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| 1 | Bartter and Gitelman syndromes:Spectrum of clinical manifestations caused by different mutations显示文摘Bartter and Gitelman syndromes(BS and GS) are inherited disorders resulting in defects in renal tubularhandling of sodium,potassium and chloride.Previously considered as genotypic and phenotypic heterogeneous diseases,recent evidence suggests that they constitute a spectrum of disease caused by different genetic mutations with the molecular defects of chloride reabsorption originating at different sites of the nephron in each condition.Although they share some characteristic metabolic abnormalities such as hypokalemia,metabolic alkalosis,hyperplasia of the juxtaglomerular apparatus with hyperreninemia,hyperaldosteronism,the clinical and laboratory manifestations may not always allow distinction between them.Diuretics tests,measuring the changes in urinary fractional excretion of chloride from baseline after administration of either hydrochlorothiazide or furosemide show very little change(< 2.3%) in the fractional excretion of chloride from baseline in GS when compared with BS,except when BS is associated with KCNJ1 mutations where a good response to both diuretics exists.The diuretic test is not recommended for infants or young children with suspected BS because of a higher risk of volume depletion in such children.Clinical symptoms and biochemical markers of GS and classic form of BS(type III) may overlap and thus genetic analysis may specify the real cause of symptoms.However,although genetic analysis is available,its use remains limited because of limited availability,large gene dimensions,lack of hot-spot mutations,heavy workup time and costs involved.Furthermore,considerable overlap exists between the different genotypes and phenotypes.Although BS and GS usually have distinct presentations and are associated with specific gene mutations,there remains considerable overlap between their phenotypes and genotypes.Thus,they are better described as a spectrum of clinical manifestations caused by different gene mutations. | Amar Al Shibli Hassib Narchi | 2015 | World Journal of Methodology2015，5，2： | 25 |
| 2 | Impact of osteoporosis in dental implants:A systematic review显示文摘AIM: To assess the failure and bone-to-implant contact rate of dental implants placed on osteoporotic subjects. METHODS: Extensive examination strategies were created to classify studies for this systematic review. MEDLINE(via Pub Med) and EMBASE database were examined for studies in English up to and including May 2014. The examination presented a combination of the MeS H words described as follow: 'osteoporosis' or 'osteopenia' or 'estrogen deficiency' AND 'implant' or 'dental implant' or 'osseointegration'. Assessment of clinical and/or histological peri-implant conditions in osteoporosis subjects treated with titanium dental implants. The examination included a combination of the MeS H terms described as follow: 'osteoporosis' or 'osteopenia' or 'estrogen deficiency' AND 'implant' or 'dental implant' or 'osseointegration'.RESULTS: Of 943 potentially eligible articles, 12 were included in the study. A total of 133 subjects with osteoporosis, 73 subjects diagnosed with osteopenia and 708 healthy subjects were assessed in this systematic review. In these subjects were installed 367, 205, 2981 dental implants in osteoporotic, osteopenic and healthy subjects, respectively. The failure rate of dental implant was 10.9% in osteoporotic subjects, 8.29% in osteopenic and 11.43% in healthy ones. Bone-to-implant contact obtained from retrieved implants ranged between 49.96% to 47.84%, for osteoporosis and non-osteoporotic subjects. CONCLUSION: Osteoporotic subjects presented higher rates of implant loss, however, there is a lower evidence to strengthen or refute the hypothesis that osteoporosis may have detrimental effects on bone healing. Consequently, final conclusions regarding the effect of osteoporosis in dental implant therapy cannot be made at this time. There are no randomized clinical trial accessible for evaluation and the retrospectivenature of the evaluated studies shall be taken in account when interpreting this study. | Gabriela Giro Leandro Chambrone Abrao Goldstein Jose Augusto Rodrigues Elton Zenóbio Magda Feres Luciene Cristina Figueiredo Alessandra Cassoni Jamil Awad Shibli | 2015 | World Journal of Orthopedics2015，6，2： | 11 |
| 3 | Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon α 2a therapy for chronic hepatitis C virus infection显示文摘The combination of pegylated interferon (Peg-IFN) and ribavirin is the standard of care for chronic hepatitis C virus (HCV) infection treatment. In general, common side effects related to this combination therapy are mild and are very well tolerated. However, peripheral neuropathy including demyelinating polyneuropathy related to Peg-IFN is extremely rare. We present the first case of an acute inflammatory demyelinating polyneuropathy (AIDP) associated with Peg-IFN-α 2a (Pegasys) after 16 wk of a combination therapy with Pegasys and ribavirin in a 65-year-old woman with chronic HCV infection. She developed tingling, numbness, and weakness of her upper and lower extremities and was hospitalized for acute neurological deficits. Her clinical course, neurological findings, an electromyogram (EMG), nerve conductions studies (NCS), muscle biopsy, and a sural nerve biopsy were all consistent with AIDP likely related to Pegasys use. The patient recovered completely with the use of intravenous immunoglobulin (IVIG) including physical therapy and neurological rehabilitation. It is very important that gastroenterologists and/or hepatologists recognize this rare neurological complication related to Peg-IFN treatment very early, since it requires a prompt discontinuation of therapy including an immediate referral to a neurologist for the confirmation of diagnosis, management, and the prevention of long-term neurological deficits. | Vijay Khiani Thomas Kelly Adeel Shibli Donald Jensen Smruti R Mohanty | 2008 | World Journal of Gastroenterology2008，14，2： | 7 |
| 4 | Wilsons 疾病作为尖锐胰腺炎,胆管炎,和黄疸介绍的诊断挑战显示文摘 Wilson’s disease is a rare disorder of copper transport in hepatic cells,and may present as cholestatic liver disease;pancreatitis and cholangitis are rarely associated with Wilsons’s disease.Moreover,cases of Wilson s disease presenting as pigmented gallstone pancreatitis have not been reported in the literature.In the present report,we describe a case of a 37-year-old man who was admitted with jaundice and abdomina pain.The patient was diagnosed with acute pancreatitis,cholangitis,and obstructive jaundice caused by pigmented gallstones that were detected during retrograde cholangiopancreatography.However,because of his long-term jaundice and the presence of pigmented gallstones,the patient underwent further evaluation for Wilson’s disease,which was subsequently confirmed.This patient’s unique presentation exemplifies the overlap in the clinical and laboratory parameters of Wilson’s disease and cholestasis,and the difficulties associated with their differentiation.It suggests thatWilson’s disease should be considered in patients with pancreatitis,cholangitis,and severe protracted jaundice caused by pigmented gallstones. | Elchanan Nussinson Azmi Shahbari Fahmi Shibli Elena Chervinsky Philippe Trougouboff Arie Markel | 2013 | World Journal of Hepatology2013，5，11： | 5 |
| 5 | 石榴皮、籽、花中总黄酮的含量比较及体外抗氧化能力研究显示文摘目的提取石榴皮、籽、花中的总黄酮并进行体外抗氧化能力的比较测定。方法以70%乙醇提取石榴皮、籽、花中总黄酮,采用直接显色法测定三者中总黄酮含量并测定石榴总黄酮对1,1-二苯基-2-三硝基苯肼(DPPH)自由基的清除能力、还原能力以及对羟自由基的抑制能力。结果1g石榴花中总黄酮含量为112.13mg,1g石榴皮中总黄酮含量为121.16mg,由于石榴籽与芦丁没有吻合的峰,故无法测量石榴籽中的黄酮含量。体外抗氧化实验中DPPH清除50%时所需要的石榴皮总黄酮的浓度为0.010 8mg/mL,石榴花总黄酮的浓度为0.015 1mg/mL。还原能力测定实验中,石榴皮总黄酮最大吸光度1.748,而同浓度维生素C仅为1.169;石榴花总黄酮最大吸光度1.732,维生素C为0.830;石榴皮总黄酮抑制能力对羟自由基抑制能力为355.7U/mL,同浓度维生素C溶液为273.2 U/mL,石榴花总黄酮为445.2 U/mL,同浓度维生素C溶液为239.1 U/mL。结论石榴皮中总黄酮含量>石榴花总黄酮含量。3个抗氧化试验结果显示石榴皮、石榴花总黄酮体外抗氧化能力为维生素C的2~3倍。 | 杨肖 陶威熔 孙秀超 古汉克孜.买买提 肖平稳 哈尼克孜.买买提依明 Syed Shibli Ahmed 杨凡 魏媛媛 | 2017 | 新疆医科大学学报2017，40，11： | 5 |
| 6 | 岩相骨架的地质统计模拟显示文摘储集层非均质性是碎屑岩储集层描述中的重要问题。与流体性质分布的不确定性相比,岩相骨架的不确定性对流体预测影响更大。近十年来,地质统计方法大量地应用于岩相骨架的模拟中,其模拟方法主要有离散及连续两类。用数学语言对4个主要的离散模拟方法(序贯指示模拟、截断高斯模拟、模拟退火及示性点过程模拟)进行概述,展示其工作过程,讨论各自的优缺点,特别强调如何合并次生数据以及在现场应用的可能性。此外,还提出了该领域未来的研究方向。 | 王留奇 P M Wong S Shibli 牛艳平 | 1999 | 石油勘探与开发1999，26，3： | 4 |
| 7 | Significance of platelet count in children admitted with bronchiolitis显示文摘AIM To determine the true prevalence of thrombocytosis in children less than 2 years of age with bronchiolitis,its association with risk factors,disease severity and thromboembolic complications.METHODS A retrospective observational medical chart review of 305 infants aged two years or less hospitalized for bronchiolitis.Clinical outcomes included disease severity,duration of hospital stay,admission to pediatric intensive care unit,or death.They also included complications of thrombocytosis,including thromboembolic complications such as cerebrovascular accident,acute coronary syndrome,deep venous thrombosis,pulmonary embolus,mesenteric thrombosis and arterial thrombosis and also hemorrhagic complications such as bleeding(spontaneous hemorrhage in the skin,mucous membranes,gastrointestinal,respiratory,or genitourinary tracts).RESULTS The median age was 4.7 mo and 179 were males(59%).Respiratory syncytial virus was isolated in 268(84%),adenovirus in 23(7%) and influenza virus A or B in 13(4%).Thrombocytosis(platelet count > 500 × 109/L) occurred in 88(29%;95%CI:24%-34%),more commonly in younger infants with the platelet count declining with age.There was no significant association with the duration of illness,temperature on admission,white blood cell count,serum C-reactive protein concentration,length of hospital stay or admission to the intensive care unit.No death,thrombotic or hemorrhagic events occurred.CONCLUSION Thrombocytosis is common in children under two years of age admitted with bronchiolitis.It is not associated with disease severity or thromboembolic complications. | Amar Al Shibli Najla Alkuwaiti May Hamie Dima Abukhater Muhammad B Noureddin Abdulla Amri Salwa Al Kaabi Aysha Al Kaabi Mariam Harbi Hassib Narchi | 2017 | World Journal of Clinical Pediatrics2017，6，2： | 3 |
| 8 | Cloud authorization: exploring techniques and approach towards effective access control framework显示文摘 | Rahat MASOOD Muhammad Awais SHIBLI Yumna GHAZI Ayesha KANWAL Arshad ALI | 2015 | Frontiers of Computer Science2015，9，2： | 3 |
| 9 | Leonurus sibiricus L.(honeyweed):A review of its phytochemistry and pharmacology显示文摘Leonurus sibiricus is a herbaceous plant found in many countries in Asia and America.This plant is widely practiced as a remedy for the treatment of diabetes,menstrual irregularities,and bronchitis.The approval of therapeutic implications of any drugs depends on the well characterized mode of actions of the compounds.The bioactive compounds like diterpenes,triterpenes,flavonoids and phenolic acids in Leonurus sibiricus show analgesic,anti-inflammatory,anti-oxidant,anti-atherogenic and antihemorrhagic,anti-diabetic,anti-bacterial and allelopathic potency.Interestingly,the expression level of some genes is altered by the crude extract treatments,which are effective against cancers,diabetes and cardiovascular diseases where the molecular mechanisms are yet to be explored.Intriguingly,the extracts significantly induce nitric oxide production by endothelial nitric oxide synthase,a signaling molecule of vasodilation in combination with interferon-y indicating positive effect on atherosclerosis.Further investigations are required to unlock the effects of bioactive compounds found in extracts at clinical settings. | Abu Sayed AshraM Alam Shariful Islam Taif Ali Emdad Ullah Abu Zaffar Shibly Aslam Ali Mahdi Hasan-Olive | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，12： | 2 |
| 10 | Combination of low vascular endothelial growth factor A (VEGF‐A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer显示文摘 | TomDonnem KhalidAl‐Shibli SigveAndersen SamerAl‐Saad Lill‐ToveBusund Roy M.Bremnes | 2010 | Cancer2010，，18： | 2 |
| 11 | Histological comparison be- tween implants retrieved from patients with and without osteoporo- sis显示文摘 | Shibli JA Aguiar KC Melo L | 2008 | Int J Oral Maxillofac Surg2008，37，4： | 1 |
| 12 | Prevalence of maxillary si- nus septa in 1024 subjects with edentulous upper jaws: a retrospec- tive study 显示文摘 | Shibli JA Faveri M Ferrari DS | 2007 | J Oral Implantol2007，33，5： | 1 |
| 13 | Osseous grafting part I:autografts and allografts for periodontal regeneration--a literature review显示文摘 | AlGhamdi AS Shibly O Ciancio SG | 2010 | J Int Acad Periodontol2010，12，2： | 1 |
| 14 | Development of TiO2-supported nano-RuO2-incorporated catalytic nickel coating for hydrogen evolution reaction 显示文摘 | Shibli S M A Dilimon V S | 2008 | International Journal of Hydrogen Energy2008，33，4： | 1 |
| 15 | ZrO2-reinforeed Ni - P plate: An effective catalytic surface for hydrogen evolution 显示文摘 | Shibli S M A Dilimon V S Deepthi T | 2006 | Appl Surf Sei2006，253，4： | 1 |
| 16 | Connective tissue graft to correct peri -implant soft tissue margin: A clinical report 显示文摘 | Shibli J A d' avila S Marcantonio E Jr | 2004 | J Prosthet Dent2004，91，2： | 1 |
| 17 | Efficacy of standard(SLA)and modified sandblasted and acid-etched(SLActive)dental implantsin promoting immediate and/or early occlusal loading protocols:a systematic review of prospective studies显示文摘 | Chambrone L Shibli J Mercúrio C | 2015 | Clin Oral Implants Res2015，26，： | 1 |
| 18 | An equivalent soil mechanics formulation for rigid wheels in deform- able terrain, with application to planetary exploration rovers显示文摘 | SHIBLY H IAGNEMMA K DUBOWSKY S | 2005 | Journal of Terramechanics2005，42，： | 1 |
| 19 | An equivalent soil mechanics formulation for rigid wheels in deformable terrain,with application to planetary exploration rovers显示文摘 | SHIBLY H IAGNEMMA K DUBOWSKY S | 2005 | Journal of Terramechanics2005，，42： | 1 |
| 20 | Activation of aluminium alloy sacrificial anodes by selenium显示文摘 | Shibli S M A Gireesh V S | 2005 | Corrosion Science2005，，47： | 1 |
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