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45篇 您的检索式:作者名="Sippl"
    题名 作者 年代 出处 被引量
1Making the Most of Time and Talent Secondary School Organizational Climates, Teaching Task Environments, and Teacher Commitment显示文摘Riehl C Sipple J W 1996American Educational Research Journal1996,,33:1
2Phase Ⅱ trial of weekly docetaxel/irinotecan combination in advanced pancreatic cancer显示文摘Burtness B Thomas L Sipples R 2007Cancer J2007,13,4:1
3Common side effects of anti-EGFR tberapy:aene- form rash显示文摘Sipples R 2006Semin Oncol Nurs2006,22,11:1
4Salidroside stimulatesDNA repair enzyme Parp -1 activity in mouse HSC main-tenance 显示文摘LI X SIPPLE J PANG QS 2012Blood2012,119,:1
5Overexpression of IL -3 Rot on CD34 + CD38 - stem cells defines leukemia - in-itiating cells in Fanconi anemia AML显示文摘DU W LI X SIPPLE J 2011Blood2011,117,:1
6Binding affinity prediction of novel estrogen receptor ligands using receptor-based 3-D QSAR methods显示文摘Sippl W 0,,:1
7Common side effects of anti-EGFR therapy:acneform rash显示文摘Sipples R 2006Semin Oncol Nurs2006,22,11:1
8Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyhransferase potencies and histamine hH3 receptor affinities显示文摘Grassmann S Apeh J Sippl W 2003Bioorg Med Chem2003,11,10:1
9Knowledge based potentials for proteins显示文摘 1995Curr Opin Struc Biol1995,5,:1
10Design, synthesis, and structure-activity relationships of a series of 3-pyridazine derivatives as acetylcholinesterase inhibitors 显示文摘Contreras JM Parrot I Sippl W 2001J Med Chem2001,44,:1
11Phase Ⅱ trial of weekly docetaxel/irinotecan combination in advanced pancreatic cancer显示文摘Burmess B Thomas L Sipples R 2007Cancer J2007,13,4:1
12Recognition of Errors in Three-Dimensional Structures of Proteins显示文摘Sippl M J 1993Proteins1993,17,4:1
13Palliative thyroidectomy for malignant lymphoma of the thyroid显示文摘Sipple RS Ganger PG Angelos P 2002Am Surg Oncol2002,9,9:1
14NAD(+) -de- pendent histone deacetylases (sirtuins) as novel therapeutic tar- gets显示文摘Sehemies J Ueieehowska U Sippl W 2010Med Res Rev2010,30,6:1
15Overexpression of IL-3Rct on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML显示文摘Du W Li XE Sipple J 2011Blood2011,117,16:1
16Knowledge Based Potentials for Proteins 显示文摘Sipple M J 1995Curr Opin Struc Biol1995,5,:1
17Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases:Schistosomiasis,Trypanosomiasis and Leishmaniasis显示文摘Parasitic diseases continue to represent a threat on a global scale,particularly among the poorest countries in the world.This is particularly because of the absence of vaccines,and in some cases,resistance against available drugs,currently being used for their treatment.In this review emphasis is laid on natural products and scaffolds from African medicinal plants(AMPs)for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases.In the discussion,emphasis has been laid on alkaloids,terpenoids,quinones,flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma,Trypanosoma and Leishmania species.In each subparagraph,emphasis is laid on the compound subclasses with most promising in vitro and/or in vivo activities of plant extracts and isolated compounds.Suggestions for future drug development from African medicinal plants have also been provided.This review covering 167 references,including 82 compounds,provides information published within two decades(1997-2017).Conrad V.Simoben Fidele Ntie-Kang Sergi H.Akone Wolfgang Sippl 2018Natural Products and Bioprospecting2018,8,3:1
18Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme显示文摘Céline Reverdy Susan Conrath Roman Lopez Cécile Planquette Cédric Atmanene Vincent Collura Jane Harpon Véronique Battaglia Valérie Vivat Wolfgang Sippl Frédéric Colland 2012Chemistry & Biology2012,,4:1
19Binding affinity prediction of novel estrogen receptor ligands using receptor-based 3-D QSAR methods显示文摘Sippl W 2002Bioor-ganic&Medicinal Chemistry2002,10,:1
20Deep burial of Asian continen- tal crust beneath the Pamir imaged with local earthquake tomo- graphy 显示文摘Sippl C Schurr B Tympel J 2013Earth and Planetary Science Letters2013,384,:1
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