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| 1 | Deep sedation during gastrointestinal endoscopy: Propofol-fentanyl and midazolam-fentanyl regimens显示文摘AIM: To compare deep sedation with propofol-fentanyl and midazolam-fentanyl regimens during upper gastrointestinal endoscopy. METHODS: After obtaining approval of the research ethics committee and informed consent, 200 patients were evaluated and referred for upper gastrointestinal endoscopy. Patients were randomized to receive propofol-fentanyl or midazolam-fentanyl (n = 100/group).We assessed the level of sedation using the observer's assessment of alertness/sedation (OAA/S) score and bispectral index (BIS). We evaluated patient and physician satisfaction, as well as the recovery time and complication rates. The statistical analysis was performed using SPSS statistical software and included the MannWhitney test, χ 2 test, measurement of analysis of variance, and the κ statistic. RESULTS: The times to induction of sedation, recovery, and discharge were shorter in the propofolfentanyl group than the midazolam-fentanyl group. According to the OAA/S score, deep sedation events occurred in 25% of the propofol-fentanyl group and 11% of the midazolam-fentanyl group (P = 0.014). Additionally, deep sedation events occurred in 19% of the propofol-fentanyl group and 7% of the midazolamfentanyl group according to the BIS scale (P = 0.039). There was good concordance between the OAA/S score and BIS for both groups (κ = 0.71 and κ = 0.63, respectively). Oxygen supplementation was required in 42% of the propofol-fentanyl group and 26% of the midazolam-fentanyl group (P = 0.025). The mean time to recovery was 28.82 and 44.13 min in the propofolfentanyl and midazolam-fentanyl groups, respectively (P < 0.001). There were no severe complications in either group. Although patients were equally satisfied with both drug combinations, physicians were more satisfied with the propofol-fentanyl combination. CONCLUSION: Deep sedation occurred with propofolfentanyl and midazolam-fentanyl, but was more frequent in the former. Recovery was faster in the propofol-fentanyl group. | Marcos Eduardo Lera dos Santos Fauze Maluf-Filho Dalton Marques Chaves Sergio Eiji Matuguma Edson Ide Gustavo de Oliveira Luz Thiago Ferreira de Souza Fernanda C Simoes Pessorrusso Eduardo Guimares Hourneaux de Moura Paulo Sakai | 2013 | World Journal of Gastroenterology2013，19，22： | 16 |
| 2 | A class of mixed assumed strain methods and the method of incompatible modes显示文摘 | Simo J C Rifai M S | 1990 | International Journal for Numerical Methods in Engineering1990，29，： | 2 |
| 3 | Influence of Temperature on the Dielectric and Ferroelectric Properties of Bismuth Titanate Thin Films Obtained by the Polymeric Precursor Method 显示文摘 | Simoes A Z Ramireic M A Riccardi C S | 2005 | Materials Chemistry and Physics2005，92，23： | 1 |
| 4 | Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae) 显示文摘 | Kuete V Ngameni B Fotso Simo C C | 2008 | J Ethnopharmacol2008，120，1： | 1 |
| 5 | Risk factors for severerespiratory syncytial virus lower respiratory infection显示文摘 | Sommer C Resch B Simoes EAF | 2011 | OpenMicrobiol J2011，5，24： | 1 |
| 6 | A perturbed Lagrangian formulation for the finite element solution of contact problems显示文摘 | Wriggers P Taylor R L | 1985 | Comp Meth Appl Mech Engng1985，50，： | 1 |
| 7 | (Symmetric) Hessian for geometrically nonlinear models in solid mechanics, intrinsic definition and geometric interpretation 显示文摘 | Simo J C | 1992 | Computer Methods in Applied Mechanics and Engineering1992，96，： | 1 |
| 8 | A perturbed Lagrangian formulation for the finite element solution of contact problems显示文摘 | SIMO J C WRIGGER P TAYOR R L | 1985 | Computer Methods in Applied Mechanics and Engineering1985，50，16： | 1 |
| 9 | lntravitreous anti-VEGF for diabetic retinopathy:hopes and fears for a new therapeutic stratrgy 显示文摘 | Simo R Herncndez C | 2008 | Diabetologia2008，51，9： | 1 |
| 10 | Proinflammatory responses of heine in alveolar macrophages: repercussion in lung hemorrhagic episodes显示文摘 | Simoes R L Arruda M A Canetti C | 2013 | Mediators Infiamm2013，2013，94： | 1 |
| 11 | An augmented lagrangian treament of contact problems involving friction显示文摘 | Simo J C Laursen T A | 1992 | Computers and Structures1992，42，1： | 1 |
| 12 | Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novelnoninvasive treatment by SOD in transfersomes 显示文摘 | Simoes S I Delgado T C Lopes R M | 2005 | J Controlled Release2005，103，2： | 1 |
| 13 | Entropy-based Synthesis of Pretensioned Cable Net Structures显示文摘 | Simoes L M C Templeman A B | 1989 | Engineering Optimization1989，15，2： | 1 |
| 14 | Genetic dissection of al tolerance qtls in the maize genome by high density snp scan 显示文摘 | Guimaraes C T Simoes C C Pastina M M | 2014 | BMC Genomics2014，15，： | 1 |
| 15 | Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity显示文摘 | Fonseca C Simoes S Gaspar R | 2002 | J Control Release2002，83，2： | 1 |
| 16 | Strain and stress-based continuum damagemodels 显示文摘 | Simo J C Ju J W | 1987 | International Journal Sofids Structures1987，23，： | 1 |
| 17 | A return mapping algorithm for plane stress elastoplasticity 显示文摘 | Simo J C Taylor R L | 1986 | International Journal for Numerical Methods in Engineering1986，22，： | 1 |
| 18 | Free insulin-like growth factor I in the vitreous fluid of diabetic patients with proliferative diabetic retinopathy:a case-control study显示文摘 | Simo R Hernandez C Segura RM | 2003 | Clin Sci2003，104，： | 1 |
| 19 | Consistent tangent operator for rate-independent elastoplasticity 显示文摘 | Simo J C Taylor R L | 1985 | Computers Methods in Applied Mechanics and Engineering1985，48，： | 1 |
| 20 | Pulse processing architectures 显示文摘 | Simoes J B Correia C M B A | 1999 | Nuel Instr and Meth in Phys Research1999，422，： | 1 |
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