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您的检索式：作者名="Shoukui Hu"
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| 1 | Alteration of gut microbiota in type 2 diabetes complicated with cholelithiasis patients显示文摘To the Editor:Type 2 diabetes(T2D)and cholelithiasis are both common diseases with a high,prevalence.In China,the,prevalence of T2D,is.0.90% and that offadult cholelithiasis is 6.83%. | Jiajia Chen Linlin Yan Xingfan Ma Ping Yuan Fan Zhao Zihan Han Jingshan Liu Wenbo Wang Donghai Zhou Hongyu Zhao Nan Feng Dandan Huang Shoukui Hu Jin Gui | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 2 | Association of SOST gene polymorphisms with peak bone mineral density in Chinese nuclear families with male-offspring显示文摘Peak bone mineral density(BMD)achieved during early adulthood is a highly heritable trait and a strong determinant of subsequent osteoporotic fracture risk.Evidence has already suggested that 50–80% of the variance in peak BMD is genetically determined [1].Human SOST gene comprises three exons and two introns,mapping to chromosomal region 17q12–q21.It inhibits osteoblastic bone formation by inhibiting the Wnt signaling pathway,which is critically important for the development and function of osteoblasts [2].Our previous study in large samples of postmenopausal Chinese women showed that the polymorphisms in the SOST gene are associated with BMD of the lumbar spine [3],but little is known in men.Thus,the objective of this study was to investigate whether polymorphisms in the SOST gene are associated with variations of peak BMD in Chinese nuclear families with male-offspring. | Luyue Qi Shoukui Xiang Li Li Jinwei He Wenzhen Fu Yujuan Liu Yunqiu Hu Zhenlin Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 0 |
| 3 | Glucagon-like peptide-1 receptor gene polymorphism is associated with fat mass in Chinese nuclear families with male offspring显示文摘Obesity is a serious and growing worldwide health threat associated with increased risk of Type 2 diabetes,hypertension,dyslipidemia,cardiovascular disease,and several forms of cancers[1].It is a complex disease under strong genetic control,and a number of genetic variants for obesity have been identified[2].However,the identified loci explain only a small proportion of the heritability for obesity,suggesting that more associated variants remain to be discovered.Glucagon-like peptide-1(GLP-1)is a potent glucose-dependent insulinotropic gut hormone that is secreted from enteroendocrine L cells of the terminal ileum.In addition to its insulinotropic effects,GLP-1 prevents fat accumulation through various mechanisms[3].GLP-1 exerts its action through the GLP-1 receptor(GLP-1R)which has a wide tissue distribution including adipose tissue.Previous studies have shown that single-nucleotide polymorphisms(SNPs)in the GLP-1R gene may alter binding affinity for GLP-1 and intracellular signaling after hormone-receptor binding[4,5]. | Shoukui Xiang Luyue Qi Fei Zhao Wenjie Wang Xiaoya Zhang Yunqiu Hu Fei Hua Zhenlin Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 0 |
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