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| 1 | Primary malignant melanoma of the esophagus:A case report显示文摘The authors present the clinical case of an 87-year-old Caucasian male admitted to the emergency room with hematemesis. He had a history of intermittent dys-phagia during the previous month. Endoscopic evaluation revealed an eccentric,soft esophageal lesionlocated 25-35 cm from the incisors,which appeared asa protrusion of the esophagus wall,with active bleeding. Biopsies were acquired. Tissue evaluation wascompatible with a melanoma. After excluding other sites of primary neoplasm,the definitive diagnosis of Primary Malignant Melanoma of the Esophagus(PMME) was made. The patient developed a hospital-acquired respiratory infection and died before tumor-directed treatment could begin. Primary malignant melanoma represents only 0.1% to 0.2% of all esophageal ma-lignant tumors. Risk factors for PMME are not defined.A higher incidence of PMME has been described in Japan. Dysphagia,predominantly for solids,is the most frequent symptom at presentation. Retrosternal orepigastric discom fort or pain,melena or hemate mesishave also been described. The characteristic endoscopic finding of PMME is as a polypoid lesion,with variablesize,usually pigmented. The neoplasm occurs in thelower two-thirds of the esophagus in 86% of cases.PMME metastasizes via hematogenic and lymphatic pathways. At diagnosis,50% of the patients present with distant metastases to the liver,the mediastinum,the lungs and the brain. When possible,surgery(curative or palliative) ,is the preferential method of treatment. There are some reports in the literature where chemotherapy,chemohormon otherapy,radiotherapy and immunotherapy,with or without surgery,wereused with variable efficacy. The prognosis is poor;themean survival after surgery is less than 15 mo. | Joana Machado Paula Ministro Ricardo Araújo Eugénia Cancela António Castanheira Américo Silva | 2011 | World Journal of Gastroenterology2011，17，42： | 6 |
| 2 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 3 | Gemcit- abine and cisplatin salvage regimen in heavily pretreated meta- static breast cancer: a Brazilian experience 显示文摘 | de Lima Arat:jo LH Moitinho MV Silva AM | 2011 | Med Oncol2011，28，1： | 1 |
| 4 | Phthalate exposure and reproductive hormones in adult men 显示文摘 | Duty SM Calafat AM Silva MJ | 2005 | Hum Reprod2005，20，： | 1 |
| 5 | Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia 显示文摘 | Silva AQ Schreihofer AM | 2011 | J Physiol2011，5896，： | 1 |
| 6 | Epidemiology of,and behavioural risk factors for,sexually transmitted human papilloma virus infection in a sample of the British population显示文摘 | Mercer CH Johnson AM de Silva N | 2011 | Sex Transm lnf2011，87，6： | 1 |
| 7 | The relationship of stress and anxiety with chronic periodontitis显示文摘 | Vettore MV Leito AT Monteiro Da Silva AM | 2003 | J Clin Periodontol2003，30，5： | 1 |
| 8 | Eval- uation of IL17A expression and of IL17A, IL17F and IL-23R gene polymorphisms in Brazilian individuals with periodontitis 显示文摘 | Saraiva AM Alvese Silva MR Correia Silva Jde F | 2013 | Hum Immunol2013，74，2： | 1 |
| 9 | Psyehosocial factors in inflammatory periodontal diseases A review显示文摘 | Monerio da silva AM Newman HN Oaklay DA | 1995 | J Clin Periodontol1995，22，7： | 1 |
| 10 | Central nervous system site of action for the respiratory depressant effect of diacetylmorphine (heroin) in the cat显示文摘 | Taveira da Silva AM Souza JD Quest | 1983 | J Clin Invest1983，72，4： | 1 |
| 11 | Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria 显示文摘 | Cunha-Oliveira T Silva L Silva AM | 2013 | Toxicol Lett2013，219，3： | 1 |
| 12 | Effect of Bifidobacterium longum ingestion on experimental salmonellosis in mice显示文摘 | Silva AM Barbosa FH Duarte R | 2004 | J Appl Microbiol2004，97，1： | 1 |
| 13 | The role of KIR2DS1 in multiple sclerosis-KIR in Portuguese MS patients显示文摘 | Bettencourt A Silva AM Carvalho C | 2014 | J Neuroim- munol2014，269，12： | 1 |
| 14 | Development of a device to measure bracket debonding force in vivo 显示文摘 | Prietsch JR Spohr AM Lima da Silva IN | 2007 | Eur J Orthod2007，29，6： | 1 |
| 15 | Progressive load training for the quadriceps muscle associated with proprioception exercises for the prevention of falls in postmenopausal women with osteoporosis:a randomized controlled trial显示文摘 | Teixeira LE Silva KN Imoto AM | 2010 | Osteoporos Int2010，21，4： | 1 |
| 16 | Initial experience with the buttonhole technique in a brazilian hemodialysis center 显示文摘 | Silva GS Silva RA Nicolino AM | 2010 | J Bras Nefrol2010，32，3： | 1 |
| 17 | Use of chitosan membrane associated with polypropylene mesh to prevent peritoneal adhesion in rats显示文摘 | Paulo NM de Britoe Silva MS Moraes AM | 2009 | J Biomed Mater Res B Appl Biomater2009，91，1： | 1 |
| 18 | Neovascular growth fol-lowing photodynamic therapy for choroidal hemangioma andneovascular regression after intraviteous injection of triamcin-olone 显示文摘 | Leys AM Silva R Inhoffen W Tatar O | 2006 | Retina2006，26，6： | 1 |
| 19 | The prevalence of wheezing and its association with body mass index and abdominal obesity in children显示文摘 | Silva Rde C Assis AM Goncalves MS | 2013 | J Asthma2013，50，3： | 1 |
| 20 | Ranibizumab treat- ment for choroidal neovascularization from causes other than age -related maeular degeneration and pathological myopia显示文摘 | Carneiro AM Silva RM Veludo MJ | 2011 | Oph- thalmologica2011，225，2： | 1 |
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