|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 3 | Synthesis of CMP-NeuAc from N-acetylglucosamine: Generation of CTP from CMP using adenylate kinase 显示文摘 | Simon E S Bednarski M D Whitesides G M | 1988 | J Am Chem Soc1988，110，： | 2 |
| 4 | Themomechanical properties and morphology of blends of a hydroxyl-functionalized hyperbranched polymer and epoxy resin显示文摘 | RATNA D SIMON G P | 2001 | Polymer2001，42，21： | 1 |
| 5 | Antibiotic selection for patients with septic shock显示文摘 | Trenhoime G | 2000 | Crit Care Clin2000，16，2： | 1 |
| 6 | Mayo clinic Scottsdale experience with laparoscopic nephron sparing surgery for renal tumors 显示文摘 | Simon S D Ferrigni R G Novicki D E | 2003 | J Urol2003，169，6： | 1 |
| 7 | Carrying capacity in the tourism industry: a case study of Hengistbury Head显示文摘 | Simon F J G Narangajavana Y Marquis D P | 2004 | Tourism Manage- ment2004，25，： | 1 |
| 8 | Symmetry-based re- sistance as a novel means of lower limb rehabilitation 显示文摘 | Simon A M Brent G R Ferris D P | 2007 | Journal of Biomechanics2007，40，6： | 1 |
| 9 | Impact of left ventricular geometry on prognosis in hypertensive patients with left ventricular hypertrophy (the LIFE study)显示文摘 | GERDTS E CRAMARIUC D DE SIMONE G | 2008 | Eur J Echocardiogr2008，9，： | 1 |
| 10 | Characterization of 14 microsatellite markers for genetic analysis and cultivar identification of walnut显示文摘 | Dangl GS Woeste K Aradhya MK Koehmstedt A simon C Potter D Leslie CA.McGranahan G | | 0，，： | 1 |
| 11 | The Proinfammatory actions of Angiotensin Ⅱ are Dependent on p65 phosphorylation by the 1κB kinase complex显示文摘 | Annie D Annie BP Simon G | 2006 | J Biol Chem2006，281，13： | 1 |
| 12 | Generation of cytidine 5'-triphosphate using adenylatekinase显示文摘 | SIMON E S BEDNARSKI M D WHITESIDES G M | 1988 | Tetrahedron Letters1988，29，10： | 1 |
| 13 | Fulvcstrant ('Faslodex'):clinical experience from the Compassionate Use Programme显示文摘 | STEGER G G GIPS M SIMON S D | | 0，，2： | 1 |
| 14 | New assessment of endothelium-depent flow-mediated vasodilation to characterize endothelium dysfunction显示文摘 | Craiem D Chironi G Simon A | 2008 | Am J Ther2008，15，4： | 1 |
| 15 | Microlens arrays on large area UV transparent hybrid sol-gel materials for ooticaltools 显示文摘 | SIMONE D Z GIOIA D G GIOVANNA B | 2010 | Microelectron|c Engineering(S0167-9317)2010，87，58： | 1 |
| 16 | Fluid dynamics of cricket ball swing 显示文摘 | SCOBIE JAMES A PICKERING SIMON G ALMOND DARRYL P LOCK GARY D | 2013 | Proceedings of the Institution of Mechanical Engineers Part P: Journal of Sports Engineering and Technology2013，227，3： | 1 |
| 17 | Strong and bioactive composites containing nano-silica-fused whiskers for bone repair显示文摘 | XU H H SMITH D T SIMON C G | 2004 | Biomaterials2004，25，19： | 1 |
| 18 | Car- rying capacity in the tourism industry= A case study of Hengistbury Head显示文摘 | SIMON F G NARANGAJAVANA Y MARQUES D P | 2004 | Tourism Management2004，25，2： | 1 |
| 19 | Crystal structure of sandaracopimaric acid,a lipoxygenase inhibitor from Junzperus phoenzcea显示文摘 | COMTE G ALLAIS D P SIMON A | 1995 | Journal of Natural Products1995，58，2： | 1 |
| 20 | Managing Resources:Linking Unique Resources,Management and Wealth Creation in Family Firms显示文摘 | SIMON D G HITT M A IRELAND R D | 2003 | Entrepreneurship Theory and Practice2003，27，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员