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| 1 | Diagnostic criteria for acute liver failure due to Wilson disease显示文摘AIM: To describe the diagnostic criteria for acute liver failure due to Wilson disease (WD), which is an uncommon cause of acute liver failure (ALF). METHODS: We compared findings of patients presenting with ALF due to WD to those with ALF of other etiologies. RESULTS: Previously described criteria, such as low alkaline phosphatase activity, ratio of low alkaline phosphatase to total bilirubin or ratio of high aspartate aminotransferase (AST) to alanine aminotransferase (ALT), failed to identify patients with ALF due to WD. There were significant differences in low ALT and AST activities (53 ± 43 vs 1982 ± 938, P < 0.0001 and 87 ± 44 vs 2756 ± 2941, P = 0.037, respectively), low choline esterase activity (1.79 ± 1.2 vs 4.30 ± 1.2, P = 0.009), high urine copper concentrations (93.4 ± 144.0 vs 3.5 ± 1.8, P = 0.001) and low hemoglobin (7.0 ± 2.2 vs 12.6 ± 1.8, P < 0.0001) in patients with ALF caused by WD as compared with other etiologies. Interestingly, 4 of 7 patients with ALF due to WD survived without liver transplantation. CONCLUSION: In ALF, these criteria can help establish a diagnosis of WD. Where applicable, slit- lamp examination for presence of Kayser-Fleischer rings and liver biopsy for determination of hepatic copper concentration still remain important for the diagnosis of ALF due to WD. The need for liver transplantation should be evaluated carefully as the prognosis is not necessarily fatal. | Christoph Eisenbach Olivia Sieg Wolfgang Stremmel Jens Encke Uta Merle | 2007 | World Journal of Gastroenterology2007，13，11： | 14 |
| 2 | First clinical trial of a newly developed capsule endoscope with panoramic side view for small bowel: A pilot study显示文摘 | Kilian Friedrich Sven Gehrke Wolfgang Stremmel Andreas Sieg | 2013 | J Gastroenterol Hepatol2013，，9： | 4 |
| 3 | Perspectives of colorectal cancer screening in Germany 2009显示文摘Adequate screening methods can decrease colorectal cancer(CRC) mortality.The guaiac test for fecal occultblood(FOBT) is part of the German CRC Screening Program since 1970 and has evidence level Ia.In randomized multicenter-studies FOBT has an average sensitivity of 24% and decreases CRC mortality up to 30%.Immunological tests for human haemoglobin(iFOBT) show better performance characteristics than guaiac FOBT,with augmented sensitivity and specificity.However,the single tests show wide differences in diagnostic performance and iFOBT is not yet covered by insurance companies although it should replace the guaiac test for CRC screening.Visual colonoscopy,which was introduced to the German National Cancer Screening Program in 2002,is the gold standard for the diagnosis of colorectal neoplasia.From 2003 to 2007 more than 2.8 million examinations have been documented in Germany.The prevalence of adenomas is around 20% and of CRC about 0.7% to 1.0% of the screenings.Seventy percent of the carcinomas detected during screening are in an early stage(UICCⅠand Ⅱ).Furthermore,screening colonoscopy is a cost saving procedure with a low complication rate(0.25% overall).Insurance companies save 216€ for each screening colonoscopy mainly by prevention of neoplasia due to polypectomy.In Germany,virtual colonography by computed tomography(CT) or magnetic resonance imaging still lacks standardization of the hard and software.In experienced centres the sensitivity for CRC and large polyps of CT colonography is comparable to colonoscopy but in meta-analyses the ranking is lower.New technologies like computer-aided colonoscopies with sheath or double balloon techniques are coming up as well as capsule colonoscopy,which sensitivity for large polyps is about 70%.Advised by his physician,the patient can choose his most acceptable examination method from this whole set of screening tools. | Andreas Sieg Kilian Friedrich | 2009 | World Journal of Gastrointestinal Endoscopy2009，1，1： | 2 |
| 4 | Capsule endoscopy compared with conventional colonoscopy for detection of colorectal neoplasms显示文摘Colon capsule endoscopy(CCE) may be a means to overcome the low adherence to colorectal cancer screening. The device is an ingestible capsule with a video camera at both ends that can take photographs as it progresses through the gastrointestinal tract.PillCam colon(PCC1) may be used for structural evaluation of the large bowel following an adequate cleaning procedure.PCC1 measures 11 mm×31 mm and has dual cameras that enable the device to acquire video images from both ends with a wide coverage area,automatic light control and a frame rate of four frames per second.The system includes a sensor array and data recorder connected to the patient during the procedure.The recorded data are downloaded to the Given Imaging Rapid workstation for review of the colon video.The second generation of PillCam Colon(PCC2) is similar to PCC1 and incorporates new developments.The angle of view has been increased to 172 degrees.It has an adaptive frame rate,alternating from 35 frames per second while in motion to 4 images when virtually stationary.The new RAPIDsoftware now includes a simple graphic interface tool for polyp size estimation.The procedure of bowel cleansing until capsule ingestion is similar to that used for traditional colonoscopy.However it is more rigorous as the bowel cleanliness for capsule colonoscopy has to be excellent or at least good to result in an adequate sensi-tivity of the method.Briefly,it consists of 3.5-4 L of split dose polyethylene glycol.Oral NaP boosters are administered after 1-2 h if the capsule has entered the small bowel.Sodium phosphate(NaP) seems to be a necessary adjunct to the regimen because the total transit time is doubled without NaP.The cleansing level was considered to be good to excellent in 72%-88%in studies with PCC1.The sensitivity for significant polyps(>6 mm or more than 3 polyps>3 mm) ranged from 63%-88% with specificities between 64%-94%.PCC2 showed an improved sensitivity of 89%and a specificity of 76%. CCE seems to be a safe and effective method of visualizing the colonic mucosa through colon fluids without the need for sedation or insufflation of air.The sensitivity of CCE to detect polyps,advanced adenomas and cancer is lower compared to optical colonoscopy but improvements will be made in the near future.With an increased recording duration,even a panenteric examination of the whole gastrointestinal tract may be possible. | Andreas Sieg | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，5： | 2 |
| 5 | S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL显示文摘 | C. Pox S. Aretz S. Bischoff U. Graeven M. Hass P. Heu?ner W. Hohenberger A. Holstege J. Hübner F. Kolligs M. Kreis P. Lux J. Ockenga R. Porschen S. Post N. Rahner A. Reinacher-Schick J. Riemann R. Sauer A. Sieg W. Scheppach W. Schmitt H. Schmoll K. Schulm | 2013 | Z Gastroenterol2013，，08： | 2 |
| 6 | Usefulness of ovarian volume and cysts in female is osexual precocbus puberty 显示文摘 | KING L R SIEGE I M J SOBMON A L | 1993 | J Ultrasound in Medicine1993，12，10： | 1 |
| 7 | TI - Microvascular submandibular gland transfer for severe cases of keratoconjunctivitis sicca显示文摘 | Sieg - P Geerling - G Kosmehl - H | 2000 | SO: Plast - Reconstr - Surg2000，106，3： | 1 |
| 8 | New aspects of boar se- men freezing strategies 显示文摘 | Grobfeld R Sieg B Struckmann C | 2008 | Theriogenology2008，70，： | 1 |
| 9 | Hemimegalencephaly and linear nevus sebaceous syndrome显示文摘 | Herman TE Siege MJ | 2001 | J Perinatol2001，21，5： | 1 |
| 10 | Signaling through focal adhesion Kinase显示文摘 | Schlaepfer DD Hauck CR Sieg DJ | 1999 | Prog Biophys Mol Bio11999，71，34： | 1 |
| 11 | Vacuum-assisted closure for Radiation assoc iated wound complications 显示文摘 | Siege 1H J Long JL Watson KM | 2007 | J Surg Oncol2007，96，7： | 1 |
| 12 | Clinical profile of single- agent oprozomib in patients with multiple myeloma (MM): Updated results frum a muhicenter, open-Label, dose escalation phase lh / 2 study 显示文摘 | Ravi Vij MBBS Savona M Siege DS et at | 2014 | Bl x d ( ASH annual meeting Abstracts )2014，124，21： | 1 |
| 13 | FAK integrates growth factor and integrin signals to promote cell migration显示文摘 | Sieg D J Hauck C R Ilic D | 2000 | Nat Cell Biol2000，2，5： | 1 |
| 14 | Sebaceous carcinoma of the eyelids-case reports and review of the literature显示文摘 | WARNECKE K K SIEG P | 2006 | Klin Monatsbl Augenheilkd2006，223，9： | 1 |
| 15 | Microvascular submandibular gland transfer for severe cases of keratoconjunctivitis sicca 显示文摘 | Geerling G Kosmehl H | 2000 | Plast Reconstr Surg2000，106，3： | 1 |
| 16 | Henoch-Schonlein syndrome in children:gastrointestinal manifestations显示文摘 | Glasier CM Siege MJ McAliste WH | 1981 | AJR1981，136，6： | 1 |
| 17 | The red cell immune system显示文摘 | Siege I Liu T L Gleicher V | 1981 | Lancet1981，2，： | 1 |
| 18 | Altered expression of cell-cell adhesion molecules 13 eatenin/E cadherin and related Wnt signaling pathway in sporadic and syndromal keratocystic odontogenic tumors 显示文摘 | Hakim SG Kosmehl H Sieg P | 2011 | Clin Oral Investig2011，15，3： | 1 |
| 19 | Radiation does and imagequality in pediatric CT:effect of technical factors and phantom sizeshape显示文摘 | Siege M J Schmidt B Bradley D | 2004 | Radiology2004，235，： | 1 |
| 20 | Viral regulation of CD95 expression and apoptosis in T lymphocytes显示文摘 | Sieg S Huang Y Kaplan D | 1997 | J Immunol1997，259，3： | 1 |
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