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| 1 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 2 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | Effect of various growth media upon survival during storage of freeze - dried Enterocoeeus faeealis and Enteroeoceus durans显示文摘 | Carvalho AS Silva J | 2003 | J Appl Microbiol2003，94，6： | 1 |
| 4 | Linear viscoelasticity of disordered polystyrene-polyisoprene block copolymer based layered-silicate nanocomposites显示文摘 | Ren J Silva AS Krishnamoorti R | 2000 | Macromolecules2000，33，： | 1 |
| 5 | Uric acidlevels are associated with microvascular endothelialdysfunction in patients with Type 1 diabetes 显示文摘 | Matheus AS Tibiri?6 E da Silva PB | 2011 | DiabetMed2011，28，10： | 1 |
| 6 | The use of a DNA stabilizer in human dental tissues stored under different temperature conditions and time intervals显示文摘 | Terada AS Silva LA Galo R | 2014 | J Appl Oral Sci2014，22，4： | 1 |
| 7 | In vitro evaluation of the efficacy of commercial green tea extracts in UV protection 显示文摘 | Silva AR Seidl C Furusho AS | 2013 | Int J Cosmet Sci2013，35，1： | 1 |
| 8 | MAPKs are key players in mediating cytokine release and cell death induced by unconjugated biliribin in cultured rat cortical astrocytes显示文摘 | FEMANDES A FALCAO AS SILVA RF | 2007 | Eur J Neurosci2007，25，4： | 1 |
| 9 | Role of carbon monoxide in L-glutamate-induced cardiovascular responses in neucleus tractus solitarily of contious rats显示文摘 | Silva CC Almeida VA Haibara AS | 1999 | Brain Res1999，824，： | 1 |
| 10 | Isolation of 2-pyridone alkaloides form a new zealand marine derived Penicillium species显示文摘 | DE SILVA ED GEIERMANN AS MITOVA MI | 2009 | J Nat Prod2009，72，3： | 1 |
| 11 | Uric acid levels are associated with microvascular endothelial dysfunction in patients with type 1 diabetes显示文摘 | Matheus AS Tibiri9h E da Silva PB | 2011 | Diabet Med2011，28，10： | 1 |
| 12 | Antibiotic susceptibility of potentially probiotic vaginal lactobscilli 显示文摘 | Oca a V Silva C Nader-Mac as ME | 2006 | Infectious Diseases in Obstetrics and Gyneoology2006，，： | 1 |
| 13 | Protective effect of sorbitol and monosodium glutamate during storage of freeze-dried lactic acid bacteria显示文摘 | Carvalho AS Silva J Ho P | 2003 | Le Lair2003，83，： | 1 |
| 14 | Cognitive impairments in patients with low grade gliomas and high grade gliomas 显示文摘 | Miotto EC Junior AS Silva CC | 2011 | Arq Neuropsiquiatr2011，69，： | 1 |
| 15 | Increase in the woody component of seasonal savannas under different fire regimes in Calabozo, Venezuela显示文摘 | SILVA J F ZAMBRANO A FARI AS M R | 2001 | Journal ofBiogeography2001，28，8： | 1 |
| 16 | Dissociated primary nerve cell cultures as models for assessment of neurotoxicity显示文摘 | Silva RFM Falcao AS Femandes A | 2006 | Toxicology Letters2006，163，1： | 1 |
| 17 | Me- chanical properties of light-curing composites polymerized with different laboratory photo-curing units显示文摘 | da Silva GR Simamoto-Jfinior PC da Mota AS | 2007 | Dent Mater J2007，26，2： | 1 |
| 18 | Protein extraction and comparison of stain protocols for analysis of two-dimensional electrophoresis gels显示文摘 | Silva J Carvalho AS Vitorino R | 2004 | Protein Pept Lett2004，11，2： | 1 |
| 19 | Prevalence of Acanthosis Nigricans in an urban population in Sfi Lanka and its utility to detect metabolic syndrome显示文摘 | Dassanayake AS Kasturiratne A Niriella MA Kalubovila U Rajindrajith S de Silva AP | 2011 | BMC Res Notes2011，4，1： | 1 |
| 20 | Anemia,renal dysfunction,and their interaction in patients with chronic heart failure显示文摘 | de Silva R Rigby AS Witte KK | 2006 | Am J Cardiol2006，98，3： | 1 |
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