|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Moving forward in the treatment of cholangiocarcinoma显示文摘Despite being the second most frequent primary liver tumor in humans,early diagnosis and treatment of cholangiocarcinoma(CCA)are still unsatisfactory.In fact,survival after 5 years is expected in less than one fourth of patients diagnosed with this disease.Rare incidence,late appearance of symptoms and heterogeneous biology are all factors contributing to our limited knowledge of this cancer and determining its poor prognosis in the clinical setting.Several efforts have been made in the last decades in order to achieve an improved classification/understanding with regard to the diverse CCA forms.Location within the biliary tree has helped to distinguish between intrahepatic,perihilar and distal CCA types.Sequence analysis contributed to identifying several characteristic genetic aberrations in CCA that may also serve as possible targets for therapy.Novel findings are expected to significantly improve the management of this malignancy in the near future.In this changing scenario our review focuses on the current and future strategies for CCA treatment.Both systemic and surgical treatments are discussed in detail.The results of the main studies in this field are reported,together with the ongoing trials.The current findings suggest that an integrated multidisciplinary approach to this malignancy would be helpful to improve its outcome. | Tommaso M Manzia Alessandro Parente Ilaria Lenci Bruno Sensi Martina Milana Carlo Gazia Alessandro Signorello Roberta Angelico Giuseppe Grassi Giuseppe Tisone Leonardo Baiocchi | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 6 |
| 2 | Chronic rejection after liver transplantation:Opening the Pandora’s box显示文摘Chronic rejection(CR)of liver allografts causes damage to intrahepatic vessels and bile ducts and may lead to graft failure after liver transplantation.Although its prevalence has declined steadily with the introduction of potent immunosuppressive therapy,CR still represents an important cause of graft injury,which might be irreversible,leading to graft loss requiring re-transplantation.To date,we still do not fully appreciate the mechanisms underlying this process.In addition to T cell-mediated CR,which was initially the only recognized type of CR,recently a new form of liver allograft CR,antibody-mediated CR,has been identified.This has indeed opened an era of thriving research and renewed interest in the field.Liver biopsy is needed for a definitive diagnosis of CR,but current research is aiming to identify new non-invasive tools for predicting patients at risk for CR after liver transplantation.Moreover,the minimization or withdrawal of immunosuppressive therapy might influence the establishment of subclinical CR-related injury,which should not be disregarded.Therapies for CR may only be effective in the“early”phases,and a tailored management of the immunosuppression regimen is essential for preventing irreversible liver damage.Herein,we provide an overview of the current knowledge and research on CR,focusing on early detection,identification of non-invasive biomarkers,immunosuppressive management,re-transplantation and future perspectives of CR. | Roberta Angelico Bruno Sensi Tommaso M Manzia Giuseppe Tisone Giuseppe Grassi Alessandro Signorello Martina Milana Ilaria Lenci Leonardo Baiocchi | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 3 | COVID-19 in normal,diseased and transplanted liver显示文摘Starting from December 2019 the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has extended in the entire world giving origin to a pandemic.Although the respiratory system is the main apparatus involved by the infection,several other organs may suffer coronavirus disease 2019(COVID-19)-related injuries.The human tissues expressing angiotensin-converting enzyme 2(ACE2)are all possible targets of viral damage.In fact myocarditis,meningo-encephalitis,acute kidney injury and other complications have been described with regard to SARS-CoV-2 infection.The liver has a central role in the body homeostasis contributing to detoxification,catabolism and also synthesis of important factor such as plasma proteins.ACE2 is significantly expressed just by cholangiocytes within the liver,however transaminases are increased in more than one third of COVID-19 patients,at hospital admission.The reasons for liver impairment in the course of this infection are not completely clear at present and multiple factors such as:Direct viral effect,release of cytokines,ischemic damage,use of hepatotoxic drugs,sepsis,and others,may contribute to damage.While COVID-19 seems to elicit just a transient alteration of liver function tests in subjects with normal hepatic function,of concern,more severe sequelae are frequently observed in patients with a reduced hepatic reserve.In this review we report data regarding SARS-CoV-2 infection in subjects with normal or diseased liver.In addition the risks of COVID-19 in immunosuppressed patients(either transplanted or suffering for autoimmune liver diseases)are also described. | Alessandro Signorello Ilaria Lenci Martina Milana Giuseppe Grassi Leonardo Baiocchi | 2021 | World Journal of Gastroenterology2021，27，20： | 2 |
| 4 | Offspring heahh risk after cosmetic breast implantation in Sweden 显示文摘 | Signorello LB Fryzek JP Blot WJ | 2001 | Ann Hast Surg2001，46，3： | 1 |
| 5 | Impaired L-arginine uptake in platelets from type-2 diabetic patients显示文摘 | Signorello MG Giovine M Pascale R | 2001 | Biotechnol Appl Biochem2001，34，1： | 1 |
| 6 | Secondary bile acids and the biliary epithelia: The good and the bad显示文摘The biliary tract has been considered for several decades a passive system just leading the hepatic bile to the intestine.Nowadays several researches demonstrated an important role of biliary epithelia(i.e.cholangiocytes)in bile formation.The study of biliary processes therefore maintains a continuous interest since the possible important implications regarding chronic cholestatic human diseases,such as primary biliary cholangitis or primary sclerosing cholangitis.Bile acids(BAs),produced by the liver,are the most represented organic molecules in bile.The physiologic importance of BAs was initially attributed to their behavior as natural detergents but several studies now demonstrate they are also important signaling molecules.In this minireview the effect of BAs on the biliary epithelia are reported focusing in particular on secondary(deriving by bacterial manipulation of primary molecules)ones.This class of BAs is demonstrated to have relevant biological effects,ranging from toxic to therapeutic ones.In this family ursodeoxycholic and lithocholic acid present the most interesting features.The molecular mechanisms linking ursodeoxycholic acid to its beneficial effects on the biliary tract are discussed in details as well as data on the processes leading to lithocholic damage.These findings suggest that expansion of research in the field of BAs/cholangiocytes interaction may increase our understanding of cholestatic diseases and should be helpful in designing more effective therapies for biliary disorders. | Ilaria Lenci Martina Milana Alessandro Signorello Giuseppe Grassi Leonardo Baiocchi | 2023 | World Journal of Gastroenterology2023，29，2： | 1 |
| 7 | Contingent Valuation and Cultural Policy Design: The Case of Napoli Musei Aperti显示文摘 | Santagata W Signorello G | 2000 | Journal of Cultural Economics2000，24，3： | 1 |
| 8 | Effect of homo- cysteine on arachidonic acid release in human platelet 显示文摘 | SIGNORELLO M G PASCALE R LEONCINI G | 2002 | Eur J Clin Invest2002，32，4： | 1 |
| 9 | Activation of p38 MAPKinase/cPLA2 pathway in homocysteine - treated plate- lets显示文摘 | LEONCINI G BRUZZESE D SIGNORELLO MG | 2006 | J Thromb Haemost2006，4，1： | 1 |
| 10 | Sequence of events leading to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is a chronic cholestatic liver disease that is observed more frequently in middle-aged women.This disorder is considered an autoimmune disease,since liver injury is sustained by the presence of selfdirected antimitochondrial antibodies targeting the bile duct cells.The prognosis may vary depending on an early diagnosis and response to therapy.However,nearly a third of patients can progress to liver cirrhosis,thus requiring a liver transplant.Traditional immunosuppressive therapies,commonly employed for other autoimmune diseases,have limited effects on PBC.In fact,dramatic functional changes that occur in the biliary epithelium in the course of inflammation play a major role in perpetuating the injury.In this minireview,after a background on the disease and possible predisposing factors,the sequential cooperation of cellular/molecular events leading to end-stage PBC is discussed in detail.The rise and maintenance of the autoimmune process,as well as the response of the biliary epithelia during inflammatory injury,are key factors in the progression of the disease.The so-called“ductular reaction(DR)”,intended as a reactive expansion of cells with biliary phenotype,is a process frequently observed in PBC and partially understood.However,recent findings suggest a strict relationship between this pathological picture and the progression to liver fibrosis,cell senescence,and loss of biliary ducts.All these issues(onset of chronic inflammation,changes in secretive and proliferative biliary functions,DR,and its relationship with other pathological events)are discussed in this manuscript in an attempt to provide a snapshot,for clinicians and researchers,of the most relevant and sequential contributors to the progression of this human cholestatic disease.We believe that interpreting this disorder as a multistep process may help identify possible therapeutic targets to prevent evolution to severe disease. | Ilaria Lenci Paola Carnì Martina Milana Agreta Bicaj Alessandro Signorello Leonardo Baiocchi | 2023 | World Journal of Gastroenterology2023，29，37： | 1 |
| 11 | Insulin-likegrowth factor 1 in relation to prostate cancer and benignprostatic hyperplasia显示文摘 | Mantzoros CS Tzonou A Signorello LB | 1997 | Br J Cancer1997，76，： | 1 |
| 12 | Aspirin and risk for gastric cancer:a population-based case-control study in Sweden显示文摘 | Akre K Ekstrom A M Signorello L B | 2001 | Br J Cancer2001，84，7： | 1 |
| 13 | Total homo-cysteine reactive oxygen species and nitric oxide in type 2 dia-betes mellitus显示文摘 | Signorello MG Viviani GL Armani U | 2007 | Thromb Res2007，120，4： | 1 |
| 14 | Aspirin and risk for gastric cancer : a population-based case-control study in Sweden显示文摘 | Akre k Ekstrom A M Signorello L B | 2001 | Br J Cancer2001，84，7： | 1 |
| 15 | Leptin in relation to prostate cancer and benign prostatic hyperplasia 显示文摘 | LagiouP Signorello LB Trichopoulos D | 1998 | Int J Cancer1998，7，6： | 1 |
| 16 | Aspirin and risk for gastric cancer:a population -based case - control study in Sweden显示文摘 | AKRE K EKSTROM AM SIGNORELLO LB | 2001 | Br J Cancer2001，84，7： | 1 |
| 17 | Activation of p38 MAPKinase/cPLA2 pathway in homocysteine-treated platelets显示文摘 | Leoncini G Bruzzese D Signorello MG | 2006 | J Thromb Haemost2006，4，1： | 1 |
| 18 | Reproductive correlates of chronic fatigue syndrome显示文摘 | Harlow BL Signorello LB | 1998 | Am J Med1998，108，： | 1 |
| 19 | Evaluation of 11 breast cancer susceptibility loci in African-American women显示文摘 | Zheng W Cai Q Signorello LB | | 0，，10： | 1 |
| 20 | Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D levels among african americans 显示文摘 | SIGNORELLO L B SHI J CAI Q | 2011 | PLoS ONE2011，6，28： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员