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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 3 | The impact of family history of hepatocellular carcinoma on its patients' survival显示文摘BACKGROUND:Family history of hepatocellular carcinoma(HCC) has been identified as a risk factor for the development of the disease.The aim of this study is to evaluate the impact of such a history on HCC patients' survival.METHODS:Data of all HCC patients(n=4532) managed at our center from 1989 to 2008 were prospectively collected.The patients were quizzed on their various characteristics including family HCC history.RESULTS:Totally 475(10.48%) patients had a family history of HCC.They presented the disease at a significantly earlier age(median 53 vs 59 years,P<0.0001) and at an earlier stage(the United Network for Organ Sharing staging system).They had significantly better liver function in terms of ChildPugh classification and serum albumin and bilirubin levels.Significantly more of them presented the disease without symptoms(44.0% vs 29.4%,P<0.0001).They also had significantly better overall survival under these specifications:patients in the whole study cohort,patients who had minor hepatectomy,patients with stage I disease,patients with stage II disease,and patients with stage III disease.CONCLUSIONS:Contrary to what is generally believed,we found in this study cohort that patients with a family history of HCC had better overall survival than those without such a history.We believe this was in part due to earlier diagnosis of the disease and better liver function in this group of patients.However,the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified. | Wing Chiu Dai Sheung Tat Fan Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Ronnie TP Poon Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 2 |
| 4 | Identification of two flavivirus-like genomes in the GB hepatitis agent显示文摘 | Simons JN Pilot-Matias TJ Leary TP | 1995 | Proc Natl Acad Sci1995，92，8： | 1 |
| 5 | Isolation of novel virus - like sequences associated with human hepatitis 显示文摘 | Simons JN Leary TP Dawsin GJ | 1995 | Nature Medicine1995，1，8： | 1 |
| 6 | Isolation of novel-like sequences associated with human hepatitis显示文摘 | SIMONS JN LEARY TP DAWSON GJ | 1995 | Nat Med1995，1，6： | 1 |
| 7 | Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study 显示文摘 | Simon TP Schuerholz T Huter L | 2012 | Crit Care2012，16，1： | 1 |
| 8 | Seqeene and genomic organization of GBV - C: a novel member of the flaviviridae associated with human non A--E hepatitis显示文摘 | Leary TP Muerhoff AS Simons JN | 1996 | J Med Virol1996，48，： | 1 |
| 9 | A national pro-pensity -adjusted analysis of adjuvant radiotherapy in thetreatment of resected pancreatic adenocarcinoma显示文摘 | McDADE TP HILL JS SIMONS JP | 2010 | Canc-er2010，116，13： | 1 |
| 10 | Sequence and genomic organization of GBV-C:a novel member of the Flaviviridae associated with human non-A-E hepatitis显示文摘 | Muerhoff AS Simons JN | 1996 | J Med Virol1996，48，： | 1 |
| 11 | Identification of two flavivrus-like genomes in the GB hepatitis agent显示文摘 | Simons JN Pilot-Matia TJ Leafy TP et 81 | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 12 | Seqences and genomic organization of GBV-C A novel member of the flaviviridne associated with humen non A-E hepititis显示文摘 | Lecrry TP Muerhoff AS Simons JN | 1996 | J Ned Virol1996，48，： | 1 |
| 13 | Molecular diagnostic assays for the detection of GB virus infection显示文摘 | Lecrry TP Mucrhoff AS Simons JN | 1996 | J Ned Virol1996，48，： | 1 |
| 14 | Isolation of novel virus-like sequences associated with human hepatitis显示文摘 | Simons JN Leary TP Dawson GJ | 1995 | Natl Med1995，1，： | 1 |
| 15 | Iso Lation of novel viruslike sequence associated with human hepatitis显示文摘 | Simons JN Leary TP Dawson GJ | 1995 | N at med1995，1，： | 1 |
| 16 | Sequence and genomic organization of GBV-C:a novel member of the flauividae associated with human non-A-E hepatitis显示文摘 | Leary TP Muerhoff AS Simons JN | 1996 | J Med Virol1996，48，： | 1 |
| 17 | Isolation of novel virus-like sequences associated with human hepatitis显示文摘 | Simons JN Leary TP Dawson GJ | 1995 | Nat Med1995，1，6： | 1 |
| 18 | Hydroxyethylstareh impairs renal function and induces interstitial proliferation,macrophage infiltration and tubular damage in an isolated renal perfusion model显示文摘 | Hüter L Simon TP Weinmann L | 2009 | Crit Care2009，13，： | 1 |
| 19 | Sequence and genomic organization of GBV-C: A novel member of the flaviviridae associated with human non-A-E hepatitis显示文摘 | LEARY TP MUERHOFF AS SIMONS JN | 1996 | J Med Virol1996，48，： | 1 |
| 20 | Sequence heterogenity whithin the 5′-teminal region of the hepatitis GB virus C genome and evidence for genotypes显示文摘 | MUERHOFF AS LEARY TP SIMONS JN | 1996 | J Hepatol1996，25，： | 1 |
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