|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Contributions of pre-silking assimilates to grain yield of maize显示文摘 | SIMMONS S R JONES R J | 1985 | Crop Sci1985，25，： | 1 |
| 3 | Characteristics and genesis of epithermal gold deposits 显示文摘 | Cooke D R Simmons S F | 2000 | Reviews in Economic Geology2000，13，2： | 1 |
| 4 | Functional subdivisions within anterior cingulated cortex and their relationship to autonomic nervous system function显示文摘 | Matthews S C Paulus M P Simmons A N Nelesen R A Dimsdale J E | 2004 | NeuroImage2004，22，： | 1 |
| 5 | Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization 显示文摘 | SIMMONS R THEVARAJAH S BRENNAN M B | 2003 | Ann Surg Oncol2003，10，： | 1 |
| 6 | Airway regional anesthesia for awake fiberoptic intubation显示文摘 | SIMMONS S T SCHLEICH A R | 2002 | Reg Anesth Pain Med2002，27，： | 1 |
| 7 | Guanxi Versus the Market:Ethics and Efficiency显示文摘 | LOVETT S SIMMONS L KALI R | 1999 | Journal of International Business Studies1999，30，2： | 1 |
| 8 | Companion crop forage establishment: Producer practices and perceptions显示文摘 | Simmons S R Martin N P Sheafer C C | 1992 | Journal of Production Agriculture1992，5，： | 1 |
| 9 | Contributions of pre-silking assimilate to grain yield on maize 显示文摘 | SIMMONS S R JONES R J | 1985 | Crop Science1985，25，： | 1 |
| 10 | Relationships among students and graduate caring ability and professional school climate显示文摘 | SIMMONS P R CAVANAUGH S H | 2000 | J Prof Nurs2000，16，2： | 1 |
| 11 | Effect of the angle of the femoral and tibial tunnels in the coronal plane and incremental excision of the posterior cruciate ligament on tension of an anterior crueiate ligament graft: an in vitro study显示文摘 | SIMMONS R HOWELL S M HULL M L | 2003 | J Bone Joint Surg (Am)2003，85，6： | 1 |
| 12 | Duck plague (duck virus enteritis) in Britain显示文摘 | Hall S A Simmons J R | 1972 | Vet Rec1972，90，24： | 1 |
| 13 | Contributions of pre-silking assimilate to grain yield in maize显示文摘 | Simmons S R Jones R J | 1985 | Crop Science1985，25，6： | 1 |
| 14 | Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization 显示文摘 | Simmons R Thevarajah S Brennan MB | 2003 | Ann Surg Oncol2003，10，3： | 1 |
| 15 | A comparison of the adverse reactions associated with isosulfan blue versus methylene blue dye in sentinel lymph ode biopsy for breast cancer显示文摘 | THEVARAJAH S HUSTON T L SIMMONS R M | 2005 | Am J Surg2005，189，： | 1 |
| 16 | Rate and duration of growth of kernels formed at soecific florets in spikelets of spring wheat显示文摘 | Simmons S R Crookston R K | 1979 | Crop Science1979，19，： | 1 |
| 17 | Relationships among student and graduate caring ability and professional school climate显示文摘 | Simmon P R Cavanaugh S H | 2000 | J Prof Nuts2000，16，2： | 1 |
| 18 | 显示文摘 | Simmons R F Davidson R | 1992 | IEEE Trans Magn1992，28，： | 1 |
| 19 | Quantitative measurements of force and displacement using an optical trap显示文摘 | SIMMONS R M FINER J T CHU S | 1996 | Biophysical Journal1996，70，： | 1 |
| 20 | Water Deprivation Activates a Glutamatergie Projection from the Hypothalamic Paraventricular Nucleus to the Rostral Ventrolateral Nedulla 显示文摘 | STOCKER S D SIMMONS J R STORNETTA R L | 2006 | Comp Neurol2006，494，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员