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| 1 | Sodium Alginate/Carboxyl-Functionalized Graphene Composite Hydrogel Via Neodymium Ions Coordination显示文摘A facile method for the preparation of sodium alginate(SA)/carboxyl-functionalized graphene(G-COOH)composite hydrogel was developed. Based on the coordination ability of lanthanide ions to the carboxyl groups, a series of hydrogel derived from different ratios of SA and G-COOH was fabricated by neodymium(Nd^(3+)) ions coordination. A relatively uniform layered structure was recorded by SEM at the interior of SA/G-COOH hydrogel. Several parameters such as water content, swelling ratio(SR), tensile test and solvent resistance were also investigated. The SA/G-COOH composite hydrogel showed excellent mechanical strength, and the tensile strength of SA/G-COOH composite hydrogel reaches 53.72 MPa at high water content. Due to the coordination ability of Nd^(3+) ions, the hydrogel also exhibited an excellent solvent resistance and stability. | Qianqian Huang Shunli Liu Kewen Li Imtiaz Hussain Fang Yao Guodong Fu | 2017 | Journal of Materials Science & Technology2017，33，8： | 4 |
| 2 | Nanoparticle‑Loaded Polarized‑Macrophages for Enhanced Tumor Targeting and Cell‑Chemotherapy显示文摘Cell therapy is a promising strategy for cancer therapy.However,its therapeutic efficiency remains limited due to the complex and immunosuppressive nature of tumor microenvironments.In this study,the“cell-chemotherapy”strategy was presented to enhance antitumor efficacy.M1-type macrophages,which are therapeutic immune cells with both of immunotherapeutic ability and targeting ability,carried sorafenib(SF)-loaded lipid nanoparticles(M1/SLNPs)were developed.M1-type macrophages were used both as therapeutic tool to provide immunotherapy and as delivery vessel to target deliver SF to tumor tissues for chemotherapy simultaneously.M1-type macrophages were obtained by polarizing macrophages using lipopolysaccharide,and M1/SLNPs were obtained by incubating M1-type macrophages with SLNP.Tumor accumulation of M1/SLNP was increased compared with SLNP(p<0.01),which proved M1/SLNP could enhance tumor targeting of SF.An increased ratio of M1-type macrophages to M2-type macrophages,and the CD3^+CD4^+T cells and CD3^+CD8^+T cell quantities in tumor tissues after treatment with M1/SLNP indicated M1/SLNP could relieve the immunosuppressive tumor microenvironments.The tumor volumes in the M1/SLNP group were significantly smaller than those in the SLNP group(p<0.01),indicating M1/SLNP exhibited enhanced antitumor efficacy.Consequently,M1/SLNP showed great potential as a novel cellchemotherapeutic strategy combining both cell therapy and targeting chemotherapy. | Teng Hou Tianqi Wang Weiwei Mu Rui Yang Shuang Liang Zipeng Zhang Shunli Fu Tong Gao Yongjun Liu Na Zhang | 2021 | Nano-Micro Letters2021，13，1： | 1 |
| 3 | Application of Nano-Delivery Systems in Lymph Nodes for Tumor Immunotherapy显示文摘Immunotherapy has become a promising research“hotspot”in cancer treatment.“Soldier”immune cells are not uniform throughout the body;they accumulate mostly in the immune organs such as the spleen and lymph nodes(LNs),etc.The unique structure of LNs provides the microenvironment suitable for the survival,activation,and proliferation of multiple types of immune cells.LNs play an important role in both the initiation of adaptive immunity and the generation of durable anti-tumor responses.Antigens taken up by antigen-presenting cells in peripheral tissues need to migrate with lymphatic fluid to LNs to activate the lymphocytes therein.Meanwhile,the accumulation and retaining of many immune functional compounds in LNs enhance their efficacy significantly.Therefore,LNs have become a key target for tumor immunotherapy.Unfortunately,the nonspecific distribution of the immune drugs in vivo greatly limits the activation and proliferation of immune cells,which leads to unsatisfactory anti-tumor effects.The efficient nano-delivery system to LNs is an effective strategy to maximize the efficacy of immune drugs.Nano-delivery systems have shown beneficial in improving biodistribution and enhancing accumulation in lymphoid tissues,exhibiting powerful and promising prospects for achieving effective delivery to LNs.Herein,the physiological structure and the delivery barriers of LNs were summarized and the factors affecting LNs accumulation were discussed thoroughly.Moreover,developments in nano-delivery systems were reviewed and the transformation prospects of LNs targeting nanocarriers were summarized and discussed. | Yiming Xia Shunli Fu Qingping Ma Yongjun Liu Na Zhang | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 4 | The preoperative neutrophil-to-lymphocyte ratio predicts the outcomes of patients with hepatocellular carcinoma and cirrhosis after hepatectomy显示文摘Objective The aim of the study was to investigate the prognostic value of the preoperative peripheral neutrophil-to-lymphocyte ratio(NLR) in patients with hepatocellular cancer(HCC) and cirrhosis after hepatectomy. Methods This retrospective study included 321 patients with HCC who underwent resection. The NLR was calculated using the neutrophil and lymphocyte counts in routine preoperative blood tests. Receiver operating characteristic curve analysis was performed to select the most appropriate NLR cutoff value. The preoperative NLR, patient demographics, and clinical and pathological data, including disease-free survival(DFS) and overall survival(OS), were analyzed. Results The NLR was correlated with alpha-fetoprotein levels(χ2 = 5.876, P = 0.015), tumor size(χ2 = 32.046, P < 0.001), portal vein tumor thrombus(PVTT; χ2 = 4.930, P = 0.026), tumor encapsulation(χ2 = 7.243, P = 0.007), and recurrence(χ2 = 7.717, P = 0.005). Multivariate analyses illustrated that the number of tumors, PVTT, tumor size, and the NLR were independent factors for predicting DFS and OS. In patients with HCC and cirrhosis, but not among those without cirrhosis, a larger NLR predicted poorer postoperative DFS and OS(both P < 0.001). Conclusion As a simple, effective independent predictor for patients with HCC, the preoperative NLR plays an important role in accurately predicting the postoperative outcomes of patients with HCC and cirrhosis, but not those of patients without cirrhosis. | Yunpeng Hua Fei Ji Shunjun Fu Shunli Shen Shaoqiang Li Lijian Liang Baogan Peng | 2015 | Oncology and Translational Medicine2015，1，6： | 1 |
| 5 | Micro/nanomotor: A promising drug delivery system for cancer therapy显示文摘Micro/nanomotors(MNMs)are small-scale devices that can effectively convert various forms of energy into mechanical motion.Their controllable motility and good permeability have attracted the interest of researchers as promising drug carriers in cancer therapy.Compared with traditional formulations,micro/nanomotor drug delivery systems can greatly improve therapeutic efficiency and reduce the side effects of antitumor drugs.This review mainly discusses the advantages of micro/nanomotor drug delivery systems and the applications of MNMs propelled by exogenous,endogenous,and biohybrid power in cancer therapy.Finally,the main challenges of the applications of micro/nanomotor drug delivery systems,as well as future development trends and opportunities are discussed. | Weihan Zhang Zipeng Zhang Shunli Fu Qingping Ma Yongjun Liu Na Zhang | 2023 | ChemPhysMater2023，2，2： | 0 |
| 6 | Classification of mass-transport complexes and distribution of gashydrate-bearing sediments in the northeastern continental slope of the South China Sea显示文摘The drilling areas in Shenhu and Dongsha,South China Sea,studied from 2007 to 2015,reveal great heterogeneity in the spatial distribution of the gas hydrate reservoir.Various types of mass-transport complexes(MTCs)were developed in the study areas,which served as ideal reservoirs.To conduct exploration in these areas,it is necessary to study the different types of MTCs and the corresponding gashydrate accumulations.By integrating seismic reflection and log coring data,we classified three types of MTCs according to their stress distribution:the tension,extrusion,and shear types,and their corresponding gashydrate accumulation patterns.The results show that the accumulation of the gas-hydrate varies with the type of MTC and stress distribution depending on the MTC’s position(e.g.,in the headwall,translational,or toe areas).Owing to this variance of the MTC’s position,the corresponding kinemics situation in the MTCs also varies.Accordingly,we determined the corresponding location in which the gashydrate develops for various types of MTCs.Based on the bottom simulating reflectors(BSRs)and the hydrate core and image logging data,the gashydrate reservoir shows an obvious heterogeneity in various types of MTCs.The gashydrate in the tension-type MTCs are mostly borne in the toe and the headwall parts.In extrusion-type MTCs,the translational and toe parts constitute an ideal hydrate reservoir.In shear-type MTCs,the headwall and toe parts’coarse-grained sediments show an obviously hydrate response.After comparing the gashydrate saturation and MTCs morphology statics data,we were able to quantitatively prove that the main factors determining gashydrate accumulation in the different types of MTCs are the fault displacement,sedimentary rate,and flow erosion rate. | Chao FU Xinghe YU Xue FAN Yulin HE Jinqiang LIANG Shunli LI | 2020 | Frontiers of Earth Science2020，14，1： | 0 |
| 7 | Direct pyrolysis to convert biomass to versatile 3D carbon nanotubes/mesoporous carbon architecture:conversion mechanism and electrochemical performance显示文摘The massive conversion of resourceful biomass to carbon nanomaterials not only opens a new avenue to effective and economical disposal of biomass,but provides a possibility to produce highly valued functionalized carbon-based electrodes for energy storage and conversion systems.In this work,biomass is applied to a facile and scalable one-step pyrolysis method to prepare three-dimensional(3D)carbon nanotubes/mesoporous carbon architecture,which uses transition metal inorganic salts and melamine as initial precursors.The role of each employed component is investigated,and the electrochemical performance of the attained product is explored.Each component and precise regulation of their dosage is proven to be the key to successful conversion of biomass to the desired carbon nanomaterials.Owing to the unique 3D architecture and integration of individual merits of carbon nanotubes and mesoporous carbon,the as-synthesized carbon nanotubes/mesoporous carbon hybrid exhibits versatile application toward lithium-ion batteries and Zn-air batteries.Apparently,a significant guidance on effective conversion of biomass to functionalized carbon nanomaterials can be shown by this work. | Chenxi Xu Shunli Li Zhaohui Hou Liming Yang Wenbin Fu Fujia Wang Yafei Kuang Haihui Zhou Liang Chen | 2023 | Frontiers of Chemical Science and Engineering2023，17，6： | 0 |
| 8 | Gas-blasting nanocapsules to accelerate carboplatin lysosome release and nucleus delivery for prostate cancer treatment显示文摘To improve therapeutic effect and reduce severely side effects of carboplatin(CBP),the gas-generating nanocapsules were developed to accelerate CBP lysosome release and nucleus delivery.CBP/SB-NC was prepared by co-loading CBP and NaHCO 3(SB)in nanocapsules using w/o/w emulsification solvent evaporation.They exhibited vesicle-like spherical morphology,uniform particle size and negative zeta potential.Reaching the tumor site with a relatively high concentration is the first step for CBP delivery and the results showed that CBP/SB-NC could effectively increase drug accumulation at tumor site.After that,the drug delivery carriers need to be internalized into tumor cells and the in vitro cellular uptake ability results showed CBP/SB-NC could be internalized into RM-1 cells more efficient than CBP solution.After internalized by RM-1 cells,the gas-blasting release process was tested in acid environment.It was demonstrated that 5 mg/ml NaHCO 3 was optimal to achieve pH-responsive gas-blasting release.In vitro release results showed that CBP significantly rapid release in acid environment(pH 5.0)compared to neutral pH(pH 7.4)(P<0.05).Meanwhile,TEM and the change of the concentration of H+results exhibited that the explosion of CBP/SB 5-NC was more easily happened in lysosome acid environment(pH 5.0).The blasting release can accelerate CBP lysosome release to cytoplasm.Furthermore,the nucleus delivery results showed CBP/SB 5-NC can promote pH-triggered rapid nucleus delivery.And the results of Pt-DNA adduct assay showed that the binding efficiency between CBP and DNA of CBP/SB 5-NC was higher than CBP solution.At last,in vitro and in vivo anti-tumor efficacy proved that CBP/SB 5-NC could enhance anti-tumor activity for prostate cancer therapy.CBP/SB 5-NC also showed superior safety in vitro and in vivo by hemolysis assay and histopathological study.All of the results demonstrate that CBP/SB 5-NC would be an efficient gas-blasting release formulation to enhance prostate cancer treatment. | Shunli Fu Shuang Liang Dandan Jiang Rui Yang Zipeng Zhang Lili Chang Xinke Zhang Yongjun Liu Na Zhang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，2： | 0 |
| 9 | On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition显示文摘Cancer immunotherapy has become a promising strategy.However,the effectiveness of immunotherapy is restricted in'cold tumors'characterized with insufficient T cells intratumoral infiltration and failed T cells priming.Herein,an on-demand integrated nano-engager(JOT-Lip)was developed to convert cold tumors to hot via'increased DNA damage and dual immune checkpoint inhibition'strategy.JOT-Lip was engineered by co-loading oxaliplatin(Oxa)and JQ1 into liposomes with T-cell immunoglobulin mucin-3 antibodies(Tim-3 mAb)coupled on the liposomal surface by metalloproteinase-2(MMP-2)-sensitive linker.JQ1 inhibited DNA repair to increase DNA damage and immunogenic cell death(ICD)of Oxa,thus promoting T cells intratumoral infiltration.In addition,JQ1 inhibited PD-1/PD-L1 pathway,achieving dual immune checkpoint inhibition combining with Tim-3 mAb,thus effectively promoting T cells priming.It is demonstrated that JOT-Lip not only increased DNA damage and promoted the release of damage-associated molecular patterns(DAMPs),but also enhanced T cells intratumoral infiltration and promoted T cell priming,which successfully converted cold tumors to hot and showed significant anti-tumor and anti-metastasis effects.Collectively,our study provides a rational design of an effective combination regimen and an ideal co-delivery system to convert cold tumors to hot,which holds great potential in clinical cancer chemoimmunotherapy. | Xiaoqing Liu Shuang Liang Xiao Sang Lili Chang Shunli Fu Han Yang Huizhen Yang Yongjun Liu Na Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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