|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 2 | Cotton-derived oxygen/sulfur co-doped hard carbon as advanced anode material for potassium-ion batteries显示文摘Hard carbon is regarded as promising anode materials for potassium-ion batteries(KIBs)owing to their low price and easy availability.However,the limited rate capability still needs to be improved.Herein,we demonstrate the fabrication of oxygen/sulfur co-doped hard carbon through a facile hydrolyzationsulfuration process of skimmed cotton.The simultaneous dopants significantly improve potassium ion diffusion rate.When served as the anode for KIBs,this hydrolyzed hard carbon delivered a high reversible capacity(409 mAh/g at 0.1 A/g),superior rate capability(135 mAh/g at 2 A/g)and excellent cyclability(about 120 mAh/g overt 500 cycles at 2 A/g).This work provides a facile strategy to prepare low-cost doped-hard carbon with superior potassium storage property. | Baolin Xu Shihan Qi Fang Li Xiaoxin Peng Jinfeng Cai Jiaojiao Liang Jianmin Ma | 2020 | Chinese Chemical Letters2020，31，1： | 12 |
| 3 | Driving Forces and Their Effects on Water Conservation Services in Forest Ecosystems in China显示文摘Identifying the driving forces that cause changes in forest ecosystem services related to water conservation is essential for the design of interventions that could enhance positive impacts as well as minimizing negative impacts. In this study, we propose an assessment concept framework model for indirect-direct-ecosystem service(IN-DI-ESS) driving forces within this context and method for index construction that considers the selection of a robust and parsimonious variable set. Factor analysis was integrated into two-stage data envelopment analysis(TS-DEA) to determine the driving forces and their effects on water conservation services in forest ecosystems at the provincial scale in China. The results showed the following. 1) Ten indicators with factor scores more than 0.8 were selected as the minimum data set. Four indicators comprising population density, per capita gross domestic product, irrigation efficiency, and per capita food consumption were the indirect driving factors, and six indicators comprising precipitation, farmland into forestry or pasture, forest cover, habitat area, water footprint, and wood extraction were the direct driving forces. 2) Spearman's rank correlation test was performed to compare the overall effectiveness in two periods: stage 1 and stage 2. The calculated coefficients were 0.245, 0.136, and 0.579, respectively, whereas the tabulated value was 0.562. This indicates that the driving forces obviously differed in terms of their contribution to the overall effectiveness and they caused changes in water conservation services in different stages. In terms of the variations in different driving force effects in the years 2000 and 2010, the overall, stage 1, and stage 2 variances were 0.020, 0.065, and 0.079 in 2000, respectively, and 0.018, 0.063, and 0.071 in 2010. This also indicates that heterogeneous driving force effects were obvious in the process during the same period. Identifying the driving forces that affect service changes and evaluating their efficiency have significant policy implications for the management of forest ecosystem services. Advanced effectiveness measures for weak regions could be improved in an appropriate manner. In this study, we showed that factor analysis coupled with TS-DEA based on the IN-DI-ESS framework can increase the parsimony of driving force indicators, as well as interpreting the interactions among indirect and direct driving forces with forest ecosystem water conservation services, and reducing the uncertainty related to the internal consistency during data selection. | GONG Shihan XIAO Yang XIAO Yi ZHANG Lu OUYANG Zhiyun | 2017 | Chinese Geographical Science2017，27，2： | 9 |
| 4 | Development and path planning of a novel unmanned surface vehicle system and its application to exploitation of Qarhan Salt Lake显示文摘Qarhan Salt Lake is rich in mineral resources, such as sodium chloride, potassium, and magnesium [1]. At present, liquid mine exploiting is the main exploitation form for the Qarhan Salt Lake. Salt mining ships with mining equipments are widely used to exploit carnallite which is located at the bottom of pools. Conventionally, workmen utilize rude ferric sampler to collect carnallite samples and estimate their thickness, providing guidance to the salt mining ship [2]. However, the turbid brine and uneven carnallite reduce the efficiency of exploitation, which could no longer meet the rapid mining requirements. | Zhibin XUE Jincun LIU Zhengxing WU Sheng DU Shihan KONG Junzhi YU | 2019 | Science China(Information Sciences)2019，62，8： | 8 |
| 5 | Porous surfur-doped hard carbon for excellent potassium storage显示文摘Hard carbon is promising anode for potassium-ion batteries(PIBs),however,the poor rate capability hinders its development as potential anode.To address this question,we design a sulfur-doped porous hard carbon(S-HC)for PIBs through the combination of structural design and composition adjustment.The as-designed S-HC exhibits a long cycling life with^191 mAh/g after 300 cycles at 1 A/g,and an excellent rate capability with^100 mAh/g at 5 A/g,which was attributed to its structural characteristics and compositions.The S-HC demonstrates to be promising anode in the future. | Xuan Xie Shihan Qi Daxiong Wu Huaping Wang Fang Li Xiaoxin Peng Jinfeng Cai Jiaojiao Liang Jianmin Ma | 2020 | Chinese Chemical Letters2020，31，1： | 4 |
| 6 | Effect of roughness and wettability of silicon wafer in cavitation erosion显示文摘Material damage of silicon wafer with different roughness and wettability was investigated by using the self-made vibration cavitation apparatus in de-ionized water. Various roughness and wettability of sili- con wafer were achieved by changing their morphology and depositing Au, diamond-like carbon films (DLC films) on them. Surface morphology was observed with a scanning electron microscope (SEM) and a surface profilometer, and wettability was characterized by the contact angle measurement. The cavitation erosion results showed that many tiny pits and cracks appeared on the wafer surface as a result of brittle fractures; the number and size of the pits and cracks increased with experiment time, which made material flake away finally; cavitation occurred more easily on the silicon wafer surface with the augment of roughness or contact angle by changing surface morphology or depositing Au, DLC thin film on it, which consequently aggravated cavitation damage. | JIANG NaNa LIU ShiHan CHEN DaRong | 2008 | Chinese Science Bulletin2008，53，18： | 4 |
| 7 | Ultralow-loss compact silicon photonic waveguide spirals and delay lines显示文摘Low-loss and compact optical waveguides are key for realizing various photonic integrated circuits with long onchip delay lines,such as tunable optical delay lines,optical coherence tomography,and optical gyroscopes.In this paper,a low-loss and compact silicon photonic waveguide spiral is proposed by introducing broadened Archimedean spiral waveguides with a tapered Euler S-bend.A 100-cm-long waveguide spiral is realized with a minimal bending radius as small as 10 μm by using a standard 220-nm-thick silicon-on-insulator foundry process,and the measured propagation loss is as low as 0.28 dB/cm.Furthermore,the present waveguide spirals are used to realize a 10-bit tunable optical delay line,which has a footprint as small as 2.2 mm × 5.9 mm and a dynamic range of 5120 ps with a fine resolution of 10 ps. | SHIHAN HONG LONG ZHANG YI WANG MING ZHANG YIWEI XIE DAOXIN DAI | 2022 | Photonics Research2022，10，1： | 3 |
| 8 | Affected zone generated around the erosion pit on carbon steel surface at the incipient stage of vibration cavitation显示文摘The characteristics of erosion pits on a carbon steel surface were investigated at the incipient stage of cavitation erosion. After a 5-minute experiment performed in an ultrasonic vibration system, needle-like erosion pits appeared on the polished steel surface, and a specially affected zone was formed around the pit. The shape of the pit and the plastic deformation of the affected zone indicate that the me- chanical impaction on the surface is the main reason for the cavitation damage. On the other hand, the iridescent color, the decreased surface hardness and the precipitated carbides on the affected zone prove that the affected zone has experienced a tempering process with the temperature higher than 300°C. The lack of oxygen in the affected zone also proves that it is not a chemical oxygen result. A special phenomenon that a carbon ring forms in the affected zone is explained as a result of the toroidal bubbles' heating effect at the final stage of the bubble collapse. | CHEN HaoShenh LI Jiang LIU ShiHan CHEN DaRong WANG JiaDao | 2008 | Chinese Science Bulletin2008，53，6： | 3 |
| 9 | Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system显示文摘Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate(4-OI) is a cell-permeable itaconate derivative and has been recognized as a promising therapeutic target for the treatment of inflammatory diseases. Here, we explored, for the first time,the protective effect of 4-OI on inhibiting periodontal destruction, ameliorating local inflammation, and the underlying mechanism in periodontitis. Here we showed that 4-OI treatment ameliorates inflammation induced by lipopolysaccharide in the periodontal microenvironment. 4-OI can also significantly alleviate inflammation and alveolar bone loss via Nrf2 activation as observed on samples from experimental periodontitis in the C57BL/6 mice. This was further confirmed as silencing Nrf2 blocked the antioxidant effect of 4-OI by downregulating the expression of downstream antioxidant enzymes. Additionally, molecular docking simulation indicated the possible mechanism under Nrf2 activation. Also, in Nrf2-/-mice, 4-OI treatment did not protect against alveolar bone dysfunction due to induced periodontitis, which underlined the importance of the Nrf2 in 4-OI mediated periodontitis treatment.Our results indicated that 4-OI attenuates inflammation and oxidative stress via disassociation of KEAP1-Nrf2 and activation of Nrf2 signaling cascade. Taken together, local administration of 4-OI offers clinical potential to inhibit periodontal destruction,ameliorate local inflammation for more predictable periodontitis. | Liangjing Xin Fuyuan Zhou Chuangwei Zhang Wenjie Zhong Shihan Xu Xuan Jing Dong Wang Si Wang Tao Chen Jinlin Song | 2022 | International Journal of Oral Science2022，14，3： | 3 |
| 10 | 2020 roadmap on two-dimensional materials for energy storage and conversion显示文摘Energy storage and conversion have attained significant intere st owing to its important applications that reduce CO2 emission through employing green energy.Some promising technologies are included metalair batteries,metal-sulfur batteries,metal-ion batteries,electrochemical capacitors,etc.Here,metal elements are involved with lithium,sodium,and magnesium.For these devices,electrode materials are of importance to obtain high performance.Two-dimensional(2 D) materials are a large kind of layered structured materials with promising future as energy storage materials,which include graphene,black phosporu s,MXenes,covalent organic frameworks(COFs),2 D oxides,2 D chalcogenides,and others.Great progress has been achieved to go ahead for 2 D materials in energy storage and conversion.More researchers will join in this research field.Under the background,it has motivated us to contribute with a roadmap on ’two-dimensional materials for energy storage and conversion. | Baolin Xu Shihan Qi Mengmeng Jin Xiaoyi Cai Linfei Lai Zhouting Sun Xiaogang Han Zifeng Lin Hui Shao Peng Peng Zhonghua Xiang Johan E.ten Elshof Rou Tan Chen Liu Zhaoxi Zhang Xiaochuan Duan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 11 | Damage to aircraft composite structures caused by directed energy system: A literature review显示文摘This paper presents a comprehensive review of the research studies on direct energy system effect on aircraft composite structures to develop a good understanding of state-of-the-art research and development in this area.The review begins with the application of composite materials in the aircraft structures and highlights their particular areas of application and limitations.An overview of directed energy system is given.Some of the commonly used systems in this category are discussed and the working principles of laser energy systems are described.The experimental and numerical studies reported regarding the aircraft composite structures subject to the effect of directed energy systems,especially the laser systems are reviewed in detail.In particularly,the general effects of laser systems and the relevant damage mechanisms against the composite structures are reported.The review draws attention to the recent research and findings in this field and is expected to guide engineers/researchers in future theoretical,numerical,and experimental studies. | Y.X.Zhang Zhi Zhu Richardson Joseph Isfakul Jamal Shihan | 2021 | Defence Technology(防务技术)2021，17，4： | 2 |
| 12 | Structurally tunable characteristics of ionic liquids for optimizing lithium plating/stripping via electrolyte engineering显示文摘Electrolyte chemistry offers the opportunity to regulate the solid electrolyte interphase(SEI) and Li^(+)solvation,which is considered to be crucial to the growth of lithium crystals for safe lithium metal batteries(LMBs).Structurally tunable characteristics of ionic liquids(ILs) from anion type,cationic substituent chain length and cationic substituents,will contribute this field.Here,we explore the influence mechanism of imidazole-based ILs as electrolyte additives on Li+solvation and the formation of SEI.ILs can participate into the formation of efficient SEI,together with cathode electrolyte interphase(CEI).Moreover,ILs can also regulate the sheath structure of Li^(+)solvation,to fasten the kinetics of Li.Furthermore,the imidazole-based cations with long alkyl chain can form an electrostatic shield around newly formed Li nucleus,and suppress further Li plating at this site.Under the optimized condition,the 1-octyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide([OMIm]TFSI) additive shows the best ability to enhance the electrochemical performance,endowing the Li||Li symmetric cell with a stable life(over800 h) at 0.5 mA cm^(-2) and the Li||LiNi_(0.6)Mn_(0.2)Co_(0.2)O_(2)(NMC622) full cell with a high capacity of 141.7 mAh g^(-1) after 200 cycles at 0.5 C. | Shihan Qi Jiandong Liu Jian He Huaping Wang Mingguang Wu Daxiong Wu Junda Huang Fang Li Xin Li Yurong Ren Jianmin Ma | 2021 | Journal of Energy Chemistry2021，30，12： | 2 |
| 13 | Recent Advances of Metal-Organic Frameworks-based Nanozymes for Bio-applications显示文摘Artificial nanoenzymes with enzyme-like catalytic activity have gradually become an alternative to natural enzymes due to their low production cost,high stability,and good tolerance.In recent years,various enzyme mimics have emerged with the rapid development of nano-teclnology.Metal-organic frameworks(MOFs)are a novel class of porous inorganic-organic hybrid materials made from metal ions/clusters and organic ligands,and MOFs-based nanozymes show great prospect in biosensing,biocatalysis,biomedical imaging,and therapeutic applications,due to unique properties,such as high specific surface area,high porosity,tunable morphology,and excellent biocatalytic properties.In this paper,the recent progresses concerning MOFs-based nanozymes are systematically summarized,including the synthesis,design strategies and related applications,which are divided into two major categories,namely,MOFs structured nanoenzymes and MOFs composite structured nanoenzymes.Meanwhile,the applications of various classifications of MOFs research are introduced.At the end,current challenges and future perspectives of MOFs-based nanozymes are also discussed.It is highly expected that this review on this important area can provide a meaningful guidance for tumor therapy,biosensing and other aspects. | WANG Yuda ZULPYA Mahmut ZHANG Xinyao XU Shihan SUN Jiao DONG Biao | 2022 | Chemical Research in Chinese Universities2022，38，6： | 2 |
| 14 | Pseudo-concentrated electrolytes for lithium metal batteries显示文摘Lithium metal batteries suffer from short lifespans and low Coulombic efficiency (CE) due to the high reactivity of Li and the poor stability of the solid electrolyte interphase (SEI). Herein, we propose the concept of a pseudo-concentrated electrolyte (PCE) induced by an electron-deficient additive (4-pyridylboronic acid;4-PBA) to form a robust, LiF-rich SEI, thus addressing the above issues. Molecular dynamics simulations confirm that 4-PBA can increase the coordination number of PF6^(-) anions in the Li+ solvation sheath to achieve pseudo-concentrated LiPF6 in the electrolyte. Moreover, the 4-PBA can scavenge harmful PF5 decomposed from LiPF6 to stabilize the LiF-rich SEI. The resulting robust LiF-rich SEI promotes Li growth along the SEI/Li interface and represses the growth of Li dendrites. Thus, excellent performance is achieved, with a high CE of 97.1% for a Li||Cu cell at 1.0 mA cm^(−2), and over 950 cycles at 0.5 mA cm^(−2) for Li||Li symmetric cells with 1.0 wt% 4-PBA electrolyte. Meanwhile, the resulting stable boron-containing cathode electrolyte interphase enables Li||LiNi0·6Co0·2Mn0·2O_(2) (NCM622) cells to achieve excellent stability, with a capacity retention of 86.9% after 200 cycles. | Huaping Wang Jiandong Liu Jian He Shihan Qi Mingguang Wu Fang Li Junda Huang Yun Huang Jianmin Ma | 2022 | eScience2022，2，5： | 2 |
| 15 | A Structural Approach to Synthesizing Soft Switching PWM Converters显示文摘 | WU Tsaifu LIANG Shihan CHEN Yukai | 2003 | IEEE Transactions on Power Electronics2003，18，1： | 1 |
| 16 | Ontology- based enterprise knowledge integration 显示文摘 | Huang Ning Diao ShiHan | 2008 | Robotics and Computer - Integrated Manufacturing2008，24，4： | 1 |
| 17 | Ontology-based enterprise knowledge integration显示文摘 | Huang Ning Diao Shihan | 2008 | Robotics and Computer-integrated Manufacturing2008，24，4： | 1 |
| 18 | Fuzzy Controller Designed by GA for Two-wheeled Mobile Robots 显示文摘 | WONG Chingehang WANG Hoiyi LI Shihan | 2007 | International Journal of Fuzzy Systems2007，9，1： | 1 |
| 19 | Self-assembled three-dimensional graphene/Fe3O4hydrogel for efficient pollutant adsorption and electromagnetic wave absorption显示文摘 | Yang Yue Zhao Yanrong Sun Shihan | 2016 | Materials Research Bulletin2016，73，1： | 1 |
| 20 | Polyetheramide Templated Synthesis of Monodisperse Mn_3O_4 Nanoparticles with Controlled Size and Study of the Electrochemical Properties显示文摘Monodisperse Mn3O4 nanoparticles were prepared solvothermally starting from manganese acetate by using polyether amide block copolymers(Pebax2533) as a template in isopropanol. The diameter of the nanoparticles in the range of 8.7 nm^31.5 nm was decreased with increase of Pebax2533 concentration.The electrochemical properties and application in supercapacitor of Mn3O4 nanoparticles were further studied.The results showed that smaller nanoparticles had a larger capacitance. The higher capacitance of 217.5 F/g at a current density of 0.5 A/g was obtained on 8.7 nm Mn3O4 nanoparticles. The specific capacitance retention of 82% was maintained after 500 times of continuous charge-discharge cycles. | Lin He Geng Zhang Yuanzhu Dong Zhenwei Zhang Shihan Xue Xingmao Jiang | 2014 | Nano-Micro Letters2014，6，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员