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| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet显示文摘AIM: To determine the fasting plasma carnitine ester in patients with celiac disease.METHODS: We determined the fasting plasma carnitine ester profile using ESI triple quadrupol mass spectrometry in 33 adult patients with biopsy-confirmed maturity onset celiac disease maintained on long term gluten free diet.RESULIS: The level of free camitine did not differ as the celiac disease patients were compared with the healthy controls, whereas the acetylcarnitine level was markedly reduced (4.703 ± 0.205 vs 10.227 ± 0.368 nmol/mL,P<0.01). The level of propionylcarnitine was 61.5%,butyrylcarnitine 56.9%, hexanoylcarnitine 75%,octanoylcarnitine 71.1%, octenoylcarnitine 52.1%,decanoylcarnitine 73.1%, cecenoylcarnitine 58.3%,lauroylcarnitine 61.5%, miristoylcarnitine 66.7%,miristoleylcarnitine 62.5% and oleylcarnitine 81.1%in the celiac disease patients compared to the control values, respectively (P<0.01).CONCLUSION: The marked decrease of circulating acetylcarnitine with 50-80 % decrease of 11 other carnitine esters shows that the carnitine ester metabolism can be influenced even in clinically asymptomatic and well being adult celiac disease patients, and gluten withdrawal alone does not necessarily normalize all elements of the disturbed carnitine homeostasis. | Judit Bene Katalin Komlósi Beáta Gasztonyi Márk Juhász Zsolt Tulassay Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，42： | 5 |
| 3 | Stem cell therapy as an emerging paradigm for stroke ( STEPS) Ⅱ显示文摘Cell-based therapies represent a new therapeutic approach for stroke.In 2007,investigators from academia,industry leaders,and members of the National Institutes of Health crafted recommendations to facilitate the | Savitz SI Chopp M Deans R Carmichael ST Phinney D Wechsler L | 2011 | 中华神经外科疾病研究杂志2011，10，3： | 5 |
| 4 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 5 | Effect of dispersant concentration on slip casting of cordierite-based glass ceramics 显示文摘 | MEI Si YANG J FERREIRA M F | 2001 | J Colloid Interface Sci2001，241，： | 2 |
| 6 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 7 | Curcunain mediates presenilin- 1 activity to reduce 13-amyloid production in a model of Alzheimer's Disease显示文摘 | ZHANG X ZHANG H M SI L | 2011 | Pharmacological Reports2011，63，5： | 1 |
| 8 | Systemically injected exo- somes targeted to EGFR deliver antitumor microRNA to breast cancer cells显示文摘 | Ohno SI Takanashi M Sudo K | 2013 | Mol Ther2013，21，1： | 1 |
| 9 | Fabrication of highly porous bi- odegradable monoliths strengthened by graphene oxide and their adsorption of metal ions 显示文摘 | Zhang N N Qiu H X Si Y M | 2011 | Carbon2011，49，3： | 1 |
| 10 | The distribution of vascular endothelial growth factor-producing ceils in clinical radiation necrosis of the brain : pathological consideration of their potential roles 显示文摘 | Nonoguchi N Miyatake SI Fukumoto M | 2011 | J Neurooneo12011，105，2： | 1 |
| 11 | Immunity,inflammation,and cancer显示文摘 | Grivennikov SI Greten FR Karin M | | 0，，06： | 1 |
| 12 | Sorbitol dehydrogenase over-expression potentiates glucose toxicity to cultured retinal pericytes显示文摘 | Amano S Yamagishi SI Kato N Inagaku Y Okamoto T Makino M | 2002 | Bio Biophy Res Commun2002，299，2： | 1 |
| 13 | Association of depression with acvers cardiovascular events after percutaneous coronary intervention显示文摘 | Wan ZJ Gu~ M Si TM | 2013 | Coron Artery Dis2013，24，7： | 1 |
| 14 | Understanding individual human mobility patterns显示文摘 | Gonzá lez M C Hidalgo C A Barabá si A L | 2008 | Nature2008，453，7196： | 1 |
| 15 | External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing 显示文摘 | Chakraborty M Abrams SI Coleman CN | 2004 | Cancer Res2004，1564，12： | 1 |
| 16 | Reversible converson of nitroxyl anion to nitric oxide by superoxide dismutase显示文摘 | MURPHY M E SIES H | 1991 | Proc Natl Acad Sci USA1991，88，10： | 1 |
| 17 | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone de acetylase显示文摘 | IMAI SI ARMSTRONG CM KAEBERLEIN M | 2000 | Nature2000，403，6771： | 1 |
| 18 | Dual functionality of BODIPY chromophore in porphyrin-sensitized nanocrystalline solar cells显示文摘 | Shrestha M Si L Chang C | 2012 | J Phys Chem C2012，116，10： | 1 |
| 19 | Meeting the 60-min physical activity guideline:effect of operationalization显示文摘 | De Vries SI Hopman-Rock M Bakker I | | 0，，01： | 1 |
| 20 | Is an elongated stylohyoid process prevalent in theelderly? A radiographic study in a Brazilian population显示文摘 | Rizzatti-Barbosa C M Ribeiro M C Si lva-Concilio L R | 2005 | Gerodontology2005，22，2： | 1 |
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