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1Emerging role of deep learning-based artificial intelligence in tumor pathology显示文摘The development of digital pathology and progression of state-of-the-art algorithms for computer vision have led to increasing interest in the use of artificial intelligence(AI),especially deep learning(DL)-based AI,in tumor pathology.The DL-based algorithms have been developed to conduct all kinds of work involved in tumor pathology,including tumor diagnosis,subtyping,grading,staging,and prognostic prediction,as well as the identification of pathological features,biomarkers and genetic changes.The applications of AI in pathology not only contribute to improve diagnostic accuracy and objectivity but also reduce the workload of pathologists and subsequently enable them to spend additional time on high-level decision-making tasks.In addition,AI is useful for pathologists to meet the requirements of precision oncology.However,there are still some challenges relating to the implementation of AI,including the issues of algorithm validation and interpretability,computing systems,the unbelieving attitude of pathologists,clinicians and patients,as well as regulators and reimbursements.Herein,we present an overview on how AI-based approaches could be integrated into the workflow of pathologists and discuss the challenges and perspectives of the implementation of AI in tumor pathology.Yahui Jiang Meng Yang Shuhao Wang Xiangchun Li Yan Sun 2020Cancer Communications2020,40,4:15
2Isolation and identification of stem cells from degenerated human intervertebral discs and their migration characteristics显示文摘间充质的干细胞(MSC ) 从 intervertebral 圆盘的三个部件独立被孤立并且识别,即体环 fibrosus (AF ) ,原子核 pulposus (NP ) ,和软骨终板(CEP ) 。然而,很少研究被执行了比较这些三种干细胞的性质,他们为他们的潜在的临床的应用程序必要的特别移植能力。在这研究,分别地, MSC 人的堕落磁盘从 AF, NP,和 CEP 被孤立并且在经过 3 点由表面标记和 multilineage 区别试金识别了。干细胞的这三种类型作为 AF-MSCs, NP-MSCs,和 CEP-MSCs 被说出。然后,他们的生物特征以增长,经过,殖民地形成,移植,和侵略能力被比较。结果证明房间的所有三种类型作为 MSC 被识别并且在增长,经过,和殖民地形成能力有类似的特征。当 NP-MSCs 显示出最低迁居能力时, CEP-MSCs 显示出最高的迁居和侵略力量,建议那 CEP-MSCs 并且几乎,没有侵略力量有移植和侵略的最强大的性质什么时候与 AF-MSCs 和 NP-MSCs 相比。比的, CXCR4 的表示才在 CEP-MSCs 是更高的在。Shuhao Liu Haifeng Liang Soo-min Lee Zheng Li Jian Zhang Qinming Fei 2017Acta Biochimica et Biophysica Sinica2017,49,2:10
3Spatial prediction of landslide susceptibility using GIS-based statistical and machine learning models in Wanzhou County,Three Gorges Reservoir, China显示文摘Landslide susceptibility mapping is vital for landslide risk management and urban planning.In this study,we used three statistical models[frequency ratio,certainty factor and index of entropy(IOE)]and a machine learning model[random forest(RF)]for landslide susceptibility mapping in Wanzhou County,China.First,a landslide inventory map was prepared using earlier geotechnical investigation reports,aerial images,and field surveys.Then,the redundant factors were excluded from the initial fourteen landslide causal factors via factor correlation analysis.To determine the most effective causal factors,landslide susceptibility evaluations were performed based on four cases with different combinations of factors('cases').In the analysis,465(70%)landslide locations were randomly selected for model training,and 200(30%)landslide locations were selected for verification.The results showed that case 3 produced the best performance for the statistical models and that case 2 produced the best performance for the RF model.Finally,the receiver operating characteristic(ROC)curve was used to verify the accuracy of each model's results for its respective optimal case.The ROC curve analysis showed that the machine learning model performed better than the other three models,and among the three statistical models,the IOE model with weight coefficients was superior.Ting Xiao Kunlong Yin Tianlu Yao Shuhao Liu 2019Acta Geochimica2019,38,5:8
4Grassland tenure,livelihood assets and pastoralists’resilience:evidence and empirical analyses from western China显示文摘Pastoralists in western China are highly vulnerable due to harsh natural conditions and the poor socioeconomic environment they confront.More than 50%of the pastoralists in major grassland areas are living below the survival line;moreover,around 90%of the usable grasslands in China have been degraded to some degree,and the degradation expands at a rate of two million ha per year.Enhancing pastoralists’resilience is desirable for the economic development and social stability in pastoral areas.As an important aspect influencing livelihoods,grassland tenure in China has not been well studied to learn how it affects the welfare of pastoralists,and what can be done to strengthen their resilience.Based on the evidence from four periods of fieldwork conducted by the authors during 2005-2014,the study applies an analytical framework adapted from the sustainable livelihood theory to examine the interactions of grassland tenure,livelihood assets of pastoralists and their resilience.Main findings show that the existing grassland tenure arrangements cause unbalanced and decreased livelihood assets,which in turn reduce the resilience of pastoralists by lowering their capacities of coping with stresses or shocks.Of the policies and measures aiming to enhance the pastoralists’adaptive capacity and ongoing development,building social capital is critical.Developing functional livelihood asset markets such as grassland rental markets and financial markets will also contribute to a more robust livelihood structure.Shuhao Tan Zhongchun Tan 2017Economic and Political Studies2017,5,4:7
5Geochemistry of Pyrite from the Gangcha Gold Deposit, West Qinling Orogen, China: Implications for Ore Genesis显示文摘The Gangcha gold deposit was discovered in 2011 in the Xiahe-Hezuo region, West Qinling Orogen, China. Five types of pyrite have been identified in the ore according to the detailed mineral paragenetic studies. Geochemical data are presented for type I pyrite(py1) rim-core zonation and for the different types of pyrite based on in-situ laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) and electron probe microanalysis(EPMA). The results show that pyrites are characterized with heterogeneous Au concentrations, which indicate that Au occurs mainly as micro-or nano-particle native inclusions. Time-resolved depth profiles demonstrate that As, Co and Ni occur as solid solutions in pyrite, whereas Cu, Pb, Zn and Ag occur mainly as inclusions. Trace element concentrations differ between rims and cores in py1, and the differences also exist within different pyrite types. These differences indicate complex chemical evolution of the ore-forming fluids, and the overall geology, geochronology, and stable isotope and pyrite data suggest that the ore-forming fluids were closely linked to magmatic activity during the Triassic Period in West Qinling orogenic belt.NIE Xiao SHEN Junfeng LIU Haiming DU Baisong WANG Shuhao LI Jie XU Liwei WANG Ran 2017Acta Geologica Sinica(English Edition)2017,91,6:5
6Zinc finger transcription factor Sp7/Osterix acts on bone formation and regulates col10a1a expression in zebrafish显示文摘Sp7/Osterix as a zinc finger transcription factor is expressed specifically in osteoblasts.Embryonic lethality of Sp7 knockout mice,however,has prevented from examining the functions of Sp7 in osteoblast and bone formation in live animals.Here we used TALEN,a versatile genome-editing tool,to generate one zebrafish sp7 mutant line.Homozygous sp7-/- mutant zebrafish are able to survive to adulthood.Alizarin Red staining and Micro-CT analysis showed that sp7-/- larvae and adult fish fail to develop normal opercula,and display curved tail fins and severe craniofacial malformation,while Alcian Blue staining showed no obvious cartilage defects in sp7-/- fish.Quantitative RT-PCR showed that a number of osteoblast markers including spp1,phex,col1 ala,and col1a1 b are significantly down-regulated in sp7-/- fish.Furthermore,col10a1 a,whose ortholog is the cartilage marker in mice,was shown to be a novel downstream gene of Sp7 as an osteoblast marker in zebrafish.Together,these results suggest that Sp7 is required for zebrafish bone development and zebrafish sp7 mutants provide animal models for investigating novel aspects of bone development.Pengfei Niu Zhaomin Zhong Mingyong Wang Guodong Huang Shuhao Xu Yi HOU Yilin Yan Han Wang 2017Science Bulletin2017,62,3:4
7The improved artificial bee colony algorithm for mixed additive and multiplicative random error model and the bootstrap method for its precision estimation显示文摘To solve the complex weight matrix derivative problem when using the weighted least squares method to estimate the parameters of the mixed additive and multiplicative random error model(MAM error model),we use an improved artificial bee colony algorithm without derivative and the bootstrap method to estimate the parameters and evaluate the accuracy of MAM error model.The improved artificial bee colony algorithm can update individuals in multiple dimensions and improve the cooperation ability between individuals by constructing a new search equation based on the idea of quasi-affine transformation.The experimental results show that based on the weighted least squares criterion,the algorithm can get the results consistent with the weighted least squares method without multiple formula derivation.The parameter estimation and accuracy evaluation method based on the bootstrap method can get better parameter estimation and more reasonable accuracy information than existing methods,which provides a new idea for the theory of parameter estimation and accuracy evaluation of the MAM error model.Leyang Wang Shuhao Han 2023Geodesy and Geodynamics2023,14,3:3
8Directional Electromagnetic Interference Shielding Based on Step-Wise Asymmetric Conductive Networks显示文摘Some precision electronics such as signal transmitters need to not only emit effective signal but also be protected from the external electromagnetic(EM)waves.Thus,directional electromagnetic interference(EMI)shielding materials(i.e.,when the EM wave is incident from different sides of the sample,the EMI shielding effectiveness(SE)is rather different)are strongly required;unfortunately,no comprehensive literature report is available on this research field.Herein,Nicoated melamine foams(Ni@MF)were obtained by a facile electroless plating process,and multiwalled carbon nanotube(CNT)papers were prepared via a simple vacuum-assisted self-assembly approach.Then,step-wise asymmetric poly(butylene adipate-co-terephthalate)(PBAT)composites consisting of loose Ni@MF layer and compact CNT layer were successfully fabricated via a facile solution encapsulation approach.The step-wise asymmetric structures and electrical conductivity endow the Ni@MF/CNT/PBAT composites with unprecedented directional EMI shielding performances.When the EM wave is incident from Ni@MF layer or CNT layer,Ni@MF-5/CNT-75/PBAT exhibits the total EMI SE(SET)of 38.3 and 29.5 dB,respectively,which illustrates theΔSET of 8.8 dB.This work opens a new research window for directional EMI shielding composites with step-wise asymmetric structures,which has promising applications in portable electronics and next-generation communication technologies.Bai Xue Yi Li Ziling Cheng Shengdu Yang Lan Xie Shuhao Qin Qiang Zheng 2022Nano-Micro Letters2022,14,1:3
9The dynamic evolution of aggregated lithium dendrites in lithium metal batteries显示文摘Lithium(Li)metal anodes promise an ultrahigh theoretical energy density and low redox potential,thus being the critical energy material for next-generation batteries.Unfortunately,the formation of Li dendrites in Li metal anodes remarkably hinders the practical applications of Li metal anodes.Herein,the dynamic evolution of discrete Li dendrites and aggregated Li dendrites with increasing current densities is visualized by in-situ optical microscopy in conjunction with ex-situ scanning electron microscopy.As revealed by the phase field simulations,the formation of aggregated Li dendrites under high current density is attributed to the locally concentrated electric field rather than the depletion of Li ions.More specifically,the locally concentrated electric field stems from the spatial inhomogeneity on the Li metal surface and will be further enhanced with increasing current densities.Adjusting the above two factors with the help of the constructed phase field model is able to regulate the electrodeposited morphology from aggregated Li dendrites to discrete Li dendrites,and ultimately columnar Li morphology.The methodology and mechanistic understanding established herein give a significant step toward the practical applications of Li metal anodes.Xin Shen Rui Zhang Shuhao Wang Xiang Chen Chuan Zhao Elena Kuzmina Elena Karaseva Vladimir Kolosnitsyn Qiang Zhang 2021Chinese Journal of Chemical Engineering2021,34,9:3
10Optimal Operation of an Integrated Electricity-heat Energy System Considering Flexible Resources Dispatch for Renewable Integration显示文摘Large fluctuations may occur on the energy supply and the load sides when large-scale renewable energies are integrated,leading to great challenges in power systems.The renewable power curtailment is especially numerous in the integrated electricity-heat energy system(IEHES)on account of electricity-heat coupling.The flexible resources(FRs)on both the energy supply and load sides are introduced into the optimal dispatch of the IEHES and further modeled to alleviate the renewable fluctuations in this paper.On the energy supply side,three kinds of FRs based on electricity-heat coordination are modeled and discussed.On the load side,the shiftable electricity demand resource is characterized.On this basis,the solution for FRs participating in IEHES dispatch is given,with goals of maximizing the renewable penetration ratio and lowering operation costs.Two scenarios are performed,and the results indicate that the proposed optimal dispatch strategy can effectively reduce the renewable energy curtailment and improve the flexibility of the IEHES.The contribution degrees of different FRs for renewable integration are also explored.Wei Wang Shuhao Huang Guangming Zhang Jizhen Liu Zhe Chen 2021Journal of Modern Power Systems and Clean Energy2021,9,4:3
11Improved cat swarm optimization for parameter estimation of mixed additive and multiplicative random error model显示文摘To estimate the parameters of the mixed additive and multiplicative(MAM)random error model using the weighted least squares iterative algorithm that requires derivation of the complex weight array,we introduce a derivative-free cat swarm optimization for parameter estimation.We embed the Powell method,which uses conjugate direction acceleration and does not need to derive the objective function,into the original cat swarm optimization to accelerate its convergence speed and search accuracy.We use the ordinary least squares,weighted least squares,original cat swarm optimization,particle swarm algorithm and improved cat swarm optimization to estimate the parameters of the straight-line fitting MAM model with lower nonlinearity and the DEM MAM model with higher nonlinearity,respectively.The experimental results show that the improved cat swarm optimization has faster convergence speed,higher search accuracy,and better stability than the original cat swarm optimization and the particle swarm algorithm.At the same time,the improved cat swarm optimization can obtain results consistent with the weighted least squares method based on the objective function only while avoiding multiple complex weight array derivations.The method in this paper provides a new idea for theoretical research on parameter estimation of MAM error models.Leyang Wang Shuhao Han 2023Geodesy and Geodynamics2023,14,4:2
12Regulating the d band in WS_(2)@NC hierarchical nanospheres for efficient lithium polysulfide conversion in lithium-sulfur batteries显示文摘The performance of lithium-sulfur batteries is deteriorated by the inferior conductivity of sulfur,the shuttle effect of lithium polysulfides(LiPSs),sluggish redox kinetics of polysulfide intermediates and serious volumetric expansion of sulfur.To overcome these challenges,we report a versatile route to prepare multi-functional nanocomposites with tuable hierarchical structure via ammonium hydroxide(NH_(3)·H_(2) O)induced self-assembly.The versatility of the system has been demonstrated that the organization of the hierarchical structure can be regulated by adding different amounts of NH_(3)·H_(2) O,and WS_(2) and Co_(9)S_(8) with nitrogen-doped carbon coating(denoted as WS_(2)@NC and Co_(9)S_(8)@NC)can be prepared by adding different precursor salts.When the as-prepared materials are applied for Li-S batteries,the WS_(2)@NC composite exhibits a reversible capacity of 1107.4 mAh g^(-1) at 0.1 C after 500 cycles and even 728.9 mAh g^(-1) at2 C for 1000 cycles,which is significantly better than the Co_(9)S_(8) counterpart and other reported WS_(2) sulfur hosts.Experimentally,the advantageous performance of WS_(2) could be attributed to its higher surface area and total pore volume,giving rise to the easier access to electrolyte and better ability to buffer the volume change during the charge/discharge process.Theoretically,the density function theory(DFT)calculation reveals that the as-prepared WS_(2) has a higher binding energy towards LiPSs as well as a lower energy barrier for Li^(+)diffusion on the surface than Co_(9)S_(8).More significantly,the density of states(DOS)analysis further confirms that the superior performance is mainly ascribed to the more prominent shifting and the more charge compensation from d band of W than Co,which increase electronic concentration and give more hybridization of d-p orbitals in the Fermi level of the adsorbed Li2 S4 to accelerate the lithium polysulfide interfacial redox and conversion dynamics in WS_(2).By proposing this mechanism,this work sheds new light on the understanding of catalytic conversion of lithium polysulfides at the atomic level and the strategy to develop advanced cathode materials for high-performance lithium-sulfur batteries.Jintao Liu Shuhao Xiaoa Le Chang Long Lai Rui Wu Yong Xiang Xingquan Liu Jun Song Chen 2021Journal of Energy Chemistry2021,30,5:2
13Impacts of Cultivated Land Conversion on Environmental Sustainability and Grain Self-sufficiency in China显示文摘用省的数据,现在的纸在农业和环境上检验栽培陆地变换的影响。谷物生产中心逐渐地向易碎的更多正在移动并且浇少见的区域,这被发现,施加环境上的更多的压力。在 1990 年代在生态系统服务值引起大损失的陆地变换,而是大规模自从 2000,生态的恢复程序被实现了补偿如此的损失。生态的恢复节目与相对低的陆地生产率在区域被集中,而栽培陆地变换通常与相对高的陆地生产率发生在区域。最新栽培的土地,特别在边际地为农业生产在区域适合,比原版栽培土地是可能的有低得多的生产率层次。因为潜在地可耕种的土地的股票是几乎精疲力尽的,中国的谷物自足政策能被保存可耕地的可得到的股票并且以一个持续方法增加它的生产率仅仅维持。Shuhao Tan 2008China & World Economy2008,16,3:2
14Temporal-Spatial Variation of Surface Suspended Matter and Controlling Factors in the Inner Shelf of the East China Sea in Winter显示文摘Based on the observed surface suspended matter in the East China Sea in February 2007 and June 2015, an empirical model was established using L1 b's band 4 data to retrieve surface suspended matter from the Moderate Resolution Imagine Spectroradiometer Terra imagery. The squared correlation coefficient is 0.8358, and the root mean square error is 0.4285 mg L-1. The model reflects the distribution characteristics of surface suspended matter in the inner shelf of the East China Sea. In this paper, the satellite images of the study area were retrieved in January from 2001 to 2015, and the monthly distribution of surface suspended matter were obtained. The inter-annual distribution of the study area is similar, and the concentration of surface suspended matter is higher near the shore than offshore. A large amount of surface suspended matter is transported southeast under the influence of Zhejiang and Fujian coastal current and Taiwan warm current. Only a small amount of surface suspension can reach the Kuroshio area. The surface suspended matter concentration changes obviously near the estuary because of the effect of differences in the flux of the Yangtze River. Meanwhile, winter monsoon, temperature front, El Ni?o events, and other factors affect the distribution of surface suspended matter in 100 m isobath to coastal water but minimally influence the distribution in 100 m isobath to deep sea.MIN Jianxiong LI Guangxue DING Dong QIAO Lulu MA Yanyan YANG Gang ZHANG Yaqi ZHANG Lei LI Shuhao 2019Journal of Ocean University of China2019,18,1:2
15Aerodynamic Performance of a Flapping Foil with Asymmetric Heaving Motion near a Wall显示文摘Xingjian Lin Shuhao Guo Jie Wu Jingwen Nan 2018Journal of Bionic Engineering2018,15,4:2
16Development and Application of a High-Performance Triangular Shell Element and an Explicit Algorithm in OpenSees for Strongly Nonlinear Analysis显示文摘The open-source finite element software,OpenSees,is widely used in the earthquake engineering community.However,the shell elements and explicit algorithm in OpenSees still require further improvements.Therefore,in this work,a triangular shell element,NLDKGT,and an explicit algorithm are proposed and implemented in OpenSees.Specifically,based on the generalized conforming theory and the updated Lagrangian formulation,the proposed NLDKGT element is suitable for problems with complicated boundary conditions and strong nonlinearity.The accuracy and reliability of the NLDKGT element are validated through typical cases.Furthermore,by adopting the leapfrog integration method,an explicit algorithm in OpenSees and a modal damping model are developed.Finally,the stability and efficiency of the proposed shell element and explicit algorithm are validated through the nonlinear time-history analysis of a highrise building.Xinzheng Lu Yuan Tian Chujin Sun Shuhao Zhang 2019Computer Modeling in Engineering & Sciences2019,,9:1
17Characterization of dioxins emissions from two municipal solid waste incinerations in Taiwan显示文摘Chang Moobee Lin Jungjeng Chang Shuhao 2002Atmospheric Environment2002,36,:1
18Self-adaptive step firefly algorithm显示文摘Yu Shuhao Yang Shanlin Su Shoubao 2013Journal of Applied Mathematics2013,,:1
19Land fragmentation and its driving forces in China显示文摘Shuhao Tan Nico Heerink Futian Qu 2006Land Use Policy2006,23,3:1
20Effect of ridge-furrow and plastic-mulching planting patterns on yield formation and water movement of potato in a semi-arid area显示文摘Qin Shuhao Zhang Junlian Dai Hailin 2014Agricultural Water Management2014,131,:1
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