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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | 显示文摘 | Butler P E Cao Y L | 1998 | Plast Reconstr Swry1998，10，6： | 1 |
| 3 | How Does Plant Population Density Affect the Forage Yield of Eastern Gamagrass显示文摘 | Springer T L Dewald C L Sims P L | 2003 | Crop Science2003，43，： | 1 |
| 4 | Supercritical carbon dioxide extraction efficiency for carotenes from carrots by RSM显示文摘 | Balaban M O Sims C A | 1996 | Journal of Food Science1996，61，75： | 1 |
| 5 | Salbutamol prevents the increase of respiratory resistance caused by tracheal intubation during sevoflurane anesthesia in asthmatic children 显示文摘 | Scalfaro P Sly PD Sims C | 2001 | Anesth Analg2001，93，4： | 1 |
| 6 | Colour, polyphenoloxidases and sensory changes in banana juice as affected by heat and UF显示文摘 | Sims C A Bates R P Arreola A G | 1994 | Food Qual1994，，17： | 1 |
| 7 | Vertical versus shared leadship as predictors of the effectiveness of change management teams显示文摘 | PEARCE C L SIMS H P | 2002 | Group Dynamics Theory Research and Practice2002，6，2： | 1 |
| 8 | Job Stressors and Satisfaction in the Nursing Staff of a Critical Unit显示文摘 | Simón M G Blesa A M Bermejo P C | 2005 | Enferm Intensiva2005，16，1： | 1 |
| 9 | Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia:a multi-variate analysis by Cox regression in141patients显示文摘 | CHIM C S SIM J P CHAN C C | 2010 | Hematology2010，15，： | 1 |
| 10 | Application of CFD in the study of supercritical fluid extraction with structured packing: wet pressure drop calculations显示文摘 | FERNANDES J LISBOA P F SIM(7)ES P C | 2009 | The Journal of SupercriticalFluids2009，50，1： | 1 |
| 11 | Quantitative estimates of water tables and soil moisture in Holocene pestlands from testate amoebae显示文摘 | Woodland W A Charman D J Sims P C | 1998 | The Holocene1998，8，3： | 1 |
| 12 | Vertical versus shared leader- ship as predictors of the effectiveness of change manage- ment teams : An examination of aversive, directive, transactional, transformational and empowering leader behaviors 显示文摘 | Pearce C L Sims Jr H P | 2002 | Group Dynamics2002，，6： | 1 |
| 13 | Effects of skin fermentation time on the phenols, anthocyanins, ellagic acid sediment, and sensory characteristics of a red Vitis rotundifolia Wine显示文摘 | Bates R P | 1994 | Am J Enol Vitic1994，45，1： | 1 |
| 14 | Low pH inactivation of polyphenoloxidase in apple juice显示文摘 | ZEMEL G P SIMS C A MARSHALL M R | 1990 | Journal of Food Science1990，55，2： | 1 |
| 15 | HMGB1 and RAGE in inflammation and cancer显示文摘 | Sims G P Rowe D C Rictdijk S T | 2010 | Annu Rev Immunol2010，28，： | 1 |
| 16 | Genetic relationships within tripsaeum as detected by RAPD variation显示文摘 | Li Y G Dewald C L Sims P L | 1999 | Annals of Botany1999，84，： | 1 |
| 17 | Top manage- ment team diversity, group process and strategic consensus 显示文摘 | Knight D Pearce C L Smith K G Olian J D Sims H P Smith K A Flood P | 1999 | Strategic Management Journal1999，，20： | 1 |
| 18 | SCIP/Oct26, Krox220, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells显示文摘 | SMITH P M SIM F J BARNETF S C | 2001 | Glia2001，36，3： | 1 |
| 19 | Is photody-namic diagnosis using hypericin better than white-light cysto-scopy for detecting superficial bladder carcinoma? 显示文摘 | Sim H G Lau W K Olivo M Tan P H Cheng C W | 2005 | BJUInt2005，95，： | 1 |
| 20 | Application of CFD in the study of supercritical fluid extraction with structured packing:Wetpressure drop calculations显示文摘 | Fernandes J Lisboa P F Sim?es P C | 2009 | Supercritical Fluids2009，50，： | 1 |
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