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| 1 | Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review显示文摘AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease(NAFLD) onset, severity, and outcome through systematic literature review. METHODS: The authors conducted both systematic and specific searches of Pub Med through December 2015 with special emphasis on more recent data(from 2012 onward) while still drawing from more historical data for background. We identified several specific genetic polymorphisms that have been most researched and, at this time, appear to have the greatest clinical significance on NAFLD and similar hepatic diseases. These were further investigated to assess their specific effects on disease onset and progression and the mechanisms by which these effects occur. RESULTS: We focus particularly on genetic polymorphisms of the following genes: PNPLA3, particularly the p. I148 M variant, TM6SF2, particularly the p. E167 K variant, and on variants in FTO, LIPA, IFNλ4, and iron metabolism, specifically focusing on HFE, and HMOX-1. We discuss the effect of these genetic variations and their resultant protein variants on the onset of fatty liver disease and its severity, including the effect on likelihood of progression to cirrhosis and hepatocellular carcinoma. While our principal focus is on NAFLD, we also discuss briefly effects of some of the variants on development and severity of other hepatic diseases, including hepatitis C and alcoholic liver disease. These results are briefly discussed in terms of clinical application and future potential for personalized medicine. CONCLUSION: Polymorphisms and genetic factors of several genes contribute to NAFLD and its end results. These genes hold keys to future improvements in diagnosis and management. | Tyler J Severson Siddesh Besur Herbert L Bonkovsky | 2016 | World Journal of Gastroenterology2016，22，29： | 12 |
| 2 | Comparision of efficacy of sufentanil and fentanyl with low-concentration bupiva- caine for combined spinal epidural labour analgesia 显示文摘 | AKKAMAHADEVI P SRINIVAS H SIDDESH A | 2012 | Indian J Anaesth2012，56，4： | 1 |
| 3 | Compari- sion of efficacy of sufentanil and fentanyl with low - con- centration bupivaeaine for combined spinal epidural labour analgesia 显示文摘 | Akkamahadevi P Srinivas HT Siddesh A | 2012 | Ind J Anaesthes2012，56，4： | 1 |
| 4 | Effect of prophylactic trochanteric epiph-yseodesis in older children with perthes'disease显示文摘 | Shah H Orth MS Siddesh ND | 2009 | J Pediatr Orthop2009，29，： | 1 |
| 5 | Platelet-specific collagen receptor glycoprotein VI gene variants affect recurrent pregnancy loss显示文摘 | Siddesh A Parveen F1Misra M K5 | 2014 | Fertil Steril2014，102，4： | 1 |
| 6 | Compari- sion of efficacy of sufentanil and fentanyl with low-con- centration bupivacaine for combined spinal epidural labour analgesia 显示文摘 | Akkamahadevi P Srinivas H Siddesh A | 2012 | Indian J Anaesth2012，56，4： | 1 |
| 7 | Donor site morbidity fol-lowing the harvesting of cortical bone graft from the tibia inchildren显示文摘 | Siddesh N Hitesh H Benjamin J | 2010 | J Child Orthop2010，4，5： | 1 |
| 8 | Comparison of efficacy of sufentanil and fentanyl with low-eoneentration bupivacaine for combined spinal epidural labour analgesia 显示文摘 | Akkamabadevi P Srinivas H Siddesh A | 2012 | Indian J Anaesth2012，56，4： | 1 |
| 9 | Comparision of efficacy of sufentanil and fentanyl with low- concentration bupivacaine for combined spinal epidural labour analgesia显示文摘 | Akkamahadevi P Srinivas HT Siddesh A | | 0，，04： | 1 |
| 10 | Comparision of efficacy of sufentanil and fentanyl with low-concentration bupivacaine for combined spinal epidural labour analgesia显示文摘 | Akkamahadevi P Srinivas H Siddesh A | 2012 | Indian J Anaesth2012，56，4： | 1 |
| 11 | Effect of prophylactic trochanteric epiphyseodesis in older children with Perthes disease显示文摘 | Shah H Siddesh ND Joseph B | | 0，，08： | 1 |
| 12 | Comparision of efficacy of sufentanil and fentanyl with low -concentration bupivacaine for combined spinal epidural labour analgesia 显示文摘 | Akkamabadevi P Srinivas H Siddesh A | 2012 | Indian J Anaesth2012，56，4： | 1 |
| 13 | Follicular dendritic cell tumor of mesentery-a case report显示文摘 | Devi S Sunila Siddesh G | | 0，，03： | 1 |
| 14 | Analysis on Factors Causing Project Delays in Road and Highways Sector in India Using Relative Ranking Index Technique显示文摘On-time completion of road infrastructure projects is a critical goal.When projects were not completed on schedule and real construction progress is slower than expected,the inconvenience and disruption to business access increases.On time completion is linked to economic and social welfare,as well as safety.Construction delays continue to be a typical occurrence,despite the need of prompt completion.A literature study is conducted in this context in order to learn more about the causes and factors that contribute to delays.Following a thorough review of the literature,it was determined that a questionnaire survey is the most effective and trustworthy way for gathering information about the causes and quantifying delays caused by emergent factors.The Relative Importance Index(RII)method was used to analyze the data,and the reasons for the delay were prioritized according to their importance.This study focuses on the emergent concerns/causes and reasons of concern in road infrastructure projects,as well as how to priorities these issues sequentially during the planning stage.This study survey can assist construction companies doing business in India in understanding the essential or sensitive issues that require special attention in order to conduct their businesses smoothly in this country while employing appropriate project management practices. | Siddesh K.Pai Neeraj Anand Ankur Mittal | 2021 | Journal of Construction Research2021，3，2： | 0 |
| 15 | Time and Cost Planning of a Housing Construction Project Using Building Information Modelling显示文摘Conventional ways of building construction process lack proper task scheduling and planning of the project work at the site resulting in poor monitoring of the whole process.Building information modelling(BIM)creates a platform where all the information of every single element of the construction process can be virtually integrated.The integration of 3D elements of a building model with its scheduled time and cost parameters results in 5D BIM.This feature enables the visualization,scheduling,planning,and monitoring and clash detection of all pre-construction,construction and post-construction processes of a building.The present study used the information of a live project of a traditionally built residential building which was remodeled using 5D BIM technique.The purpose of this study was to compare and analyses the impact of 5D BIM on time and cost parameters of the live project. | Amit Shriwas Siddesh Pai | 2019 | Journal of Construction Research2019，1，2： | 0 |
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