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| 1 | Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients显示文摘AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation. | A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E Roda D Festi | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 2 | Increased oxidativestress following acute and chronic high altitude exposure显示文摘 | Jefferson JA Simoni J Elizabeth E | 2004 | High altitude medicine&biology2004，5，1： | 1 |
| 3 | EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions 显示文摘 | Simoni M Bakker E Krausz C | 2004 | Int J Androl2004，27，4： | 1 |
| 4 | Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip(4C)显示文摘 | Simonis M Klous P Splinter E | 2006 | Nat Genet2006，38，11： | 1 |
| 5 | Inhibin B in male reproduction:pathophysiology and clinical relevance显示文摘 | Meachem SJ Nieschlag E Simoni M | | 0，，05： | 1 |
| 6 | EAA/EMQN best pracTICe guidelines for molecular diagnosis of Y chromosomal microdeletions 显示文摘 | Simoni M Bakker E Krausz C | 2004 | lnt J An drol2004，27，4： | 1 |
| 7 | Sorption of Uranium(VI)onto Lanthanum Phosphate Surfaces显示文摘 | Ordoez-Regil E Drot R Simoni E | 2002 | Langmuir2002，18，： | 1 |
| 8 | The follicle-stimulating hormone receptor:biochemistry,molecular biology,physiology,and pathophysiology显示文摘 | Simoni M Gromoll J Nieschlag E | 1997 | Endocrinol Rev1997，18，6： | 1 |
| 9 | Laboratory guidelines for molecular diagnosis of Y-chromosomal microdeletions 显示文摘 | Simoni M Bakker E Eurlings MC | 1999 | IntJ Androl1999，22，5： | 1 |
| 10 | Laboratory guidelines for molecular diagnosis of Y-chromosomal microdeletions显示文摘 | Simoni M Bakker E Eurlings MC | 1999 | Int J Androl1999，22，5： | 1 |
| 11 | EAA/EMQN best practice guidelines for molecular diagnosis of y-chromosomal microdeletious显示文摘 | Bakker E Krausz C | 2004 | Int J Androl2004，27，4： | 1 |
| 12 | EAA/EMQN best practice guidelines for molecular diagnosis of y-chromosomal mierodeletions State of the art 2004显示文摘 | Simoni M Bakker E Krausz C | 2004 | Int J Androl2004，27，4： | 1 |
| 13 | Synthesis and bio- logical evaluation of novel allophenylnorstatine-based HIV-1 pro- tease inhibitors incorporating high affinity P2-1igands显示文摘 | GHOSH AK GEMMA S SIMONI E | 2010 | Bioorg Med Chem Lett2010，20，3： | 1 |
| 14 | Inhibin B in male reproduction:pathophysiology and clinical relevance显示文摘 | Meachem SJ Nieschlag E Simoni M | 2001 | Eur J Endorinol2001，145，5： | 1 |
| 15 | Uranium(Ⅵ)Interaction With Pyrite(FeS2):Chemical and Spectroscopic Studies显示文摘 | Eglizaud N Miserque F Simoni E | 2006 | Radiochim Acta2006，94，911： | 1 |
| 16 | Transient hyperphosphatasemia of infancy and childhood:a study of serum alkaline phosphatase by electrofocusing techniques显示文摘 | Griffiths J Vernocchi A Simoni E | 1995 | Arch Pathol Lab Med1995，119，9： | 1 |
| 17 | Laboratory guidelines for molecular diagnosis of Y-chromosomal microdeletions 显示文摘 | Simoni M Bakker E Eurlings MC | 1999 | Int J Androl1999，22，5： | 1 |
| 18 | Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer′s disease 显示文摘 | Simoni E Daniele S Bottegoni G | 2012 | J Med Chem2012，55，22： | 1 |
| 19 | Current status of the mokecular diagnosis of Y-chromosomal microdeletions in the Work-up of male infertility显示文摘 | Simoni M Kamischke A Nieschlag E | 1998 | Hum Reprod1998，13，7： | 1 |
| 20 | Investigation of charge transfer O^2-→Ln^3+ and F^-→Ln^3+ in LnF3 :(Ln^3+, O^2- ) and YF3 : (Ln^3+, O^2- ) systems显示文摘 | Gerard I Krupa J C Simoni E | 1994 | J of Alloys and Comp1994，207，： | 1 |
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