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1篇 您的检索式：作者名="Shenjun HU"

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		题名	作者	年代	出处	被引量
	1	Downregulation effects of beta-elemene on the levels of plasma endotoxin,serum TNF-alpha,and hepatic CD14 expression in rats with liver fibrosis显示文摘It has been demonstrated thatβ-elemene could protect against carbon tetrachloride(CCl_(4))-induced liver fibrosis in our laboratory work,and the aim of this paper is to reveal the protective mechanisms ofβ-elemene.The hepatic fibrosis experimental model was induced by the hypodermical injection of CCl_(4) in Wistar male rats.β-elemene was intraperitoneally administered into rats for 8 weeks(0.1 mL/100 g bodyweight per day),and plasma endotoxin content was assayed by biochemistry.The serum TNF-αlevel was detected using radioactive immunity.CD14 expression in rat livers was measured by immunohistochemistry and Western blot.The results showed thatβ-elemene can downregulate the levels of plasma endotoxins,serum TNF-α,and hepatic CD14 expression in rats with liver fibrosis.β-elemene plays an important role in downregulating the lipopolysaccharide signal transduction pathway,a significant pathway in hepatic fibrosis development.	Jianguo LIU Zhe ZHANG Jiechang GAO Jiwen XIE Lin YANG Shenjun HU	2011	Frontiers of Medicine2011，5，1：	1

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