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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Why we buy what we buy: A theory of consumption values 显示文摘 | Sheth J N Newman B I Gross B L | 1991 | Journal of business research1991，22，2： | 1 |
| 3 | Children with new-onset epilepsy: neuropsychological status and brain structure显示文摘 | Hermann B Jones J Sheth R | 2006 | Brain2006，129，： | 1 |
| 4 | Parietal occipital edemain hypert ensive encephalopathy:A Pathogenic mechanism显示文摘 | Sheth R D Riggs J E Bodenstenier J B | 1996 | Eur-Neurol1996，36，： | 1 |
| 5 | Why We Buy what We Buy: a Theory of Consumption Values显示文摘 | Sheth J N Newman B I Gross B L | 1991 | Journal of Business Re- search1991，，22： | 1 |
| 6 | ' Parapharyngeal space' tumors: a cytopathological study of 24 cases on fine-needle aspiration显示文摘 | OLIAI B R SHETH S BURROUGHS F H | 2005 | Diagn Cytopathol2005，32，： | 1 |
| 7 | Ankle disk t raining influences reaction times of selected muscles in a simulated ankle sprain显示文摘 | Sheth P Yu B Laskowski ER | 1997 | Am J Sports Med1997，25，： | 1 |
| 8 | Why we buy what we buy:A theory of consumption values 显示文摘 | Sheth J N Newman B I Gross B L | 1991 | Journal of Business Research1991，22，2： | 1 |
| 9 | Role of Chain Symmetry and Hydrogen Bonding in Segmen- ted Copolymers with Monodisperse Hard Segments 显示文摘 | SHETH J P KLINEDINST D B WILKES G L | 2005 | Polymer2005，46，18： | 1 |
| 10 | Trace elements affect methanogenic activity and diversity in enrichments from subsurface coalbed produced water显示文摘 | Unal B Perry VR Sheth M | 2012 | Frontiers in Microbiology2012，3，： | 1 |
| 11 | Development of a single ELISA fordetection of sulphonamides显示文摘 | Sheth H B Sporns P | 1991 | Journal of Agriculture and Food Chemistry1991，39，： | 1 |
| 12 | Inhibitory of P38 mitogen activated protein kinase increase lipopolysaccharide induced inhibition of apoptosis in neutrophils by activating extracellular signal-regulated kinase 显示文摘 | Sheth K Friel J Nolan B | 2001 | Surgey2001，130，2： | 1 |
| 13 | Why we buy what we buy: a theory of eonsumption values 显示文摘 | Sheth J N Newman B I and Gross' B L | 1991 | Journal of Business Research1991，22，3： | 1 |
| 14 | Experimental studies on producer gas generation from wood waste in a downdraft biomass gasifier显示文摘 | Sheth P N Babu B V | 2009 | Bioresource Technology2009，100，12： | 1 |
| 15 | Why We Buy What We Buy: Theory of Consumption Vaue 显示文摘 | SHETH J N NEWMAN B I GROSS B L | 1991 | Journal of Business Re- search1991，22，： | 1 |
| 16 | Modeling and simulation of reduction zone of downdraft biomass gasifier:Effect of char reactivity factor显示文摘 | BABU B V SHETH P N | 2006 | Energy Conversion and Management2006，47，1516： | 1 |
| 17 | Consumption values and market choices: Theory and applications 显示文摘 | Sheth J N Newman B I Gross L G | 1992 | Journal of Marketing Research1992，29，4： | 1 |
| 18 | A historical approach to continental flood basalt volcanism: insights into pre-volcanic rifting, sedimentation and early alkaline magmatism 显示文摘 | Sheth B C | 1999 | Earth and Planetary Science Letters1999，168，： | 1 |
| 19 | Role of chain symmetry and hydrogen bonding in aegmnented copolymers with monodisperse hard segments显示文摘 | Sheth J P Klinedinst D B Wilkes G L | 2005 | Polymer2005，46，： | 1 |
| 20 | Why we buy whatwe buy : a theory of consumption values 显示文摘 | SHETH J N NEWMAN B I GROSS B L | 1991 | Journal ofBusiness Research1991，22，2： | 1 |
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