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| 1 | Thermogenic protein UCP1 and UCP3 expression in non- small cell lung cancer: relation with glycolysis and anaerobic metabolism显示文摘Uncoupling protein 1(UCP1)is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production.Using immunohistochemistry,we investigated the expression of UCP1 and UCP3 in a series of 98 patients with non-small cell lung cancer(NSCLC)treated with surgery.Expression patterns were correlated with histopathological variables,prognosis,and the expression of enzymes/proteins related to cell metabolism.Bronchial epithelium did not express UCP1 or UCP3,while alveolar cells strongly expressed UCP1.In tumors,strong expression of UCP1 and UCP3 was recorded in43/98(43.8%)and 27/98(27.6%)cases,respectively.UCP1 was significantly associated with squamous cell histology(P=0.05),whilst UCP3 was more frequently overexpressed in large cell carcinomas(P=0.08),and was inversely related to necrosis(P=0.009).In linear regression analysis,UCP1 was directly related to markers of glycolysis[hexokinase(HXKII)and phosphofructokinase(PFK1)]and anaerobic glucose metabolism[pyruvate dehydrogenase kinase(PDK1)and lactate dehydrogenase(LDH5)].UCP3 was directly linked with a glucose transporter(GLUT2),monocarboxylate transporter(MCT2),glycolysis markers(PFK1 and aldolase),and with the phosphorylation of pyruvate dehydrogenase(p PDH).Kaplan-Meier survival analysis showed that UCP3 was significantly related to poor prognosis in squamous cell carcinomas(P=0.04).UCP1 and UCP3 are overexpressed in a large subgroup of non-small cell lung tumors and their expression coincides with increased glucose absorption,intensified glycolysis,and anaerobic glucose usage.Whether UCPs are targets for therapeutic interventions in lung cancer is a hypothesis that demands further investigation. | Alexandra Giatromanolaki Konstantina Balaska Dimitra Kalamida Christos Kakouratos Efthimios Sivridis Michael I. Koukourakis | 2017 | Cancer Biology & Medicine2017，14，4： | 8 |
| 2 | Perifolliculitis capitis abscedens et suffodiens successfully controlled with topical isotretinoin显示文摘 | Karpouzis A Giatromanolaki A Sivridis E | 2003 | Eur J Dermatol2003，13，2： | 2 |
| 3 | Lac- tate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vas- cular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group 显示文摘 | Koukourakis MI Giatromanolaki A Sivridis E | 2006 | J Clin Oncol2006，24，26： | 1 |
| 4 | Hypoxia-inducible factor ( HIF1A and HIF2A), angiogenesis, and chemoradiotherapy out- come of squamous cell head-and-neck cancer显示文摘 | Koukourakis MI Giatromanolaki A Sivridis E | 2002 | Int J Radiat Oncol Biol Phys2002，53，5： | 1 |
| 5 | Endometrial carcinoma: association of steroid hormone receptor expression with low angiogenesis and bcl-2 expression显示文摘 | Efthimios Sivridis Alexandra Giatromanolaki Michael Koukourakis Panagiotis Anastasiadis | 2001 | Virchows Archiv2001，，5： | 1 |
| 6 | Upregulated hypoxia inducible factor-lalpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis显示文摘 | Giatromanolaki A Sivridis E Maltezos E | 2003 | Arthritis Res Ther2003，5，4： | 1 |
| 7 | Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angio- genic/molecular profile of tumours and survival 显示文摘 | Giatromanolaki A Koukourakis MI Sivridis E | 2001 | Br J Cancer2001，85，6： | 1 |
| 8 | Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma 显示文摘 | Koukourakis M I Giatromanolaki A Sivridis E | 2005 | Neoplasia2005，7，1： | 1 |
| 9 | Asso- ciation of hypoxia-inducible factors lalpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma 显示文摘 | Sivridis E Giatromanolaki A Gatter K C | 2002 | Cancer2002，95，5： | 1 |
| 10 | The angiogenic 'vascular endothelial growth factor/flk-1 (KDR)receptor'pathway in patients with endometrial carcinoma 显示文摘 | Sivridis E Brekken R | 2001 | Cancer2001，92，10： | 1 |
| 11 | Lactate de- hydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF,/VEGFR2 (KDR) pathway and prognosis显示文摘 | Giatromanolaki A Sivridis E Gatter KC | 2006 | Gynecol Oncol2006，103，3： | 1 |
| 12 | Angiogenesis in colorectal cancer: prognostic and therapeutic implications 显示文摘 | Giatromanolaki A Sivridis E Koukourakis MI | 2006 | Am J Clin Oncol2006，29，4： | 1 |
| 13 | LYVE-1 immunohistochemical assessment of lymphangiogenesis in endome- trial and lung cancer显示文摘 | Koukourakis M I Giatromanolaki A Sivridis E | 2005 | J Clin Pathol2005，58，2： | 1 |
| 14 | Angiogenic Factor Expression in Hepatic Cirrhosis显示文摘 | Alexandra Giatromanolaki Stamatia Kotsiou Michael I. Koukourakis Efthimios Sivridis | 2007 | Mediators of Inflammation2007，，： | 1 |
| 15 | LYVE-1 immunohistochemical assessment of lymphangiogenesis in endometrial and lung cancer显示文摘 | Koukourakis MI Giatromanolaki A Sivridis E | 2005 | J Clin Pathol2005，58，： | 1 |
| 16 | Hypoxia-inducible factor(HIF1A and HIF2A),angiogenesis,and chemoradiotherapy outcome of squamous cell head and neck cancer显示文摘 | Koukourakis MI Giatromanolaki A Sivridis E | 2002 | Int J Radiat Oncol Biol Phys2002，53，5： | 1 |
| 17 | Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas显示文摘 | Giatromanolaki A Sivridis E Simopoulos C | 2006 | J Surg Oncol2006，94，3： | 1 |
| 18 | Hypoxia-regula- ted carbonic anhydrase-9 ( CA9 ) relates to poor vascularization and re- sistance of squamous cell head and neck cancer to chemoradiotherapy 显示文摘 | Koukourakis MI Giatromanolaki A Sivridis E | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 19 | Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival显示文摘 | Giatromanolaki A Koukourakis MI Sivridis E | 2001 | Br J Cancer2001，85，6： | 1 |
| 20 | Loss of expres- sion and nuclear/cytoplasmic localization of the FOXP1 forkhead tra- nscription factor are common events in early endometrial cancer: rel-ationship with estrogen receptors and HIF-1 ct expression 显示文摘 | Giatromanolaki A Koukourakis MI Sivridis E | 2005 | Modem Pathol2005，19，1： | 1 |
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