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| 1 | Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery显示文摘Nerve guidance conduits with hollow lumen fail to regenerate critical-sized peripheral nerve defects(15 mm in rats and 25 mm in humans),which can be improved by a beneficial intraluminal microenvironment.However,individual cues provided by intraluminal filling materials are inadequate to eliminate the functional gap between regenerated nerves and normal nerves.Herein,an aligned fibrin/functionalized self-assembling peptide(AFG/fSAP)interpenetrating nanofiber hydrogel that exerting synergistic topographical and biochemical cues for peripheral nerve regeneration is constructed via electrospinning and molecular self-assembly.The hydrogel possesses an aligned structure,high water content,appropriate mechanical properties and suitable biodegradation capabilities for nerve repair,which enhances the alignment and neurotrophin secretion of primary Schwann cells(SCs)in vitro,and successfully bridges a 15-mm sciatic nerve gap in rats in vivo.The rats transplanted with the AFG/fSAP hydrogel exhibit satisfactory morphological and functional recovery in myelinated nerve fibers and innervated muscles.The motor function recovery facilitated by the AFG/fSAP hydrogel is comparable with that of autografts.Moreover,the AFG/fSAP hydrogel upregulates the regeneration-associated gene expression and activates the PI3K/Akt and MAPK signaling pathways in the regenerated nerve.Altogether,the AFG/fSAP hydrogel represents a promising approach for peripheral nerve repair through an integration of structural guidance and biochemical stimulation. | Shuhui Yang Jinjin Zhu Changfeng Lu Yi Chai Zheng Cao Jiaju Lu Zhe Zhang He Zhao Yin-Yuan Huang Shenglian Yao Xiangdong Kong Peixun Zhang Xiumei Wang | 2022 | Bioactive Materials2022，7，2： | 3 |
| 2 | Copula entropy and its application in hydrological correlation analysis 显示文摘 | CHEN Lu GUO Shenglian | 2013 | Journal of Water Resources Research2013，2，2： | 1 |
| 3 | Venation Skeleton- baSed Modeling Plant Leaf Wilting显示文摘 | Lu Shenglian Zhao Chunjiang Guo Xinyu | 2009 | International Journal of Computer Games Technology2009，，： | 1 |
| 4 | Venation Skeleton-based Modeling Plant Leaf Wilting显示文摘 | Lu Shenglian Zhao Chunjiang Guo Xinyu | 2009 | International Journal of Computer Games Technology2009，，2009： | 1 |
| 5 | Venation skeleton-based modeling plant leaf wilting 显示文摘 | LU Shenglian ZHAO Chunjiang GUO Xinyu | 2009 | International Journal of Computer Games Technology2009，18，： | 1 |
| 6 | Influence of temperature and light gradient on leaf arrangement and geometry in cucumber canopies: Structural phenotyping analysis and modelling显示文摘Accurate structural phenotyping analysis is essential to understand plant architectural adaptation strategy to environment change.The aim of this study was to analyze leaf arrangement and geometry influenced by azimuthally generated light gradient;and to simulate static and heterogeneous cucumber canopies using regression equations by considering more geometric parameters.Three continuous measurements of structural organ parameters were obtained to fit the organ initiation and expansion curves.Four measurements with three density treatments were obtained to validate model accuracy.To describe leaf distribution and orientation characteristics in more detail,azimuth and elevation models were introduced into canopy structure modelling.Leaf distribution frequency was simulated based on leaf area index and solar elevation angle while leaf elevation was simulated based on leaf azimuth and acropetal phytomer number.This study provides an important basis for structural phenotyping analysis of cucumber canopy,which is essential for more accurate functional-structural modelling in the future. | Tingting Qian Xiuguo Zheng Xinyu Guo Weiliang Wen Juan Yang Shenglian Lu | 2019 | Information Processing in Agriculture2019，6，2： | 0 |
| 7 | A novel method for extracting skeleton of fruit treefrom 3D point clouds显示文摘Tree skeleton could be useful to agronomy researchers because the skeleton describes the shape and topological structure of a tree.The phenomenon of organs’mutual occlusion in fruit tree canopy is usually very serious,this should result in a large amount of data missing in directed laser scanning 3D point clouds from a fruit tree.However,traditional approaches can be ineffective and problematic in extracting the tree skeleton correctly when the tree point clouds contain occlusions and missing points.To overcome this limitation,we present a method for accurate and fast extracting the skeleton of fruit tree from laser scanner measured 3D point clouds.The proposed method selects the start point and endpoint of a branch from the point clouds by user’s manual interaction,then a backward searching is used to find a path from the 3D point cloud with a radius parameter as a restriction.The experimental results in several kinds of fruit trees demonstrate that our method can extract the skeleton of a leafy fruit tree with highly accuracy. | Shenglian Lu Guo Li Jian Wang | 2020 | International Journal of Modeling, Simulation, and Scientific Computing2020，11，6： | 0 |
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