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| 1 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 2 | Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the'multiple parallel hits'theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. | Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 3 | Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes显示文摘The hepatitis C virus(HCV) is one of the most common causes of chronic liver disease and the leading indication for liver transplantation worldwide. Every aspect of the HCV life cycle is closely tied to human lipid metabolism. The virus circulates as a lipid-rich particle, utilizing lipoprotein cell receptors to gain entry into the hepatocyte. It has also been shown to upregulate lipid biosynthesis and impair lipid degradation, resulting in significant intracellular lipid accumulation and circulating hypocholesterolemia. Patients with chronic hepatitis C(CHC) are at increased risk of hepatic steatosis, fibrosis, and cardiovascular disease including accelerated atherosclerosis. HMG Co A Reductase inhibitors, or statins, have been shown to play an important role in the modulation of hepatic steatosis and fibrosis, and recent attention has focused upon their potential therapeutic role in CHC. This article reviews the hepatitis C viral life cycle as it impacts host lipoproteins and lipid metabolism. It then describes the pathogenesis of HCV-related hepatic steatosis, hypocholesterolemia and atherosclerosis, and finally describes the promising anti-viral and anti-fibrotic effects of statins, for the treatment of CHC. | Tracey G Simon Adeel A Butt | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 4 | Cardiac valve endothelial cells: relevance in the long-term function of biologic valve prostheses 显示文摘 | Simon A wilhelmi M steinhoff G | 1998 | J Thorac Cardiovasc Surg1998，116，3： | 2 |
| 5 | TNFalpha and its receptors in psoriatic skin,before and after treatment with etanercept显示文摘 | Caldarola G De Simone C Carbone A Tulli A Amerio P Feliciani C | 2009 | Int J Immunopathol Pharmacol2009，22，4： | 1 |
| 6 | Effects of age, gender and race/ethnicity on the pharmacokinetics of posaconazole in healthy volunteers 显示文摘 | Sansone- Parsons A Krishna G Simon J | 2007 | Antimicrob Agents Chemother2007，51，2： | 1 |
| 7 | Short overview of bird control in sweet and sour cherry or- chards - Possibilities of protection of bird damage and its effectiveness 显示文摘 | Simon G A | 2008 | International Journal of Horticultural Science2008，14，12： | 1 |
| 8 | 查看详情显示文摘 | Simon T Kroger A Somsen C Dlouhy A Eggeler G | | 0，，： | 1 |
| 9 | Impacts of land use conflicts on riverine ecosystems 显示文摘 | Renato F Valle Junior Simone G P Varandas Femando A L Pacheco | 2014 | Land Use Policy2014，43，： | 1 |
| 10 | Feasibility and efficacy of molecular analysis- directed individualized therapy in advanced non - small - cell lung cancer显示文摘 | Simon G Sharma A Li X | 2007 | J Clin Oncol2007，25，19： | 1 |
| 11 | Symmetry-based re- sistance as a novel means of lower limb rehabilitation 显示文摘 | Simon A M Brent G R Ferris D P | 2007 | Journal of Biomechanics2007，40，6： | 1 |
| 12 | Intima-media thickness:a new tool for diagnosis and treatment of cardiovascular risk显示文摘 | Simon A Gariepy J Chironi G | | J Hyp0，，： | 1 |
| 13 | Photodynamic therapy and the immune system in experimental oncology显示文摘 | Canti G De Simone A Korbelik M | 2002 | Photochem Photobiol Sci2002，1，： | 1 |
| 14 | Lensed fiber-array assembly with individu- al fiber fine positioning in the submicrometer range 显示文摘 | Johan H C van Zantvoort Simon G L Plukker Erwin C A Dekkers | 2006 | IEEE Selected Topics in Quantum Electronics2006，12，05： | 1 |
| 15 | Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects 显示文摘 | Chironi G Simon A Hugel B | 2006 | Arterioscler Thromb Vascular Biol2006，26，12： | 1 |
| 16 | Characterization of as- phaltenes and resins from problematic Mexican crude oils 显示文摘 | Eduardo B G Marcela E P Simon I A | 2001 | Petro- leum Sci Technol2001，19，34： | 1 |
| 17 | Estrogen and progestin,lipoprotein(a),and the risk of recurrent coronary heart disease events after menopause显示文摘 | SHLIPAK M G SIMON J A VITTINGHOFF E | 2000 | JAMA2000，283，14： | 1 |
| 18 | Comparative performance of subclinical atherosclerosis tests in predicting coronary heart disease in asymptomatic individuals显示文摘 | Simon A Chironi G Levenson J | 2007 | Eur Heart J2007，28，24： | 1 |
| 19 | Image Fusion Techniques for Remote Sensing Applications显示文摘 | G Simone A Farina | 2002 | Information Fusion2002，3，： | 1 |
| 20 | Hypersurfaces with prescribed affine Gauss-Kronecker curvature显示文摘 | Li A M Simon U Zhao G S | 2000 | Geometriae Dedicata2000，81，： | 1 |
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