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| 1 | Alcohol-induced protein hyperacetylation: Mechanisms and consequences显示文摘Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein hyperacetylation. This reversible, posttranslational modification on the ε-amino groups of lysine residues has been shown to modulate multiple, diverse cellular processes ranging from transcriptional activation to microtubule stability. Thus, alcoholinduced protein hyperacetylation likely leads to major physiological consequences that contribute to alcohol-induced hepatotoxicity. Lysine acetylation is controlled by the activities of two opposing enzymes, histone acetyltransferases and histone deacetylases. Currently, efforts are aimed at determining which enzymes are responsible for the increased acetylation of specifi c substrates. However, the greater challenge will be to determine the physiological ramifications of protein hyperacetylation and how they might contribute to the progression of liver disease. In this review, we will fi rst list and discuss the proteins known to be hyperacetylated in the presence of ethanol. We will then describe what is known about the mechanisms leading to increased protein acetylation and how hyperacetylation may perturb hepatic function. | Blythe D Shepard Pamela L Tuma | 2009 | World Journal of Gastroenterology2009，15，10： | 3 |
| 2 | Alcohol-induced alterations of the hepatocyte cytoskeleton显示文摘The hepatocyte cytoskeleton consists of three fi lamentous networks: microtubules, actin microfi laments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three fi lament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in protein expression levels and post-translational modifi cations. Finally, we will describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how they might contribute to the progression of liver disease. | Blythe D Shepard Pamela L Tuma | 2010 | World Journal of Gastroenterology2010，16，11： | 2 |
| 3 | Human disease modeling with induced pluripotent stem cells显示文摘 | Alan Trounson Kelly A Shepard Natalie D DeWitt | 2012 | Current Opinion in Genetics & Development2012，，5： | 2 |
| 4 | Fluid percussion baro- trauma chamber: a new in vitro model for traumatic brain injury 显示文摘 | Scott R Shepard M D Jamshid B G | 1991 | J Surgical R es1991，51，5： | 1 |
| 5 | Mortality of adult brown planthopper (BPH) in different types of cages used for bioassays of entomogenic fungi显示文摘 | Aguda R Rombach M C Shepard B M Roberts D W | 1985 | International Rice Research Newsletter1985，10，： | 1 |
| 6 | Straight talk on anti- spoofing显示文摘 | Wesson K Shepard D Humphreys T | 2012 | GPS World2012，23，1： | 1 |
| 7 | Users drive research into new growth regu- lator applications显示文摘 | Shepard D | 2002 | Turfgrass Trends2002，11，4： | 1 |
| 8 | Nearshore water circulation related to bottom topography and wave refraction显示文摘 | Shepard F P Inman D L | 1950 | Transactions American Geophysical U- nion1950，31，： | 1 |
| 9 | Two-componet regulator o~ Enterococcus faecalis eyltolysin responds to quorum-sening autoinduction 显示文摘 | Haas W Shepard B D Gilmore M S | 2003 | Nature2003，415，： | 1 |
| 10 | Impact of recycling filter backwash water on organic removal in coagulation - sedimentation processes 显示文摘 | Gottfried A Shepard A D Hardiman K | 2008 | Water Res2008，42，18： | 1 |
| 11 | Alkaline Reactions of Some Simple Quinone Methide- Anthrahydroquinone Adducts显示文摘 | Dimmel D R Shepard D | 1982 | Journal of Wood Chemistry and Technology1982，2，1： | 1 |
| 12 | Impact of recycling filter backwash water on organic removal in coagulation-sedimentation processes显示文摘 | Gotffried A Shepard A D Hardiman K | | 0，，18： | 1 |
| 13 | Energy equivalent pressure 显示文摘 | SHEPARD R B SIMPSON D C SHARP J F | 1966 | Arch Surg1966，93，5： | 1 |
| 14 | Legionnaires' disease, isolation of a bacterium and demonstration of its role in other respiration diseases 显示文摘 | McDade J E Shepard C C Fraser D W | 1977 | N Engl J Med1977，297，22： | 1 |
| 15 | Antibiotic-resistant enterococci : the mechanisms and dynamics of drug introduction and resistance显示文摘 | SHEPARD B D GILMORE M S | 2002 | Microbes and Infection2002，4，： | 1 |
| 16 | Survival Versus Consumption 显示文摘 | Shepard D S Zeckhauser R J | 1984 | Manage Science1984，30，4： | 1 |
| 17 | Impact of recycling filter backwash water on organic removal in coagulation-sedimentation processes显示文摘 | Gottfried A Shepard A D Hardiman K | 2008 | Water Research2008，42，18： | 1 |
| 18 | Adult-onset he- reditary ataxia in Scotland 显示文摘 | Koeppen A H Hans M B Shepard D 1 | 1977 | Arch Neurol1977，34，10： | 1 |
| 19 | Straight talk on anti-spoofing: securing the future of PNT显示文摘 | Wesson K Shepard D Humphreys T | 2012 | GPS World2012，，： | 1 |
| 20 | Metals in water-Determining natural background concentrations in mineralized areas显示文摘 | Shepard T A Angina E E | 1992 | Environmental Science and Technology1992，26，： | 1 |
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