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189篇 您的检索式：作者名="Shoemaker M"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	An investigation of the chemical stability of arsenosugar in simulated gastric juice and acidic environments using IC-ICP-MS and IC-ESIMS/MS显示文摘	GAMBLE B M GALLAGHER P A SHOEMAKER J A	2002	Analyst2002，127，：	1
3	Comparative pharmacokinetics and bioavailability of oxolinic acid in channel catfish (Ictalurus punctatus) and rainbow trout (Oncorhynchus mykiss)显示文摘	Kleinow K M Jarboe H H Shoemaker K E	1994	Can J Fish Aquac Sci1994，51，：	1
4	Journal of Microbiological Methods显示文摘	Donohue M J Smallwood A W Pfaller S Rodgers M Shoemaker J A	2006	65 : 3802006，65，：	1
5	Analysis of a quantitative trait locus allele from wild soybean that increases seed protein concentration in soybean显示文摘	Sebolt A M Shoemaker R C Diers B W	2000	Crop Science2000，40，5：	1
6	Lunar surface topography显示文摘	Rennilson J J Dragg J L Morris E C Shoemaker E M Turkevich A	1966	Surveyor I mission report part Ⅱ:Scientific data and results NASA JPL Technical Report1966，32，：	1
7	Reduced startle gating after D1 blockade: effects of concurrent D2 blockade 显示文摘	Swerdlow NR Shoemaker JM Bongiovanni M J	2005	Pharmacd Biochem Behav2005，82，2：	1
8	Integration of simple sequence repeat DNA markers into a soybean linkage map 显示文摘	Akkaya M S Shoemaker R C Specht J E	1995	Crop Sci1995，35，5：	1
9	Comparative pharmacokinetics and bioavailability of oxolinic acid in channel catfish (Ictalurus punctatus) and rainbow trout (Oncorhynchus mykiss)显示文摘	Kleinow K M Jarboe H H Shoemaker K E	1994	Aquaculture1994，51，：	1
10	The South Pole Region of the Moon as Seen by Clementine显示文摘	Shoemaker E M Robinson M S Eliason E M	1994	Science1994，266，：	1
11	Observations of the lunar regolith and the Earth from the television camera on Surveyor 7显示文摘	Shoemaker E M Batson R M Holt H E Morris E S Rennilson J J Whitaker E A	1969	J Geophys Res1969，74，：	1
12	First natural occurrence of coesite 显示文摘	Chao E C T Shoemaker E M Madsen B M	1960	Science1960，132，：	1
13	Overlapping pheno types of multidrug resistance among panels human cancer cell lines 显示文摘	Izquierdo MA Shoemaker RH Flens M J	1996	Int J Cancer1996，65，2：	1
14	lnleqflmetary Crre- lation of Geologic Time 显示文摘	Shoemaker 1' M tlackman I J lggleton R E	1962	al Astronaut S i1962，8，：	1
15	Graphical methods for assessing logistic regression models显示文摘	Landwehr J M Pregibon D Shoemaker A C	1984	Journal of the Ameri- can Statistical Association1984，79，385：	1
16	Influence of ensemble surrogate models and sampling strategy on the solution quality of algorithms for computationally expensive black-box global optimization problems 显示文摘	Müller J Shoemaker C A	2014	Journal of Global Optimization2014，60，2：	1
17	The economics of heap leaching显示文摘	Shoemaker R S Darrah R M	1968	Mining Engineering1968，20，12：	1
18	In vitro anti- cancer adivity of twelve Chinese medicinal herbs显示文摘	Shoemaker M Hamilton B Dairkee S H	2005	Phytoth- erRes2005，19，7：	1
19	Orbital express space operations architecture program显示文摘	Shoemaker J Wright M		0，，：	1
20	In vitro antican- cer activity of twelve Chinese medicinal herbs显示文摘	Shoemaker M Hamilton B Dairkee S H	2005	Phytotheapyr Research2005，19，7：	1

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