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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Transgenic rice expressing a novel phytase-lactoferricin fusion gene to improve phosphorus availability and antibacterial activity显示文摘The developing trends of livestock production are efficiency,safety and sustainability,which face two major challenges:low availability of phytate phosphorus and abuse of antibiotics.As a solution phytases and antimicrobial peptides are applied as feed additives.However,phytases and antimicrobial peptides are susceptible to proteases,costly by fermentation and potential toxic to production hosts.We transformed an optimized phytase-lactoferricin fusion gene PhyLf driven by an endosperm-specific promoter Gt13aP and Bar(bialaphos resistance) gene as a selection maker into rice.The Bar and PhyLf genes were integrated into the rice genome,stably inherited and expressed.Their phosphinothricin acetyl transferase(PAT)protein content oftransgenic plants with glufosinate resistance varied between 50.45-93.39 ugg^(-1).Fusion protein expressed especially in the seeds oftransgenic rice had a summit phytase activity at 32.30Ug^(-1) which increased by 61.71-fold compared to the control/check group(CK) and 7.54-fold compared to un-optimized transgenic plant.The highest inorganic phosphorus(Pi) content of the transgenic seeds reached 13.15 mg g^(-1) increased by 12.77-fold compared to that of CK.Preliminary antibacterial experiments showed that the enterokinase hydrolysate product of fusion protein could inhibit the growth of Escherichia coli DH5a.These results indicated that the protein PhyLf has the potential to increase availability of feed phytate phosphorus,improve consumer's immunity and reduce the use of antibiotics. | WANG Zuo-ping DENG Li-hua WENG Lü-shui DENG Xiang-yang FU Xi-qin XIN Ye-yun XIAO Guo-ying | 2017 | Journal of Integrative Agriculture2017，16，4： | 4 |
| 3 | Compressive behavior of fiber reinforced high-performance concrete subjected to elevated temperatures 显示文摘 | POON C S SHUI Z H LAM L | 2004 | Cement and Concrete Research2004，34，12： | 1 |
| 4 | Neuroprotective effects of brain-derived neurotrophic factor (BONF) on hearing in experimental pneumococcal meningitis 显示文摘 | LI L SHUI QX LI X | 2005 | J Child Neurol2005，20，1： | 1 |
| 5 | Investigation of the conductivity of asphalt concrete containing conductive fillers 显示文摘 | WU S P MO L T SHUI Z H | 2005 | Carbon2005，43，： | 1 |
| 6 | Nonparametric Detection of FM Signals Using Time-frequency Ridge Energy显示文摘 | Shui P L Bao Z Su H T | 2008 | IEEE Trans on SP2008，56，5： | 1 |
| 7 | Instantaneous frequency estimation based on directionally smoothed pseudo-Wigner-Ville distribution bank 显示文摘 | Shui P L Shang H Y Zhao Y B | 2007 | IET Radar Sonar & Navigation2007，4，1： | 1 |
| 8 | Subband ANMF detection of moving tar- gets in sea clutter 显示文摘 | P L Shui Y L Shi | 2012 | IEEE Transactions on Aerospace and Electronic Systems2012，48，4： | 1 |
| 9 | The infra-red and raman spectra of ultra-fine calcite显示文摘 | Yue L Shui M Xu Z | 2001 | Spectroscopy Lett2001，34，6： | 1 |
| 10 | Nickel-foam-supported retieilar CoO-Li20 composite anode materials for lithium ion batteries 显示文摘 | Yu Y Chen C H Shui J L | 2005 | Angewandte Chemic International Edi- tion2005，44，43： | 1 |
| 11 | A New Cumulant Estimator in Multipath Fading Channels for Digital Modulation Classification显示文摘 | Liu P Shui P L | 2014 | IET Communications2014，8，16： | 1 |
| 12 | Safety of intravitreal injection of bevacizumab in rabbit eyes显示文摘 | Feiner L Barr EE Shui YB | 2006 | Retina2006，26，： | 1 |
| 13 | Fast SAR Image Segmentation via Merging Cost with Relative Common Boundary Length Penalty显示文摘 | Shui P L Zhang Z J | 2014 | IEEE Transactions on Geoscience and Remote Sensing2014，52，10： | 1 |
| 14 | Changes in Runx2/Cbfal Expression and Activity during Osteoblastic Differentiation of Human Bone Marrow Stromal Cells显示文摘 | Shui C Spelsberg T C Riggs B L | 2003 | J Bone Miner Res2003，18，： | 1 |
| 15 | The effect of Iopamidol on theological properties of monoglyceride/water system显示文摘 | Shui L L Guo P Z Chen F | 2005 | Colloids and Surf A2005，256，1： | 1 |
| 16 | Influence of moisture states of natural and recycled aggregates on the slump and compressive strength of hardened concrete 显示文摘 | Poon C S Shui Z H Lam L | 2004 | Cement and Concrete Research2004，34，1： | 1 |
| 17 | Exploration of Alnico alloy as a magnetic electrode material for lithium-ion batteries 显示文摘 | Shui J L Zhang S L | 2004 | Electrochem Commun2004，6，： | 1 |
| 18 | Effect of microstructure of ITZ on compressive strength of concrete prepared with recycled aggregates 显示文摘 | Poon C S Shui Z H Lam L | 2004 | Construction and Building Materials2004，18，6： | 1 |
| 19 | Early fatigue damage in carbon fiber composites observed by electrical resistance measurement 显示文摘 | Wang S Shui X Fu X Chung D D L | 1998 | Materials Science1998，33，： | 1 |
| 20 | Investigation of the conductivity of asphalt concrete containing conductive fillers显示文摘 | Wu S P Mo L T Shui Z H | 2005 | Carbon2005，43，7： | 1 |
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