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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Radical resection of focal brainstem gliomas: is it worth doing?显示文摘Childs Nerv Syst. 2008 Jun 18.OBJECTIVES: Despite revolutionary technical advancement in neuroimaging and operative neurosurgery, surgical extirpationof focal brainstem glioma (BSG) remains steeped in controversy. In this study, we evaluated our senior author' s (CT) | Teo C Siu TL | 2008 | 中国神经肿瘤杂志2008，6，2： | 2 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | The relative contribution of Chkl and Chk2 to Adriamycin induced checkpoint 显示文摘 | HO C C SIU W Y CHOW J P | 2005 | Exp Cell Res2005，304，1： | 1 |
| 5 | Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promyelocytic leukemia: implications for long-term cardiac safety 显示文摘 | J Siu CW Au WY Yung C | 2006 | Blood2006，108，1： | 1 |
| 6 | An effective Low Bit-Rate Video Coding Algorithm Focusing on Moving regions 显示文摘 | Wong K W Lam K M Siu W C | 2001 | IEEE Trans circuits and systems for video technology2001，11，10： | 1 |
| 7 | Recursive algorithm for the discrete cosine transform with general lengths 显示文摘 | Chau L P Siu W C | 1994 | Electronics Letters1994，30，： | 1 |
| 8 | Dynamic Event Trees in Accident Sequence Analysis : Application to Steam Generator Tube Rupture显示文摘 | Acosta C Siu N | 1993 | Reliability Engineering and System Safety1993，41，2： | 1 |
| 9 | Risk and predictors forpregnancy-related complications in women with heart disease 显示文摘 | Siu S C Sermer M Harrison D A | 1997 | Circulation1997，96，9： | 1 |
| 10 | Virulence and plasmid transferability of KPC Klebsiella pneumoniae at the veterans affairs healthcare system of new Jersey显示文摘 | Siu L K Lin J C Gomez E | 2012 | Microb Drug Resist2012，18，4： | 1 |
| 11 | Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5显示文摘 | Siu E C Wildenauer D B Tyndale R F | 2006 | Psychopharmacology (Berl)2006，，184： | 1 |
| 12 | Efficient recursive algorithm for the inverse discrete cosine transform 显示文摘 | Chau L P Siu W C | 2000 | IEEE Signal Processing Letters2000，7，： | 1 |
| 13 | Role of NCAM,cadherins,and microfilaments in cell-cell contact formation in TM4 immature mouse sertoli cells显示文摘 | SANDIG M KALNINS V I SIU C H | 1997 | Cell Motil Cytoskeleton1997，36，2： | 1 |
| 14 | New-onset heart failure after permanent right ventricular apical in patients with acquired high-grade atrioventricular block and normal left ventricular function 显示文摘 | ZHANG X H CHEN H SIU C W | 2008 | J Cardiovasc Electrophysiol2008，19，20： | 1 |
| 15 | Line - heat - source guarded - hot - plate apparatus 显示文摘 | Siu M C I Bulik C | 1981 | Review of Scientific Instruments1981，52，11： | 1 |
| 16 | Prevention of atrial fibrillation recurrence by statin therapy in patients with lone atrial fibrillation after successful cardioversion显示文摘 | Siu C W Lau C P Tse H F | 2003 | Am J Cardiol2003，92，11： | 1 |
| 17 | Adaptive dual-point Hough transform for object recognition显示文摘 | Chau C P Siu W C | 2004 | Computer Vision and Image Understanding2004，96，1： | 1 |
| 18 | DNA binding and cyto- toxicity of ruthenium(II) and rhenium(I) complexes of 2 -Amino-4-phenylamino-6- (2-pyridyl) - 1,3,5 -triazine 显示文摘 | Ma D L Che C M Siu F M | 2007 | Inorg Chem2007，46，： | 1 |
| 19 | Molecular properties and antioxidant activities of polysaccharide-protein complexes from selected mushrooms by ultrasound-assisted extraction 显示文摘 | Cheung Y C Siu K C Liu Y S | 2012 | Process Biochemistry2012，47，5： | 1 |
| 20 | Upgrading pacemaker patients with right ventricular apical pacing to right ventricular septal pacing improves left ventricular performance and functional capacity显示文摘 | TSE H F WONG K K SIU C W | 2009 | J Cardiovasc Electrophysiol2009，20，： | 1 |
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