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| 1 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 2 | Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population显示文摘 | Xu RY Ye P Luo LM Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 3 | Development and evaluation of an efficient HPLC/MS/MS method for the simultaneous determination of pseudoephedrine and cetirzine in human plasma:Plasma:application to phase-1 pharmacolinetic study显示文摘 | Ma M Feng F Sheng Y | 2007 | Cromatogr B Analyt Technol Biomed Life Sci2007，846，12： | 1 |
| 4 | Seasonal variation of solvent extractable organic compounds in the aerosols in Qingdao, China显示文摘 | Guo Z G Sheng L F Feng J L | 2003 | Atmospheric Environment2003，37，13： | 1 |
| 5 | A numerical simulation of gas flow during coaL/gas outbursts 显示文摘 | Otuonye F Sheng J | 1994 | Geotechnical and Geological Engineering1994，12，： | 1 |
| 6 | Investigation of PEG adsorption on the surface of zinc oxide nanoparticles 显示文摘 | Liu F Sheng C Han N X | 2004 | Power Technology2004，145，1： | 1 |
| 7 | Mechanism of the B3 to B1 transformation in cubic A1N under uniaxial stress 显示文摘 | ZHANG R F SHENG S H VEPREK S | 2007 | Phys Rev B2007，76，7： | 1 |
| 8 | Seasonal variation of solvent extractable organic compounds in the aerosols in Qingdao, China显示文摘 | Guo Z G Sheng L F Feng J L | 2003 | Atmospheric Environment2003，37，13： | 1 |
| 9 | Microstructureevolution and mechanical properties of Ni3AI/A1203 composite during self-propagation high-temperature synthesis and hot extrusion显示文摘 | SHENG L Y YANG F XI T F | 2012 | Materials Science En- gineering : A2012，555，： | 1 |
| 10 | Surface modification of acrylonitrile copolymer members by grafting acrylamide:initiation by ceric ions显示文摘 | Yuan X Y Sheng J He F | | 0，，08： | 1 |
| 11 | Novel xylanase from a holstein cattle rumen metagenomic library and its application in xylooligosaccharide and ferulic acid production from wheat straw显示文摘 | Cheng F Sheng J Dong R | 2012 | Journal of Agricultural and Food Chemistry2012，60，12： | 1 |
| 12 | Simultaneousestimation of the profiles of the temperature and thescattering albedo in an absorbing,emitting,andisotropically scattering medium by inverse analysis显示文摘 | Zhou H C Yuan P Sheng F | 2000 | International Journal of Heat and Mass Transfer2000，43，23： | 1 |
| 13 | Increased cadmium and lead uptake of a cadmium hyperaccumulator tomato by cadmium-resistant bacteria 显示文摘 | HE L Y CHEN A J REN G D ZHANG Y F QIAN M SHENG X F | 2009 | Ecotoxicology and Environmental Safety2009，72，： | 1 |
| 14 | Oxy-fuel combustion technology for coal-fired power generation显示文摘 | BUHRE B J P ELLIOTT L K SHENG C D GUPTA R P WALL T F | 2005 | Prog Energy Combust2005，31，4： | 1 |
| 15 | Kruppel -like factor 2 protects a- gainst ischemic stroke by regulating endothelial blood brain barrier function 显示文摘 | Shi H Sheng B Zhang F | 2013 | Am J Physiol Heart Circ Physiol2013，304，6： | 1 |
| 16 | Molecular evolution and functional specialization of chalcone synthase superfamily from Phalaenopsis orchid显示文摘 | Han Y Y Ming F Wang W Wang J W Ye M M Sheng D L | 2006 | Genetica2006，128，123： | 1 |
| 17 | Identification and characterization of the miRNA transcriptome of ovis aries 显示文摘 | Zhang S F Zhao F P Wei C H Sheng X H Ren H X Xu L Y l u J Liu J S Zhang L Du L X | 2013 | PLoS One2013，8，58： | 1 |
| 18 | BRAFV600E mutation in papillary thyroid microcarcinoma:a meta-analysis显示文摘 | Li F Chen G Sheng C | 2015 | En- docr Relat Cancer2015，22，2： | 1 |
| 19 | Sin显示文摘 | Yan X Z Kuang X Y Mao A J Kuang F G Wang Z H Sheng X W 2013 Acta Phys | 2013 | 62 107402 (in Chinese)2013，，： | 1 |
| 20 | an Attempt for the Stabilization of Supported Liquid Membrane 显示文摘 | Masaaki T Yasusi S Sheng S F | 2000 | Separation and Purification Technology2000，21，： | 1 |
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