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| 1 | Portal vein thrombosis in cirrhosis: Controversies and latest developments显示文摘Portal vein thrombosis(PVT) is encountered in livercirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication.We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation,and management. Studies were identified by a search strategy using MEDLINE and Google Scholar. The incidence of PVT increases with increasing severity of liver disease: less than 1% in well-compensated cirrhosis, 7.4%-16% in advanced cirrhosis. Prevalence in patients undergoing liver transplantation is 5%-16%.PVT frequently regresses instead of uniform thrombus progression. PVT is not associated with increased risk of mortality. Optimal management has not been addressed in any consensus publication. We propose areas for future research to address unresolved clinical questions. | Damian J Harding M Thamara PR Perera Frederick Chen Simon Olliff Dhiraj Tripathi | 2015 | World Journal of Gastroenterology2015，21，22： | 42 |
| 2 | Current status and recent advances of liver transplantation from donation after cardiac death显示文摘The last decade saw increased organ donation activity from donors after cardiac death (DCD). This contributed to a signif icant proportion of transplant activity. Despite certain drawbacks, liver transplantation from DCD donors continues to supplement the donor pool on the backdrop of a severe organ shortage. Understanding the pathophysiology has provided the basis for modulation of DCD organs that has been proven to be effective outside liver transplantation but remains experimental in liver transplantation models. Research continues on how best to further increase the utility of DCD grafts. Most of the work has been carried out exploring the use of organ preservation using machine assisted perfusion. Both ex-situ and in-situ organ perfusion systems are tested in the liver transplantation setting with promising results. Additional techniques involved pharmacological manipulation of the donor, graft and the recipient. Ethical barriers and end-of-life care pathways are obstacles to widespread clinical application of some of the recent advances to practice. It is likely that some of the DCD offers are in fact probably 'prematurely' of-fered without ideal donor management or even prior to brain death being established. The absolute benef its of DCD exist only if this form of donation supplements the existing deceased donor pool; hence, it is worthwhile revisiting organ donation process enabling us to identify counter remedial measures. | M Thamara PR Perera Simon R Bramhall | 2011 | World Journal of Gastrointestinal Surgery2011，3，11： | 16 |
| 3 | Estimating the Global Public Health Implications of Electricity and Coal Consumption显示文摘 | Gohlke Julia M Thomas Reuben Woodward Alistair Campbell-Lendrum Diarmid Prüss-üstün Annette Hales Simon Portier Christopher J | 2011 | Environmental Health Perspectives2011，，6： | 2 |
| 4 | Dentin-pulp complex regeneration: from lab to clinic显示文摘 | Simon SR Berdal A Cooper PR | 2011 | Adv Dent Res2011，23，3： | 1 |
| 5 | Nontuberculous mycobacteria in respiratory tract infections, eastern Asia 显示文摘 | SIMONS S VAN INGEN J HSUEH PR | 2011 | Emerg Infect Dis2011，17，3： | 1 |
| 6 | Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women显示文摘 | Silvia V Kevin C Simon PR | 2003 | British Journal of nutrition2003，89，1： | 1 |
| 7 | Nontuberculousmycobacteria in respiratory tract infections, eastern Asia显示文摘 | Simons S van Ingen J Hsueh PR | 2011 | Emerg Infect Dis2011，17，3： | 1 |
| 8 | Cross-specles compatibility of intercellular adhesion molecule-1(CD54) with its ligands显示文摘 | Warrens AN Simon AR Theodore PR | 2000 | Transplantation2000，69，3： | 1 |
| 9 | Dentin-pulp complex regeneration:from lab to clinic显示文摘 | Simon SR Berdal A Cooper PR | 2011 | Adv Dent Res2011，23，3： | 1 |
| 10 | Dentin -pulp complexregnerationrfrom lab to clinic显示文摘 | Simon SR Berdal A Cooper PR | 2011 | Adv Dent Res2011，23，3： | 1 |
| 11 | Enhancement of migration by protein kinase C alpha and inhibition of proliferation and cell cycle progression by protein kinase C delta in capillary endothelial cells显示文摘 | Harrington EO Loffler J Nelson PR Kent KC Simons M Ware JA | 1997 | J Biol Chem1997，272，： | 1 |
| 12 | Dentin-pulp complex regeneration: from lab to clinic显示文摘 | Simon SR Berdal A Cooper PR | 2011 | Adv Dent Res2011，23，3： | 1 |
| 13 | Nontuberculous mycobacteria in respiratory tract infections, eastern Asia显示文摘 | SIMONS S VAN INGEN J HSUEH PR | 2011 | Emerg Infecti Dis2011，17，3： | 1 |
| 14 | Soil fauna of a reclaimed lignite open-cast mine of the Rhineland: improvement of soil quality by surface pattern 显示文摘 | Topp W Simon M Kautz G Dworschak U Nicolini F Pr?ckner S | 2001 | Ecol Eng2001，17，： | 1 |
| 15 | Survival of cells afterintrlar tieu tartrans plant at ionof fresh all grafts of the Patell arandanterior crueiate ligaments显示文摘 | Jaekson DW Simon TM Kurzweil PR | 1992 | J Bone Joint Surg Am1992，74，1： | 1 |
| 16 | Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data显示文摘 | Gaedigk A Gotschall PR Forbes NS Simon SD Kearns GL Leeder JS | 1999 | Pharmacogenetics1999，9，： | 1 |
| 17 | Survival of cells after intra-articular transplantation of fresh allografts of the patellar and anterior cruciate ligaments显示文摘 | Jackson DW Simon TM Kurzweil PR | 1992 | J Bone Joint Surg [Am]1992，74，1： | 1 |
| 18 | Nontuberculous mycobacteria in respiratory tract infections,eastern Asia显示文摘 | Simons S van Ingen J Hsueh PR | | 0，，03： | 1 |
| 19 | Role of nitric oxide production in anaphylaxis and its relevance for the treatment of anaphylactic hypotension with methylene blue 显示文摘 | Evora PR Simon MR | 2007 | Ann Allergy Asthma Immunol2007，99，4： | 1 |
| 20 | Incidence of diabetes mellitus in a population-based cohort of persons with chronic hepatitis B virus infection显示文摘 | Spradling PR Simons B Narayanan M | 2013 | J Viral Hepat2013，20，7： | 1 |
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