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| 1 | 涎腺类乳腺分泌性癌:对25例标准RT-PCR法未能检出ETV6-NTRK3融合基因病例的进一步分子分析:4例存在ETV6-X融合基因显示文摘ETV6基因异常在肿瘤病理学已有完整描述,据文献报道不同的上皮性肿瘤和血液系统恶性肿瘤可检出多种ETV6融合基因伴侣。在涎腺肿瘤病理中,ETV6-NTRK3易位被认为是乳腺分泌性癌的特异性改变,而在其他类型的涎腺肿瘤中均木见报道。 | Skálová A Vanecek T Simpson R H 胡舜 余英豪 | 2016 | 临床与实验病理学杂志2016，32，5： | 21 |
| 2 | 涎腺类乳腺分泌性癌:采用标准RT-PCR法未能检出25例ETV6-NTRK3融合基因的进一步分子分型(4例存在ETV6-X融合基因)显示文摘ETV6基因异常在肿瘤病理学中已有完整描述。据文献报道,不同的上皮性肿瘤和血液系统恶性肿瘤可检出多种ETV6融合基因伴侣。在涎腺肿瘤病理中,ETV6-NTRK3易位被认为是类乳腺分泌性癌(MASC)的特异性改变,而在其他类型的涎腺肿瘤中均未见报道。 | Skálová A Vanecek T Simpson R H 胡舜 余英豪 | 2016 | 临床与实验病理学杂志2016，32，3： | 13 |
| 3 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 4 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 5 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 6 | Role model analysis of an asynchronous communication mechanism显示文摘 | Simpson H R | 1997 | IEEE Proceedings Computers & Digital Techniques1997，144，4： | 1 |
| 7 | Satellite detection of natural hydrocarbon seepage: Palm Valley gas field, Amadeus Basin, Central Australia显示文摘 | Simpson C J Wilford J R Macials L F | 1989 | The APEA Journal1989，29，： | 1 |
| 8 | Developments in unsteady pipe flow friction modeling 显示文摘 | BERGANT A SIMPSON A R VITKOVSKY J P | 2001 | J Hydraul Res2001，39，3： | 1 |
| 9 | 17a-hydroxylase/17,20-1yase deficiency: from clinical investigation to molecular definition显示文摘 | YANASE T SIMPSON E R WATERMAN M R | 1991 | Endocr Rew1991，12，： | 1 |
| 10 | Genetic algorithms for reliability-based optimization of water distribution systems显示文摘 | Bryan A Tolson Holger R Maierl Angus R Simpson | 2005 | Journal of Water Resources and Management2005，26，6： | 1 |
| 11 | Leak detection and calibration using transients and genetic algorithms显示文摘 | Vitkovsky J P Simpson A R Martin F L | 2000 | Journal Water Resource Planning and Management2000，126，4： | 1 |
| 12 | Factors affecting shoot development in apically dominant Acer cultivars in vitro显示文摘 | Marks T R Simpson S E | 1994 | Journal of Horticultural Science1994，69，3： | 1 |
| 13 | Aromatase eytochrome 17450, the enzyme resporsible for estrogen biosynthesis 显示文摘 | Simpson E R Mahendroo M S Means G D | 1994 | Endocrinol Rev1994，15，： | 1 |
| 14 | Product platform design: Method and application 显示文摘 | Simpson T W Maier J R A Mistree F | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 15 | A Procedure for the Detection and Removal of Cloud Shadow from AVHRR Data over Land显示文摘 | Simpson J J Stitt J R | 1998 | IEEE Transaction on Geoscience and Remote Sensing1998，36，3： | 1 |
| 16 | Cribriform adenocarcinoma of the tougue:a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tougue显示文摘 | Michal M Skalova A Simpson R H W | 1999 | Histopathology1999，35，6： | 1 |
| 17 | Junction flows显示文摘 | Simpson R L | 2001 | Annual Review of Fluid Mechanics2001，33，1： | 1 |
| 18 | Reynolds stress and TKE production in an estuary with a tidal bore显示文摘 | SIMPSON J H FISHER N R WILES P | 2004 | Estuarine Coastal and Shelf Science2004，60，4： | 1 |
| 19 | Si- nonasal renal cell-like adenocarcinoma: report on four patients显示文摘 | STORCK K HADI U M SIMPSON R | 2008 | Head NeckPathol2008，2，： | 1 |
| 20 | A proposed Tropical Rainfall Measuring Mission (TRMM) satellite显示文摘 | SIMPSON J ADLER R F NORTH G R | 1988 | Bull Amer Meteor Soc1988，69，3： | 1 |
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