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| 1 | Everolimus and zoledronic acid——a potential synergistic treatment for lung adenocarcinoma bone metastasis显示文摘Non-small-cell 肺癌症(NSCLC ) 经常转移到骨头。zoledronic 酸是到肿瘤,和 everolimus 的 cytostatic,这被知道,为 rapamycin 的哺乳动物的目标的禁止者,能禁止癌症的许多类型。此处,我们在在 vitro 并且在 vivo 对待肺腺癌骨头转移上与 everolimus 独自并且在联合评估了 zoledronic 酸的效果。与 everolimus 在联合与 zoledronic 酸对待的老鼠有更多的 apoptotic 肺癌症房间,更多的房间在 G1/G0 阶段被逮捕。p70S6K 的 phosphorylation 在联合治疗组被禁止。肺癌症房间侵略显著地也在 vitro 与联合治疗在这个组被禁止。骨头原子扫描在联合治疗组与那些相比在控制揭示了更变形的损害。骨头扫描和 X 光线照相术的图象显示那联合治疗显著地减少了骨头转移。中等幸存率建议药联合是 synergistic,它能推迟 NSCLC 骨头转移并且在 vivo 延长幸存。 | Yongfeng Yu Zhengbo Song Shunfang Yang Xiaohua Yang Jie Zhang Shun Lu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 5 |
| 2 | INVESTIGATION OF BUOYANT TRAJECTORY OF THERMAL WAKE BEHIND A SLENDER STREAMLINED HEATED BODY OF REVOLUTION IN STRATIFIED FLUID显示文摘In this paper, the buoyant trajectories of laminar far thermal wakes behind slenderstreamlined heated bodies of revolution in stable stratified fluid have been investigated in theoryand experiment. It has been found that the buoyant trajectories of thermal wakes in stratifiedfluid are different from that in homogeneous fluid. The buoyant trajectories of thermal wakes instratified fluid are wavy. The factors influencing the buoyant trajectories of axisymmetric lami-nar thermal wakes in stratified fluid are Richardson number, Nusselt number and number.The validity of theoretical analysis has been proved by the results of measurements and visualiza-tions. The buoyant trajectories of thermal wakes after underwater bodies can be estimated by re-sults herein presented. | Yang, Li Hua, Shunfang Du, Xianzhi | 1992 | Journal of Hydrodynamics1992，4，2： | 4 |
| 3 | The pinhole SPECT for animal model of bone metastasis with SPC-A-1BM human pulmonary adenocarcinoma bone metastasis cell line显示文摘The study was to investigate the role of pinhole single photon emission computed tomography (SPECT), the human pulmonary adenocarcinoma bone-seeking metastasis cell line SPC-A-1BM was used.These cells form typical osteolytic bone metastases when inoculated into the arterial circulation of NIH-Beige-Nude-XD (BNX) mice via the left ventricle.In order to evaluate the irradiation impact of ^(99m)Tc-MDP versus X-ray on cells growth,we used six groups of SPC-A-1BM cells in our imaging scheme and irradiated by various doses of ^(99m)Tc-MDP (37,74,111, 370,740 MBq) and X-ray(40 kV,2 mA,6 s) respectively.The cell's number of each group was well recorded in different exposure time(4,8,12,24,48,72,96 hours).After that,SPC-A-1BM cells(1×106) were inoculated into the mice via left ventricle.We compared the results obtained with those different doses of ^(99m)Tc-MDP using pinhole SPECT and conventional X-ray skeletal surveys.The data show that the cell-survival number of 111 MBq group has insignificant difference with that of X-ray and the dose is adequate to have an ideal image.Besides,it is important that the chromosome of the cells in the group of 111 MBq showed no irradiation-related damages in our test.These results implied that ^(99m)Tc-MDP pinhole SPECT may provide another way other than conventional X-ray skeletal surveys in detecting bone metastasis of pulmonary adenocarcinoma in BNX mice. | GAO Xiuli YANG Shunfang YU Yongli SHI Meiping ZHAO Lanxiang YE Jianding LU Jianying | 2008 | Nuclear Science and Techniques2008，19，5： | 1 |
| 4 | Establishment of an experimental human lung adenocarcinoma cell line SPC-A-1BM with high bone metastases potency by 99m Tc-MDP bone scintigraphy显示文摘 | Shunfang Yang Qianggang Dong Ming Yao Meiping Shi Jianding Ye Langxiang Zhao Jianzhong Su Weiyong Gu Wenhui Xie Kankan Wang Yanzhi Du Yao Li Yan Huang | 2009 | Nuclear Medicine and Biology2009，，3： | 1 |
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