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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Single and joint stress of acetochlor and Pb on three agricultural crops in northeast China显示文摘In order to evaluate ecological risk of agrochemicals in agricultural environment,single and joint toxic effects of an importantherbicide and a typical heavy metal on root elongation of crops were investigated.Seeds of the three crops including wheat(Triticumaestivum),Chinese cabbage(Brassica pekimensis)and soybean(Glycine max)as the main crops in northeast China were exposed toacetochlor as a herbicide and lead(Pb)as a heavy metal using the pot-culture method,and meadow brown soil as one of the main soilsdistributed in northeast China was applied in the investigation.The results indicated that the interactive effects of the two pollutantson root elongation of the three crops were very complicated although they had markedly significant(P<0.01)linear interrelationshipsbased on the regression analyses.When the concentration of added Pb2+reached 200 mg/kg,acetochlor and Pb had an antagonisticeffect on the inhibition of root elongation of the three crops.However,acetochlor and Pb had significantly(P<0.05)synergic effects onthe inhibition of root elongation when concentration of added Pb2+was up to 1000 mg/kg.At the low concentration of added Pb,jointtoxicity of acetochlor and Pb was more dependent on the concentration of Pb.Among the three crops,wheat was the most sensitive tothe toxicity of Pb and Chinese cabbage was the most sensitive to the toxicity of acetochlor. | CHAO Lei ZHOU Qi-xing CHEN SU CUI Shuang WANG Mei-e | 2007 | Journal of Environmental Sciences2007，19，6： | 14 |
| 3 | Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis显示文摘Obeticholic acid(OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus. Here we propose a combinatory therapeutic strategy of OCA and apoptosis inhibitor for combating against liver fibrosis. CCl4-injured mice, D-galactosamine/LPS(GalN/LPS)-treated mice and cycloheximide/TNFα(CHX/TNFα)-treated HepG2 cells were employed to assess the effects of OCA, or together with IDN-6556, an apoptosis inhibitor. OCA treatment significantly inhibited hepatic stellate cell(HSC)activation/proliferation and prevented fibrosis. Elevated bile acid(BA) levels and hepatocyte apoptosis triggered the activation and proliferation of HSCs. OCA treatment reduced BA levels but could not inhibit hepatocellular apoptosis. An enhanced anti-fibrotic effect was observed when OCA was co-administrated with IDN-6556. Our study demonstrated that OCA inhibits HSCs activation/proliferation partially by regulating BA homeostasis and thereby inhibiting activation of HSCs. The findings in this study suggest that combined use of apoptosis inhibitor and OCA at lower dosage represents a novel therapeutic strategy for liver fibrosis. | Jiyu Zhou Ningning Huang Yitong Guo Shuang Cui Chaoliang Ge Qingxian He Xiaojie Pan Guangji Wang Hong Wang Haiping Hao | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 13 |
| 4 | Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function显示文摘BACKGROUND:Triptolide(TPT)is a diterpenoid triepoxide extracted from the Chinese herb Tripterygium wilfordii Hook.F.It exhibits potent immunosuppressive and anti-inflammatory properties.This study was undertaken to investigate its effects on prolongation of islet allograft survival in rodents.Additionally,we investigated whether TPT would be toxic to islet function in vivo.METHODS:We transplanted BALB/c islets to either chemically induced diabetic C57BL/6 mice or spontaneously diabetic nonobese diabetic(NOD)mice.TPT was injected within 2 weeks or continuously,until rejection,in the two combinations.Then, we evaluated the toxicity of TPT on islet function by daily injection to naive BALB/c or diabetic BALB/c that was cured by syngeneic islet transplantation under the kidney capsule.Mice injected with cyclosporine A(CsA)or vehicle served as controls.Intraperitoneal glucose tolerance tests(IPGTTs)performed at 4 and 8 weeks in the na?ve BALB/c group,and at 2,4,6,and 8 weeks in the syngeneic transplanted group.RESULTS:The medium survival time of islets allograft from TPT treated C57BL/6 and NOD recipients were 28.5 days(range 24-30 days,n=10)and 33.0 days(range 15-47 days,n=6), respectively,and they were significantly different from those of the vehicle treated controls,which were 14.0 days(range 13-16 days,n=6)and 5.0 days(range 4-10 days,n=6),respectively(all P<0.0001).The IPGTT demonstrated that there was no difference between the TPT treated and vehicle treated groups, either in the normal or syngeneic transplanted islet BALB/c mice.However,CsA injection impaired islet function in both normal and syngeneic transplanted mice as early as 4 weeks.CONCLUSION:TPT prolonged islets allograft survival in a chemically induced diabetic or an autoimmune diabetic murine model without impairment of islet function. | Xin, Ming-Jun Cui, Shi-Hua Liu, Shuang Sun, Hai-Chen Li, Fei Sun, Jia-Bang Luo, Bin | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 11 |
| 5 | Apatite Fission Track Evidence of Uplift Cooling in the Qiangtang Basin and Constraints on the Tibetan Plateau Uplift显示文摘The Qiangtang basin is located in the central Tibetan Plateau. This basin has an important structural position,and further study of its tectonic and thermal histories has great significance for understanding the evolution of the Tibetan Plateau and the hydrocarbon potential of marine carbonates in the basin. This study focuses on low temperature thermochronology and in particular conducted apatite fission track analysis. Under constraints provided by the geological background,the thermal history in different tectonic units is characterized by the degree of annealing of samples,and the timing of major(uplift-erosion related) cooling episodes is inferred. The cooling history in the Qiangtang basin can be divided into two distinct episodes. The first stage is mainly from the late Early Cretaceous to the Late Cretaceous(69.8 Ma to 108.7 Ma),while the second is mainly from the MiddleLate Eocene to the late Miocene(10.3 Ma to 44.4 Ma). The first cooling episode records the uplift of strata in the central Qiangtang basin caused by continued convergent extrusion after the BangongNujiang ocean closed. The second episode can be further divided into three periods,which are respectively 10.3 Ma,22.6–26.1 Ma and 30.8–44.4 Ma. The late Oligocene-early Miocene(22.6–26.1 Ma) is the main cooling period. The distribution and times of the earlier uplift-related cooling show that the effect of extrusion after the collision between Eurasian plate and India plate obviously influenced the Qiangtang basin at 44.4 Ma. The Qiangtang basin underwent compression and started to be uplifted from the middle-late Eocene to the early Oligocene(45.0–30.8 Ma). Subsequently,a large-scale and intensive uplift process occurred during the late Oligocene to early Miocene(26.1–22.6 Ma) and the basin continued to undergo compression and uplift up to the late Miocene(10.3 Ma). Thus,uplift-erosion in the Qiangtang basin was intensive from 44.5 Ma to about 10 Ma. The timing of cooling in the second episode shows that the uplift of the Qiangtang basin was caused by the strong compression after the collision of the Indian plate and Eurasian plate. On the whole,the new apatite fission-track data from the Qiangtang basin show that the Tibetan Plateau started to extrude and uplift during 45–30.8 Ma. The main period of uplift and formation of the Tibetan Plateau took place about 22.6–26.1 Ma,and uplift and extrusion continued until the late Miocene(10.3 Ma). | REN Zhanli CUI Junping LIU Chiyang LI Tiejun CHEN Gang DOU Shuang TIAN Tao LUO Yating | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 11 |
| 6 | Local and Global Existence of Solutions to Initial Value Problems of Modified Nonlinear Kawahara Equations显示文摘这篇论文被奉献给学习修改非线性的 Kawahara 方程(部分 deriv u )的起始的价值问题/(部分 deriv t )+α (( u^2 部分 deriv u )/( partialderiv x ))+β (((部分 deriv )~ 3 u )/(部分 deriv x^3 ))+γ (((部分 deriv )~ 5 u )/( partialderiv x^5 ))= 0 ,( x , t )∈ R^2 。我们首先为相应线性问题的基本答案建立几 Strichartz 类型估计。然后,我们使用如此的估计证明修改 nonlinearKarahara 方程的起始的值问题的解决方案的存在本地、全球。如果有 s ≥ 1/4 的起始的功能 U_0 (x)∈ H ~ s (R) ,和一个全球答案存在,如果,结果证明一个本地答案存在 s ≥ 2。 | Shuang Ping TAO Shang Bin CUI | 2005 | Acta Mathematica Sinica,English Series2005，21，5： | 10 |
| 7 | Application of ultra-sonication, acid precipitation and membrane filtration for co-recovery of protein and humic acid from sewage sludge显示文摘一个新奇方法被用于共同恢复从为液体化肥和动物的除去的污水污泥的蛋白质和腐殖的酸喂。在污水污泥的蛋白质首先用 ultrasonication 和酸降水的过程被提取,然后腐殖的酸经由膜过滤被恢复。抽取效率是 125.9 mg 腐殖的酸 ???????????????????????? 卓吗? | Liangliang WEI Kun WANG Xiangjuan KONG Guangyi LIU Shuang CUI Qingliang ZHAO Fuyi CUI | 2016 | Frontiers of Environmental Science & Engineering2016，10，2： | 9 |
| 8 | Global Existence of Solutions for the Cauchy Problem of the Kawahara Equation with L^2 Initial Data显示文摘在这份报纸,我们与 L 2 起始的数据学习 Kawahara 方程的 Cauchy 问题的解决之可能性。由研究 Bourgain 空间 X r, s (R 2 ) 与这个方程联系了,如果,我们证明 Kawahara 方程的 Cauchy 问题是局部地可解决的起始的数据属于 H r (R) 并且 ? 1 < r 鈮 ? 0。如果,这结果与全球答案存在的 Kawahara 方程收益的精力能量守恒定律结合了起始的数据属于 L 2 (R) 。关键词 Kawahara 方程 - Cauchy 问题 - 全球答案先生(2000 ) 题目分类 35Q53 - 中国自然科学基础支持的 35Q35 工程(同意 10171111, 10171112 ) | Shang Bin CUI Dong Gao DENG Shuang Ping TAO | 2006 | Acta Mathematica Sinica,English Series2006，22，5： | 9 |
| 9 | Association between large artery stenosis,cerebral small vessel disease and risk of ischemic stroke显示文摘We aimed to assess the associations of large artery stenosis(LAS)and cerebral small vessel disease(CSVD)with the risk of ischemic stroke and to investigate their respective and combined contributions.In the prospective population-based Shunyi Study,1,082 stroke-free participants aged 55.9±9.1 years were included.Participants were followed for incident stroke throughout the study period(2013-2019).Total small vessel disease score was used to measure CSVD burden.Cervico-cerebral large artery stenosis was evaluated via brain magnetic resonance angiography and carotid ultrasound.We estimated the risk of ischemic stroke in relation to LAS and CSVD with Cox regression models.During a mean follow-up of 4.2 years,34 participants(3.1%)experienced at least one ischemic stroke.Severe LAS(≥50% stenosis versus no stenosis:HR=3.27(95%CI:1.31-8.18))and high CSVD burden(total small vessel disease score 2-4 versus 0 point:HR=12.73(4.83-33.53))were associated with increased stroke risk independently.In multivariate models,CSVD burden(7.72%)explained a larger portion of the variation in stroke risk than severity of LAS(3.49%).Our findings identified that both LAS and CSVD were associated with future ischemic stroke in asymptomatic subjects,while those with high CSVD burden deserve more attention in primary prevention of stroke. | Fei Han Ding-Ding Zhang Fei-Fei Zhai Jun Xue Jiang-Tao Zhang Shuang Yan Li-Xin Zhou Jun Ni Ming Yao Meng Yang Ming-Li Li Zheng-Yu Jin Qing Dai Shu-Yang Zhang Li-Ying Cui Yi-Cheng Zhu | 2021 | Science China(Life Sciences)2021，64，9： | 9 |
| 10 | CIVB flashback analysis of hydrogen flame based on azimuthal vorticity at mixing zone exit显示文摘Swirl-premixed combustion systems exhibit potential to meet future regulations on pollution emissions. However, combustion induced vortex breakdown(CIVB) flashback is frequently observed in these systems, especially for high hydrogen content fuel. In this study, a swirl-premixed burner with diverging centerbody was used to investigate CIVB flashback based on azimuthal vorticity at mixing zone exit. Through 2D axisymmetric model, it was found that there was a maximal azimuthal vorticity at mixing zone exit for each equivalence ratio. The physical meaning of these maximal azimuthal vorticity values was the minimally required azimuthal vorticity to trigger CIVB flashback. At the same time, the required azimuthal vorticity declined with the increase of equivalence ratio since turbulent burning velocity started to control flashback. Nevertheless, azimuthal vorticity offered by heat release increased with the increase of equivalence ratio, which promoted flame propagating upstream continually. | TIAN Xiao Jing XING Shuang Xi CUI Yu Feng FANG Ai Bing NIE Chao Qun | 2014 | Science China(Technological Sciences)2014，57，12： | 7 |
| 11 | Current understanding concerning intestinal stem cells显示文摘In mammals, the intestinal epithelium is a tissue that contains two distinct pools of stem cells: active intestinal stem cells and reserve intestinal stem cells. The former are located in the crypt basement membrane and are responsible for maintaining epithelial homeostasis under intact conditions, whereas the latter exhibit the capacity to facilitate epithelial regeneration after injury. These two pools of cells can convert into each other, maintaining their quantitative balance. In terms of the active intestinal stem cells, their development into functional epithelium is precisely controlled by the following signaling pathways: Wnt/β-catenin, Ras/Raf/Mek/Erk/MAPK, Notch and BMP/Smad. However, mutations in some of the key regulator genes associated with these signaling pathways, such as APC, Kras and Smad4, are also highly associated with gut malformations. At this point, clarifying the biological characteristics of intestinal stem cells will increase the feasibility of preventing or treating some intestinal diseases, such as colorectal cancer. Moreover, as preclinical data demonstrate the therapeutic effects of colon stem cells on murine models of experimental colitis, the prospects of stem cell-based regenerative treatments for ulcerous lesions in the gastrointestinal tract will be improved all the same. | Shuang Cui Peng-Yu Chang | 2016 | World Journal of Gastroenterology2016，22，31： | 6 |
| 12 | Local and Global Existence of Solutions to Initial Value Problems of Nonlinear Kaup-Kupershmidt Equations显示文摘这篇论文被奉献给学习nonlinearKaup- Kupershmidt 方程的起始的价值问题在酒吧+ a1 u 上的部分衍生物u/(部分衍生物 t )在酒吧+贝它上的部分衍生物( 2 )u/(部分衍生物 x ( 2 ))部分衍生物( 3 )u/(部分衍生物)在酒吧 x ( 3 )上+鲸鱼群妈在酒吧=上的部分衍生物( 5 )u/(部分衍生物 x ( 5 )) 0 ( x , t ) epsilonR-2 ,并且在酒吧+上的部分衍生物u/(部分衍生物 t )一( 2 )在酒吧上的部分衍生物u/(部分衍生物 x )在酒吧+贝它上的部分衍生物( 2 )u/(部分衍生物 x ( 2 ))部分衍生物( 3 )u/(部分衍生物 x ( 3 ))在酒吧+鲸鱼群妈上在酒吧=上的部分衍生物( 5 )u/(部分衍生物 x ( 5 )) 0 ,( x , t ) epsilon R-2 。为相应线性问题的基本答案的几重要 Strichartz 类型估计被建立。然后,我们使用如此的估计证明非线性的 Kaup-Kupershmidt 方程的起始的价值问题的解决方案的本地、全球的存在。如果,结果证明一个本地解决方案存在起始的函数 u (0 )(x) epsilon H-s (R) ,和 s > 为第一个方程和 s 的 = 5/4 > 为第二个方程的 = 301/108。 | Shuang Ping TAO Shang Bin CUI | 2005 | Acta Mathematica Sinica,English Series2005，21，4： | 6 |
| 13 | Topologically Protected Edge State in Two-Dimensional Su–Schrieffer–Heeger Circuit显示文摘Topological circuits,an exciting feld just emerged over the last two years,have become a very accessible platform for realizing and exploring topological physics,with many of their physical phenomena and potential applications as yet to be discovered.In this work,we design and experimentally demonstrate a topologically nontrivial band structure and the associated topologically protected edge states in an RF circuit,which is composed of a collection of grounded capacitors connected by alternating inductors in the x and y directions,in analogy to the Su–Schriefer–Heeger model.We take full control of the topological invariant(i.e.,Zak phase)as well as the gap width of the band structure by simply tuning the circuit parameters.Excellent agreement is found between the experimental and simulation results,both showing obvious nontrivial edge state that is tightly bound to the circuit boundaries with extreme robustness against various types of defects.Te demonstration of topological properties in circuits provides a convenient and fexible platform for studying topological materials and the possibility for developing fexible circuits with highly robust circuit performance. | Shuo Liu Wenlong Gao Qian Zhang Shaojie Ma Lei Zhang Changxu Liu Yuan Jiang Xiang Tie Jun Cui Shuang Zhang | 2019 | Research2019，，1： | 6 |
| 14 | Intelligent metasurface imager and recognizer显示文摘There is an increasing need to remotely monitor people in daily life using radio-frequency probe signals.However,conventional systems can hardly be deployed in real-world settings since they typically require objects to either deliberately cooperate or carry a wireless active device or identification tag.To accomplish complicated successive tasks using a single device in real time,we propose the simultaneous use of a smart metasurface imager and recognizer,empowered by a network of artificial neural networks(ANNs)for adaptively controlling data flow.Here,three ANNs are employed in an integrated hierarchy,transforming measured microwave data into images of the whole human body,classifying specifically designated spots(hand and chest)within the whole image,and recognizing human hand signs instantly at a Wi-Fi frequency of 2.4 GHz.Instantaneous in situ full-scene imaging and adaptive recognition of hand signs and vital signs of multiple non-cooperative people were experimentally demonstrated.We also show that the proposed intelligent metasurface system works well even when it is passively excited by stray Wi-Fi signals that ubiquitously exist in our daily lives.The reported strategy could open up a new avenue for future smart cities,smart homes,human-device interaction interfaces,health monitoring,and safety screening free of visual privacy issues. | Lianlin Li Ya Shuang Qian Ma Haoyang Li Hanting Zhao Menglin Wei Che Liu Chenglong Hao Cheng-Wei Qiu Tie Jun Cui | 2019 | Light(Science & Applications)2019，8，1： | 5 |
| 15 | Genetic Diversity, Antimicrobial Resistance, and Virulence Genes of Aeromonas Isolates from Clinical Patients, Tap Water Systems, and Food显示文摘Objective This study aimed to evaluate the genetic diversity,virulence,and antimicrobial resistance of Aeromonas isolates from clinical patients,tap water systems,and food.Methods Ninety Aeromonas isolates were obtained from Ma’anshan,Anhui province,China,and subjected to multi-locus sequence typing(MLST)with six housekeeping genes.Their taxonomy was investigated using concatenated gyr B-cpn60 sequences,while their resistance to 12 antibiotics was evaluated.Ten putative virulence factors and several resistance genes were identified by PCR and sequencing.Results The 90 Aeromonas isolates were divided into 84 sequence types,80 of which were novel,indicating high genetic diversity.The Aeromonas isolates were classified into eight different species.PCR assays identified virulence genes in the isolates,with the enterotoxin and hemolysin genes act,aer A,alt,and ast found in 47(52.2%),13(14.4%),22(24.4%),and 12(13.3%)of the isolates,respectively.The majority of the isolates(≥90%)were susceptible to aztreonam,imipenem,cefepime,chloramphenicol,gentamicin,tetracycline,and ciprofloxacin.However,several resistance genes were detected in the isolates,as well as a new mcr-3 variant.Conclusions Sequence type,virulence properties,and antibiotic resistance vary in Aeromonas isolates from clinical patients,tap water systems,and food. | MENG Shuang WANG Yong Lu LIU Chen Geng YANG Jing YUAN Min BAI Xiang Ning JIN Dong LIANG Jun Rong CUI Zhi Gang LI Juan | 2020 | Biomedical and Environmental Sciences2020，33，6： | 5 |
| 16 | Hierarchical coral-like NiMoS nanohybrids as highly efficient bifunctional electrocatalysts for overall urea electrolysis显示文摘Ti 上的新奇层次像珊瑚的 Ni 瞬间硫化物协调(作为 HC-NiMoS/Ti 表示了) 没有任何模板,通过灵巧的热水、随后的硫化过程被综合。这些非宝贵的 HC-NiMoS/Ti 混血儿为切开的基于脲的全面的水作为 bifunctional 催化剂被探索,包括阳极的脲氧进化反应(UOR ) 和 cathodic 氢进化反应(她的) 。由于高度暴露的活跃地点,优秀费用转移能力,和从多部件反应的好 synergistic 效果, HC-NiMoS/Ti 混血儿展出了优异活动和高稳定性,吗并且 1.59 V 的仅仅房间电压被要求交付 10 妈( BTC ) MOF 在 ZnO/graphene 氧化物被合并(去) photocatalytic 系统由? | Xiaoxia Wang Jianmei Wang Xuping Sun Shuang Wei Liang Cui Wenrong Yang Jingquan Liu | 2018 | Nano Research2018，11，2： | 4 |
| 17 | A Novel Parameter Estimation Algorithm for DSSS Signals Based on Compressed Sensing显示文摘A novel parameter estimation algorithm based on Compressed sensing(CS) for the Direct sequences spread spectrum(DSSS) signals in high dynamic environments is proposed. In this algorithm, Fractional Fourier transform(Fr FT) is first employed to estimate Doppler frequency rate, followed by the quadric phase term compensation. The compensation results are divided into several segments with equal length and coherent integration is carried out within each segment respectively. A convex optimization algorithm is applied to estimate the velocity and initial range of the target simultaneously based on the sparsity of target in the code phase domain. The proposed algorithm is capable of overcoming the limitation of Doppler frequency ambiguity and obtaining the accurate parameter estimates without correcting the code phase drift. Simulation results are presented to demonstrate the validity of the proposed algorithm. | WU Shuang TIAN Jing CUI Wei | 2015 | Chinese Journal of Electronics2015，24，2： | 4 |
| 18 | Research Progress on Nitrogen Use and Plant Growth显示文摘The application of nitrogen(N) fertilizers in agriculture has been increasing dramatically since 1970s. However, the over-fertilization causes could cause environmental problems, as well as low N use effi ciency(NUE). Promoting NUE in plants and minimizing the environmental impacts of N fertilizers had been the focus of the current research. We reviewed the importance of N, N metabolism and plant growth, plant N physiology and the molecular aspect of N metabolism in this paper. The future development of N use and NUE of plants was also discussed. | Cui Xin Yan Qing-wei Sun Jia-lin Xiao Shuang Xie Fu-chun Chen Ya-jun | 2014 | Journal of Northeast Agricultural University(English Edition)2014，21，2： | 4 |
| 19 | Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice显示文摘背景 Cathespin-B (cath-B ) 是在癌症的许多类型涉及侵略的疾病功课的重要的解朊的酶。在下的 heteroplastic 的 Cath-B 表示在裸体鼠标的胰腺的癌没被学习。我们在 heteroplastic 的一个模特儿调查了 cath-B 的角色在 BALB/c 裸体 mice.Methods 的胰腺的癌 32 只 six-week-old 女性 BALB/c 裸体老鼠同等地被划分成四个组。PANC-1 房间在左腋的区域皮下地被接种。除卷,下的肿瘤的重量,和在身体重量的变化以外,在每个组的 cath-B 表示被 immunohistochemical 染色, PCR 并且西方的弄污测量。它到 microvessel 密度(MVD ) 的关系, CD44v6,和胎盘生长因素(PLGF ) 也被检验。 CA-074Me , cath-B 的一个特定的禁止者, intraperitoneally 被注射( i.p )在在组 B 和 C.Gemcitabine (宝石)的肿瘤生长的不同阶段,也被注射( i.p )在组,在不同层次把反肿瘤功效与 cath-B 的 CA-074Me.Results 表示作比较的 D 与肿瘤生长有关, MVD ,和 PLGF 表示。在组 A (控制组) , cath-B 表示多于在另外的组看那被提高。CA-074Me 清楚地在组 B 禁止了 cath-B 表示和肿瘤生长。关于有肿瘤的生长和 angiogenesis,然而并非与 CD44v6 导致的粘附的反肿瘤 effect.Conclusions Cath-B 相互关联组 C 和 D 之间没有差别。CA-074Me 清楚地禁止了 cath-B 表示并且示威一反肿瘤并且 anti-angiogenesis 效果。 | ZHANG Chong SUN Jia-bang LIU Da-chuan CUI Ye-qing LIU Shuang SUN Hai-chen | 2009 | Chinese Medical Journal2009，，20： | 4 |
| 20 | Application of medial column classification in treatment of intraarticular calcaneal fractures显示文摘BACKGROUND There are many types of treatments for calcaneal fractures,including conservative treatment,conventional surgical treatment,and minimally invasive surgery.The choice of specific treatment options is still controversial.Open reduction and internal fixation are currently the most commonly used surgical procedures in the clinic.A good fracture reduction effect can be achieved by using the lateral extension incision of the calcaneus;however,many studies have reported a high incidence of postoperative incision complications.Although there are many methods for the classification of intra-articular calcaneal fractures,it is generally believed that the computed tomography(CT)classification proposed by Sanders has high application value in the selection of treatment methods and evaluation of prognosis of calcaneal fractures.However,this method has no clear guiding significance for the choice of surgical incision and surgical plan.AIM To explore the application and clinical efficacy of medial column classification in the treatment of intra-articular calcaneal fractures.METHODS From July 2017 to July 2018,91 patients,including 60 males and 31 females aged 27 to 60 years,were enrolled.All participants had closed intra-articular calcaneal fracture,and their surgical options were selected under the guidance of medial column classification.The patients'fractures were classified according to the Sanders classification:Type II,35 cases;Type III,33 cases;and Type IV,23 cases.Among them,53 patients had medial column displacement(shortened varus)and underwent open reduction and internal fixation with L-lateral incision of the calcaneus;38 patients had no displacement of the medial column and underwent open reduction and internal fixation with tarsal sinus incision.The calcaneus Bohler angle,Gissane angle,length,width,height,and step thickness of the articular surface were evaluated by X-ray and three-dimensional CT before and after surgery and at the last follow-up.Foot function recovery was assessed by the Maryland foot scoring criteria.RESULTS All patients were followed for 5 to 14 mo,with an average of 10.5±2.9 mo.The fractures of all patients healed,and the healing time was 10 to 19 wk,with an average of 10.8±1.5 wk.One patient developed wound infection 1 wk after surgery and was actively debrided and implanted with antibiotic calcium sulfate to control the infection.The patient's fracture healed 5 mo after surgery.One patient developed a sural nerve injury,and the symptoms disappeared 3 mo after surgery.The patients were assessed according to the Maryland foot scoring system:Excellent in 77 cases,good in 10,and fair in 4.The excellent and good rate was 95.6%.CONCLUSION Medial column classification can effectively guide the surgical selection for intraarticular fractures of the calcaneus. | Gang Zheng Fan Xia Shuang Yang Jun Cui | 2020 | World Journal of Clinical Cases2020，8，19： | 4 |
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