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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Poly (o-toluidine) coatings on copper electro-chemical syn- thesis from aqueous media 显示文摘 | SHINDE V MANDALE A B PATIL K R | 2006 | Surface & Coatings Technology2006，200，： | 1 |
| 3 | Copper(II) complexes of isonitroso-β-diketones显示文摘 | Babar V J Desai B J Shinde V M | 1983 | J Indian Chem Soc1983，60，： | 1 |
| 4 | Ap- plications of pathology-assisted image analysis of immunohis- tochemistry-based biomarkers in oncology 显示文摘 | SHINDE V BURKE K E CHAKRAVARTY A | 2014 | Vet Pathol2014，51，1： | 1 |
| 5 | Synthesis and characterization of corrosion protective poly ( 2, 5-dimethylaniline) coatings on copper显示文摘 | Shinde V Gaikwad A B Patil P P | 2006 | Appl Surf Sci2006，253，3： | 1 |
| 6 | Damage localisation in composite and metallic structures using a structural neural system and simulated acoustic emissions 显示文摘 | Kirikera G R Shinde V Schulz M J | 2007 | Mechanical Systems and Signal Processing2007，21，1： | 1 |
| 7 | Performance of membraneless microbial fuel cell treating wastewater and effect of electrode distance and area on electricity production显示文摘 | Ghangrekar M M Shinde V B | 2007 | Original Research Article Bioresource Technology2007，98，15： | 1 |
| 8 | Performance of membrane-less microbial fuel cell treating wastewater and effect of electrode distance and area on electricity production显示文摘 | Ghangrekar M M Shinde V B | 2007 | Biaresour Technol2007，98，15： | 1 |
| 9 | Triple-reassortant swine influenza A( H1 ) in humans in the United States 显示文摘 | Shinde V Bridge CB Uyeki TM | 2005 | N Engl J Med2005，360，： | 1 |
| 10 | An extraction study of gallium, indium and thallium using TPHSO as an extractant显示文摘 | Santosh V Vartak Vijay M Shinde | 1998 | Talanta1998，45，： | 1 |
| 11 | Development of CZTS thin films solar cells by pulsed laser deposition:influence of pulse repetition rate显示文摘 | MOHOLKAR A V SHINDE S S BABAR A R | | 0，，07： | 1 |
| 12 | Poly(o-toluidine) coatings on copper: Electrochemical synthe sis from aqueous media显示文摘 | SHINDE V MANDALE A B PATIL K R | 2006 | Surface & Coatings Technology2006，200，： | 1 |
| 13 | Performance of membrane-less microbial fuel cell treating wastewater and effect of electrode distance and area on electricity production 显示文摘 | Ghangrekar M M Shinde V B | 2007 | Bioresource Technology2007，98，15： | 1 |
| 14 | Electrical, optical and structural properties of nanostructured Sb2 S3 thin films deposited by cbd technique显示文摘 | Ubale A U Deshpande V P Shinde Y P | 2010 | Chaleogenide Letters2010，7，1： | 1 |
| 15 | Performance of membrane-less microbial fuel cell treating wastewater and effect of electrode distance and area on electricity production显示文摘 | Ghangrekar M M Shinde V B | 2007 | Bioresource Technology2007，98，15： | 1 |
| 16 | Triple-Reassortant Swine Influenza A (HI) in Humans in the United States, 2005-2009 显示文摘 | Shinde V Bridges C B Uyeki T M | 2009 | N Engl J Med2009，360，25： | 1 |
| 17 | Triple reassortant swine influenza A (H1) in humans in the United States 2005- 2009显示文摘 | Shinde V Bridges C B Uyeki T M | 2009 | N Engl J Med2009，360，25： | 1 |
| 18 | Triple-reassortant swine influenza A (H1N1) in humans in the United States, 2005- 2009 显示文摘 | Shinde V Bridge CB Uyeki TM etal | 2009 | N Engl J Med2009，360，25： | 1 |
| 19 | FPGA based packet splitter implementation using mixed design flow显示文摘 | Shinde S A Shelake V G Kamat R K | 2008 | Electronics and Electrical Engineering2008，8，88： | 1 |
| 20 | Triple-reassortant swine influenza A(H1)in humans in the United States,2005-2009显示文摘 | Shinde V Bridges CB Uyeki TM | 2009 | N Engl J Med2009，360，25： | 1 |
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