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| 1 | Role of surveillance imaging and endoscopy in colorectal cancer follow-up:Quality over quantity?显示文摘Colorectal cancer(CRC) is a prevalent disease and represents a major cause of morbidity and mortality in the developed world. Intensive post-treatment surveillance is routinely recommended by major expert groups for early stage(Ⅱ and Ⅲ) CRC survivors because previous meta-analyses showed a modest, but significant survival benefit. This practice has been recently challenged based on data emerging from several large phase Ⅲ randomized trials that demonstrated a lack of survival benefit from intensive surveillance strategies. In addition,findings from cost-effectiveness analyses of such an approach are inconsistent.Data on real-world practice, specifically adherence to these follow-up guidelines,are also limited. The debate is especially controversial in resected stage Ⅳ patients where there are currently no clear guidelines for follow-up. In an era of personalized medicine, there may be a shift towards a more risk-adapted approach to better define the optimal follow-up strategy. In this article, we review the evidence and highlight the role of surveillance in CRC survivors. | Shiru L Liu Winson Y Cheung | 2019 | World Journal of Gastroenterology2019，25，1： | 4 |
| 2 | Mutagenesis and selective breeding of a high producing ε-poly-L-lysine strain显示文摘 | Tian WANG Shiru JIA Zhilei TAN Yujie DAI Shuai SONG Guoliang WANG | 2012 | Frontiers of Chemical Science and Engineering2012，6，2： | 3 |
| 3 | Penta-P2X (X=C, Si) monolayers as wide-bandgap semiconductors: A first principles prediction显示文摘 | Mosayeb Naseri Shiru Lin Jaafar Jalilian Jinxing Gu Zhongfang Chen | 2018 | Frontiers of physics2018，13，3： | 3 |
| 4 | Phase Equilibrium and Phase Diagram of the Ternary System(MgCl2 + MgB2O4 + H2O) at 288 and 298 K显示文摘1 Introduction The brines with high concentrations of magnesium and boron resources are widely distributed in the Qaidam Basin of the Qinghai-Tibet plateau,China(Zheng&Tang,1988).Although some works on the ternary | GUO Yafei SUN Shiru GAO Diaolin YU Xiaoping WANG Shiqiang DENG Tianlong | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 2 |
| 5 | Drug resistance in targeted cancer therapies with RAF inhibitors显示文摘Hyperactive RAS/RAF/MEK/ERK signaling has a well-defined role in cancer biology.Targeting this pathway results in complete or partial regression of most cancers.In recent years,cancer genomic studies have revealed that genetic alterations that aberrantly activate the RAS/RAF/MEK/ERK signaling mainly occur on RAF or upstream,which motivated the extensive development of RAF inhibitors for cancer therapy.Currently,the first-generation RAF inhibitors have been approved for treating late-stage cancers with BRAF(V600E)mutations.Although these inhibitors have achieved promising outcomes in clinical treatments,their efficacy is abolished by quick-rising drug resistance.Moreover,cancers with hyperactive RAS exhibit intrinsic resistance to these drugs.To resolve these problems,the second-generation RAF inhibitors have been designed and are undergoing clinical evaluations.Here,we summarize the recent findings from mechanistic studies on RAF inhibitor resistance and discuss the critical issues in the development of next-generation RAF inhibitors with better therapeutic index,which may provide insights for improving targeted cancer therapy with RAF inhibitors. | Ufuk Degirmenci Jiajun Yap Yuen Rong MSim Shiru Qin Jiancheng Hu | 2021 | Cancer Drug Resistance2021，4，3： | 2 |
| 6 | Understanding the“SMART”features of hematopoietic stem cells and beyond显示文摘Since the huge success of bone marrow transplantation technology in clinical practice,hematopoietic stem cells(HSCs)have become the gold standard for defining the properties of adult stem cells(ASCs).Here,we describe the“self-renewal,multilineage differentiation,apoptosis,rest,and trafficking”or“SMART”model,which has been developed based on data derived from studies of HSCs as the most well-characterized stem cell type.Given the potential therapeutic applications of ASCs,we delineate the key characteristics of HSCs using this model and speculate on the physiological relevance of stem cells identified in other tissues.Great strides are being made in understanding the biology of ASCs,and efforts are now underway to develop safe and effective ASC-based therapies in this emerging area. | Shiru Yuan Guohuan Sun Yawen Zhang Fang Dong Hui Cheng Tao Cheng | 2021 | Science China(Life Sciences)2021，64，12： | 2 |
| 7 | Enhancement of Yeast Fermentation by Addition of Oxygen Vectors in Air-Lift Bioreactor显示文摘 | Shiru JIA Minhxia WANG Prihardi KAHAR | 1997 | Journal of fermentation and bioengineering1997，84，2： | 1 |
| 8 | Biosynthesis of spherical Fe3O4 /bacterial cellulose nanocomposites as adsor- bents for heavy metal ions显示文摘 | Zhu Huixia Jia Shiru Wan Tong | 2011 | Carbohydrate Polymers2011，86，4： | 1 |
| 9 | Production of L-phenylalanine from trans-cinnamic acids by high- level expression of phenylalanine ammonia lyase gene from Rhodosporidium toruloides in Escherichia coli显示文摘 | JIA Shiru CUI Jiandong LI Yan | 2008 | Biochemical Engineering Journal2008，42，： | 1 |
| 10 | A novel bacteriocin with a broad inhibitory spectrum produced by Lactobacillus sake C2, isolated from traditional Chinese fermented cabbage 显示文摘 | Yurong Gao Shiru Jia Qiang Gao | 2010 | Food Control2010，21，： | 1 |
| 11 | Novel com-pressive seals for solid oxide fuel cells显示文摘 | Shiru Lea Kening Suna Zhang Naiqing | 2006 | J Power Sources2006，161，： | 1 |
| 12 | Comparison of infiltrated ceramic fiber paper and mica base compressive seals for planar solid oxide fuel cells显示文摘 | Shiru Lea Kening Suna | 2007 | J Power Sources2007，168，： | 1 |
| 13 | The influence of fermentation conditions and post - treatment methods on porosity of bacterial cellulose membrane 显示文摘 | Weihua Tang Shiru Jia Yuanyuan Jia | 2010 | World Journal of Microbiology and Biotechnology2010，26，： | 1 |
| 14 | A novel bacte-riocin with a broad inhibitory spectrum produced by Lacto-bacillus sake C2 , isolated from traditional Chinese fermen-ted cabbage显示文摘 | Yurong Gao Shiru Jia Qiang Gao | 2010 | Food Control2010，21，： | 1 |
| 15 | Characterization and properties of polyethylene blends 2: LLDPE with conventional LDPE 显示文摘 | Kyu T Shiru H Stein R S | 1987 | Polym Sci: Part B Polym phys1987，25，1： | 1 |
| 16 | Enhanced oxygen transfer in tower bioreactor on addition of liquid hydrocarbons 显示文摘 | Shiru Jiaa Pe Lia Yong Soo Parkb | 1996 | Journal of Fermentation and Bioengineering1996，82，2： | 1 |
| 17 | Fractionation and characterization of ?-poly-l-lysine from Streptomyces albulus CGMCC 1986显示文摘 | JIA Shiru FAN Baoqing DAI Yujie | 2010 | Food Science and Biotechnology2010，19，2： | 1 |
| 18 | Effect of solid bed -materials on vegetative cells of Nostoc flagelliforme 显示文摘 | XueFeng Chen ShiRu Jia SiJtm Yue | 2010 | Journal of Applied Phycology2010，22，： | 1 |
| 19 | Novel compressive seals for solid oxide fuel eells显示文摘 | Shiru Le Kening Sun Naiqing Zhang | 2006 | Journal of Power Sources2006，，161： | 1 |
| 20 | Effect of soybean oil on oxygen transfer in the production of tetracycline with an airlift bioreactor显示文摘 | Shiru Jia Guibin Chen Prihardi Kahar Du Bok Choi Mitsuyasu Okabe | 1999 | Journal of Bioscience and Bioengineering1999，，6： | 1 |
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