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| 1 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 2 | A perturbed Lagrangian formulation for the finite element solution of contact problems显示文摘 | Wriggers P Taylor R L | 1985 | Comp Meth Appl Mech Engng1985，50，： | 1 |
| 3 | Capillary electrophoresis of methyl subsliluted phenol in acetonilrile 显示文摘 | Porras Simo P Kuldvce Ruth Palonen Sami | 2003 | Journal of Chromatography A2003，990，12： | 1 |
| 4 | A perturbed Lagrangian formulation for the finite element solution of contact problems显示文摘 | SIMO J C WRIGGER P TAYOR R L | 1985 | Computer Methods in Applied Mechanics and Engineering1985，50，16： | 1 |
| 5 | Analytical charac- terization of the passive film formed on steel in solutions simulat- ing the concrete interstitial electrolyte 显示文摘 | Montemor M F Simoes A M P Ferreira M G S | 1998 | Corrosion1998，54，： | 1 |
| 6 | 显示文摘 | Montemor M F Simoes A M P Ferreira M G S | 2005 | Cem Concr Compos2005，25，： | 1 |
| 7 | Serum concentrations of laminin-P1 in diabetes mellitus:usefulness as an index of diabetic microangiopathy 显示文摘 | Simo M L Masmiquel L Garcia P L | 1996 | Diabetes Res Clin Pract1996，32，： | 1 |
| 8 | 显示文摘 | Montemor M F Simoes A M P Ferreira M G S | 2003 | Cement & Concrete Composites2003，25，： | 1 |
| 9 | A high-torque low-speed multiphase brushless machine-a perspective application for electric vehicles显示文摘 | Simoes M G Vieira P Jr | 2002 | IEEE Trans on Industrial Electronics2002，49，5： | 1 |
| 10 | On the equivalence of estimations under a general linear model and its transformed models显示文摘 | Tian Y Simo P | | 0，，10： | 1 |
| 11 | Study of the topology and robust-ness of airline route networks from the complex network ap-proach: a survey and research agenda 显示文摘 | Lordan 0 Sallan J M Simo P | 2014 | Journal of TransportGeography2014，37，： | 1 |
| 12 | Effect of treadmill exercise on lumbar vertebrae in ovariectomized rats : anthropometrical and mechanical analyses显示文摘 | Simoes PA Zamarioli A Bloes P | 2008 | Acta Bioeng Biomech2008，10，2： | 1 |
| 13 | Experimental behaviour of end-plate beam-to-column composite joints under monotonical loading显示文摘 | Simoes da Silva L Simoes R D Cruz P J S | 2001 | Engineering Structures2001，23，： | 1 |
| 14 | Background levels of atmospheric hydrocarbons, sulphate and nitrate over the western mediterranean 显示文摘 | Simo R Grimalt J P Albaiges J 1997 | 1997 | Environ Sci Technol1997，31，： | 1 |
| 15 | Chloride-inducedCorrosion on Reinforcing Steel: from the Fundamentals to the Monitoring Techniques 显示文摘 | M F Montemor A M P Simoes M G S Ferreira | 2003 | Cement & Concrete Composites2003，25，： | 1 |
| 16 | Effect of treadmill exerciseon lumbar vertebrae in ovariectomized rats:anthropometrical andmechanical Analyses显示文摘 | Simoes PA Zamarioli A Bloes P | 2008 | Acta of Bioengineering and Biomechan-ics2008，10，2： | 1 |
| 17 | Uncostrained springback behaviour of Al-Mg-Si sheets for different sitting times显示文摘 | de Sousa R J A Correia J P M Simoes F J P | 2008 | lnternatioal Journal of Mechanical sciences2008，50，9： | 1 |
| 18 | Antimicrobialactivity of garlic, tea tree oil, and chlorhexidine against oral mi-croorganisms 显示文摘 | GROPPO F C RAMACCIATO J C SIMOES R P | 2002 | Int Dent J2002，52，6： | 1 |
| 19 | Effect of treadmill exercise on lumbar vertebrae in ovariectomized rats: anthropometrical and mechanical analyses显示文摘 | Simoes PA Zamarioli A Bloes P | 2008 | Acta Bioeng Biomech2008，10，2： | 1 |
| 20 | Prevalence of human papillomavirus in breast cancer: a systematic review显示文摘 | Simoes P W Medeiros L R Simoes Pires P D | 2012 | Int J Gynecol Cancer2012，22，3： | 1 |
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