide temporarily(0-90 min) decreased mean arterial pressure, SPP and Qao in wild type, e NOS-/- and i NOS-/- PVL mice, after which time levels returned to the respective baseline.CONCLUSION: Thalidomide does not reduce portalpressure in the murine PVL model by modulation of NO biosynthesis.Rather, thalidomide reduces PHT by decreasing MAP by an undetermined mechanism. | Nicholas G Theodorakis Yining N Wang Vyacheslav A Korshunov Mary A Maluccio Nicholas J Skill | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 18 | Maximum entropy image reconstruction: general algorithm显示文摘 | Skilling J Bryan R K | 1984 | Mon Not R astr Soc1984，211，1： | 1 |
| 19 | Increases in renal ε-(g-glutamyl)-lysine crosslinks result from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy:pathologic implications显示文摘 | Skill NJ Griffin M ElNahas AM | 2001 | Laboratory Investigation2001，81，： | 1 |
| 20 | Elevated epsilon-(gamma-glutamyl) lysine in human diabetic nephropathy results from increased expression and cellular release of tissue transglutaminase显示文摘 | EINahas AM Abo-Zenah H Skill NJ | 2004 | Nephron Clin Pract2004，97，： | 1 |
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