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| 1 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 2 | Enhancement by IL-12 of the cytolytic T lymphocyte (CTL) response of mice immunized with tumor-specific peptides in an adjuvant containing QS21 and MPL显示文摘 | Fallarino F Boon T | 1999 | Eur Cytokine Netw1999，10，2： | 1 |
| 3 | Ant system for the set coveting problem显示文摘 | Ricardo M de A Silla Geber L Ramalho | 2001 | IEEE Transactions on Evolutionary Computation2001，，1： | 1 |
| 4 | Amino acid deearboxylase capability of microorganisms isolated in Spanish fermented meat products 显示文摘 | Silla Santos M H | 1998 | International Journal Food Microbiology1998，39，： | 1 |
| 5 | CD40 ligation ablates the tolerogenic potential of lymphoid dendritic cells显示文摘 | Grohmann U Fallarino F Silla S | | 0，，： | 1 |
| 6 | Brd4 is involved in multiple processes of the Bovine Papillomavirus Type 1 life cycle显示文摘 | lives Ⅰ Maemets K Silla T | 2006 | J Virol2006，80，： | 1 |
| 7 | Orthodontic treatment need in a 12-year-oldpopulation in the Western Sahara显示文摘 | Puertes- Fernandez N Montiel- Company JM Almerich- Silla JM | 2011 | Eur J Orthod2011，33，4： | 1 |
| 8 | Association of blood uric acid with other cardiovascular risk factors in the male working population in Valencia 显示文摘 | Corella D Silla J Ordovas JM | 1999 | Rev Clin Esp1999，199，： | 1 |
| 9 | Biogenic amines: their importance in foods显示文摘 | Silla Santos M H | 1996 | International Journal of Food Microbiology1996，，29： | 1 |
| 10 | Biogenic amines:their importance in foods显示文摘 | SILLA S M H | 1996 | Interna-tional Journal of Food Microbiology1996，29，： | 1 |
| 11 | Biogenic amines: their importance in foods显示文摘 | Silla Santos M H | 1996 | International Journal of Food Microbiology1996，29，： | 1 |
| 12 | Biogenic amines: their importance in foods显示文摘 | Silla Santos MH Santos | 1996 | Int J Food Microbiol1996，29，23： | 1 |
| 13 | Biogenic amines:their importance in foods显示文摘 | SILLA SANTOS M H | 1996 | Int J Food Microbiol1996，29，23： | 1 |
| 14 | Biogenic amines: their importance infoods显示文摘 | Silla Santos M H | 1996 | Int J Food Microbiol1996，29，： | 1 |
| 15 | Electrophysiologic changes following treatment with organophosphorus- induced delayed neuropathy- producing agents in the adult hen显示文摘 | Robertson DG Schwab BW Silla RD | 1987 | Toxicology and Appled Pharmacology1987，87，： | 1 |
| 16 | ETV6/RUNX1 fusion lacking prognostic effect in pediatric patients with acute lymphoblastic leukemia显示文摘 | Zen P Capra M Silla L | 2009 | Cancer Genet Cytogenet2009，188，2： | 1 |
| 17 | Episomal maintenance ofplasmids with hybrid origins in mouse cells显示文摘 | Silla T H(aa)l I Geimanen J | | 0，，24： | 1 |
| 18 | Biogenic amines: their importance in foods 显示文摘 | Silla Santos M H | 1996 | International Journal of Food Microbiology1996，29，23： | 1 |
| 19 | Biogenic amines: their importance in foods显示文摘 | SILLA S M H | 1996 | International Journal of Food Microbiology1996，29，： | 1 |
| 20 | Amino acid chemistry in solution: structural properties and vibrational dynamics of serine using density functional theory and a continuum solvent model 显示文摘 | RAMIREZ F J TUNON I SILLA E | 2004 | Chem Phys2004，303，12： | 1 |
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