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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis显示文摘AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODS Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western blotting.RESULTS Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein levels.CONCLUSION The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatment strategy. | Robert G Bennett Ronda L Simpson Frederick G Hamel | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 3 | The opera- tive treatment of scapular fracture 显示文摘 | Hardegger F H Simpson L A Weber B G | 1984 | J Bone joint Surg Br1984，66，： | 1 |
| 4 | The operative treatment of scapular fractures 显示文摘 | Hardegger F H Simpson L A Weber B G | 1984 | J Bone Joint Surg (Br)1984，66，7： | 1 |
| 5 | The operative treatment of scapular fracture显示文摘 | Hardegger F H Simpson L A Weber B G | | 0，，05： | 1 |
| 6 | The overlap syndrome of asthma and COPD:what are its features and how important is it显示文摘 | Gibson P G Simpson J L | 2009 | Thorax2009，64，： | 1 |
| 7 | Design of an oxygen concentrator using the rapid pressure swing adsorption principle显示文摘 | Pitchard C L Simpson G K | | 0，，： | 1 |
| 8 | Biomass and carbon storage of the North American deciduous forest显示文摘 | Botkin D B Simpson L G Nisbet R A | 1993 | Biogeochemistry1993，20，1： | 1 |
| 9 | The operative treatment of scapular fractures显示文摘 | HARDEGGER F H SIMPSON L A WEBER B G | 1984 | J Bone Joint Surg Br1984，66，： | 1 |
| 10 | The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis显示文摘 | Holt R I G Simpson H L Snksen P H | 2003 | Diabet Med2003，20，1： | 1 |
| 11 | Effect of short-term resuspension events on the oxidation of Cadmium, Lead, and Zinc sulfide phase in anoxic estuarine sediments显示文摘 | Simpson S L Apte S C Bately G E | 2000 | Environ Sci Technol2000，34，： | 1 |
| 12 | Hysterosalpingography:A Reemerging Study显示文摘 | William L Simpson Laura G B | 2006 | Education Exhibit2006，26，2： | 1 |
| 13 | The operative treatment of scapular fracture显示文摘 | Hardegger F H Simpson L A Weber B G | 1984 | J Bone Joint Surg1984，66，： | 1 |
| 14 | Steel cleanness requirements for X65 to X80 electric resistance welded linepipe steels显示文摘 | Simpson I D Tritsiniotis Z Moore L G | 2003 | Ironmaking and Steelmaking2003，30，2： | 1 |
| 15 | Variations in methane and nitrous oxide mixing ratios at the southern boundary of a Canadian boreal forest显示文摘 | Simpson L J Edwards G C Thurtell G W | 1999 | Atmospheric Environment1999，33，： | 1 |
| 16 | The operative treatment of scapular fractu re显示文摘 | Hardegger F H Simpson L A Weber B G | 1984 | Bon e Joint Surg(Br)1984，66，5： | 1 |
| 17 | A review of existing and proposed new leaf nutrient standardsfor lychee显示文摘 | MENZEL C M CARSELDINE M L HAYDON G F SIMPSON DR | 1992 | Scientia Horticulture1992，49，： | 1 |
| 18 | The operative treatment of scapula fraetrures 显示文摘 | Hardeggr F H Simpson L A Weber B G | 1984 | J Bone Join t Surg(Br )1984，66，5： | 1 |
| 19 | An inves- tigation of road crossing in a virtual environment显示文摘 | Simpson G Johnston L Richardson M | 2003 | Accident Analysis and Prevention2003，35，5： | 1 |
| 20 | A CMOS variable amplifier for PHENIX electromagnetic calorimeter and RICH energy measurements显示文摘 | Wintenberg A L Simpson M L Young G R | 1997 | IEEE Trans Nucl Sci1997，44，3： | 1 |
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